Patents by Inventor Jeffrey Seitzinger
Jeffrey Seitzinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070267768Abstract: The present invention provides a method of producing porous structures, particles or matrixes, which may be comprised of one or a plurality of components, an apparatus for carrying out the method and particles formed in accordance with the method. The method is particularly suitable for producing porous composite or pure particles for pharmaceutical applications. In accordance with the method, a composite comprising a material such as a pharmaceutical, a biodegradable polymers and/or a biological agent is formed. The composite must further comprise a material that is soluble in supercritical fluid. Extraction of the supercritical fluid soluble material produces porous structures, which may be in the form of particles or matrixes.Type: ApplicationFiled: June 21, 2005Publication date: November 22, 2007Inventors: Pratibhash Chattopadhyay, Boris Shekunov, Jeffrey Seitzinger
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Publication number: 20070158266Abstract: An apparatus and method for producing particles using supercritical fluid with enhanced mixing. The process includes a vessel having an inner surface defining a chamber. A high-speed shear or turbulent mixer is incorporated inside the vessel in order to create a region of enhanced mixing (mixing zone). A supercritical fluid pump communicates with the first inlet, and supplies supercritical fluid into the mixing zone through the first inlet. A solution pump communicates with the second inlet, and supplies solution into the mixing zone through the second inlet. A mixer assembly includes a motor drive and a rotor. The rotor is in the mixing zone and can mix the solution and the supercritical fluid. Particles are produced when the solution and the supercritical fluid are pumped into the mixing zone while the rotor is mixing. The design of the mixer and the direction of the flow of materials into the chamber creates a plug flow in the mixing zone.Type: ApplicationFiled: March 16, 2007Publication date: July 12, 2007Applicant: FERRO CORPORATIONInventors: Boris Shekunov, Pratibhash Chattopadhyay, Jeffrey Seitzinger
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Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions
Publication number: 20060153921Abstract: The present invention provides a method of producing particles from solution-in-supercritical fluid or compressed gas emulsions. In accordance with the method of the invention, a solution that includes a solute dissolved in a solvent is contacted with supercritical fluid or compressed gas to form a solution-in-super critical fluid or compressed gas emulsion. The emulsion is sprayed through an orifice to create spray droplets. The supercritical fluid or compressed gas and the solvent are removed from the spray droplets resulting in the formation of particles that include the solute. In one embodiment of the invention, the solvent is removed from the spray droplets by lyophilization. In another embodiment of the invention, the solvent is removed from the spray droplets by evaporation.Type: ApplicationFiled: June 2, 2004Publication date: July 13, 2006Applicant: Ferro CorporationInventors: Pratibhash Chattopadhyay, Boris Shekunov, Jeffrey Seitzinger -
Publication number: 20060145375Abstract: The present invention provides an apparatus and methods of producing particles that include a polymer, a wax and/or lipid and, optionally, a biologically active substance. In accordance with the methods of the invention, a load stock including a polymer, a wax and/or a lipid that is a solid at standard temperature and pressure and, optionally, a biologically active substance is provided. The load stock is contacted with a supercritical fluid to form a melt. The melt is contacted with a polar solvent under suitable conditions to form an emulsion. The emulsion is expanded across a pressure drop to form solid particles that include the load stock. The methods and apparatus facilitate the production of very small particles that have a narrow particle size distribution.Type: ApplicationFiled: January 30, 2004Publication date: July 6, 2006Applicant: Ferro CorporationInventors: Pratibhash Chattopadhyay, Boris Shekunov, Jeffrey Seitzinger
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Publication number: 20060138687Abstract: The present invention provides a method of forming particles that involves contacting a solution, which includes a solute and/or other material to be precipitated dissolved or dispersed in a solvent, with a first compressed or liquefied gas at an initial temperature to form a mixture. The mixture is then expanded at a first temperature to form droplets. Depending upon the composition of the droplets and the first temperature, the droplets may be in a solid state or a liquid state. The droplets are then contacted with an extracting fluid at a second temperature to extract the solvent from the droplets. The method can be used to produce micro and nanoparticles suitable for various drug delivery systems.Type: ApplicationFiled: October 15, 2004Publication date: June 29, 2006Applicant: Ferro CorporationInventors: Boris Shekunov, Pratibhash Chattopadhyay, Jeffrey Seitzinger
