Patents by Inventor Jeffrey Spees

Jeffrey Spees has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR
    Publication number: 20230285507
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Application
    Filed: January 25, 2023
    Publication date: September 14, 2023
    Applicant: The University of Vermont and State Agriculture College
    Inventor: Jeffrey SPEES
  • Methods for cardiac tissue repair with compositions comprising CTGF
    Patent number: 11576949
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: February 