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Publication number: 20060104916Abstract: The present invention provides methods and apparatus for producing particles via supercritical fluid processing. In one embodiment, the method includes expanding a supercritical fluid plasticized melt across a pressure drop to form solid composite particles that are simultaneously dispersed, foamed and cooled, and milling the solid particles produced to achieve the desired size distribution. In another embodiment, a pressure vessel containing a supercritical fluid plasticized melt is depressurized to form a cooled solid porous mass, which is then milled to obtain solid composte particles.Type: ApplicationFiled: February 24, 2004Publication date: May 18, 2006Applicant: Ferro CorporationInventors: Boris Shekunov, Pratibhash Chattopadhyay, Jeffrey Seitzinger, Robert Huff
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Publication number: 20060076293Abstract: The present invention provides methods for producing composite particles using supercritical fluid as a plasticizing and extracting agent, composite particles formed in accordance with the methods and an apparatus for carrying out the methods. In accordance with the methods of the invention, a polymer, a wax and/or a lipid that is a solid at standard temperature and pressure is contacted with a supercritical fluid to form a melt, either before or after the polymer, wax and/or lipid has been contacted with a solution comprising a solute dissolved in a solvent. The supercritical fluid plasticizes the polymer, wax and/or lip and extracts the solvent from the solution, resulting in the formation of a two-fraction system including a first melt-rich fraction that includes the plasticized melt and fine particles of precipitated solute that are dispersed in the melt, and a second fraction that includes the supercritical fluid and the solvent.Type: ApplicationFiled: February 18, 2004Publication date: April 13, 2006Applicant: Ferro CorporationInventors: Boris Shekunov, Pratibhash Chattopadhyay, Jeffrey Seitzinger
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Publication number: 20060039983Abstract: The present invention provides a method of forming particles using supercritical fluid (SCF). In accordance with the method, one or more growth retardant compounds having both SCF-philic and SCF-phobic groups are present when one or more solute materials reach a supersaturation point and begin to form particle nuclei. The growth retardant compounds can reduce the particle growth rate, increase the nucleation rate and also prevent particle agglomeration. Preferred growth retardant compounds include sugar acetates and fluorocarbons.Type: ApplicationFiled: May 28, 2004Publication date: February 23, 2006Applicant: Ferro CorporationInventors: Boris Shekunov, Pratibhash Chattopadhyay, Jeffrey Seitzinger
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Publication number: 20050178020Abstract: A method and apparatus for producing particles, the apparatus includes a solution source that supplies a solution, and a fluid source that supplies a fluid. The solution includes a solvent and a solute. A mixer receives the solution and the fluid from the sources, and mixes the solution and the fluid together to form a mixture. The mixture is supplied from the mixer to an expansion assembly at first pressure. The expansion assembly sprays and expands the mixture substantially simultaneously to form frozen droplets, and preferably to form a low-density powder of frozen droplets. A freeze-dry apparatus sublimes the solvent from the particles. A high mass-transfer rate and a uniform open-structure of the powder bed enhances the freeze-drying process. Solid particles having a controlled size distribution are obtained. The particles preferably have a hollow or porous morphology suitable for differing drug delivery applications to include aerosol formulations.Type: ApplicationFiled: March 11, 2005Publication date: August 18, 2005Applicant: Ferro CorporationInventors: Boris Shekunov, Pratibhash Chattopadhyay, Jeffrey Seitzinger
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Publication number: 20050082701Abstract: The present invention provides a method and an apparatus for forming particles using supercritical fluid. The method includes the steps of mixing a load material with a first flow of a supercritical fluid in a first mixing chamber having a primary mixing device disposed therein to form a melt, transferring the melt from the first mixing chamber to a second mixing chamber having a secondary mixing device disposed therein, mixing the melt with a second flow of the supercritical fluid in the second mixing chamber to form a lower viscosity melt, expanding the lower viscosity melt across a pressure drop into an expansion chamber that is at a pressure below the critical pressure of the supercritical fluid to convert the supercritical fluid to a gas and thereby precipitate the load material in the form of particles.Type: ApplicationFiled: September 2, 2004Publication date: April 21, 2005Applicant: Ferro CorporationInventors: Boris Shekunov, Pratibhash Chattopadhyay, Jeffrey Seitzinger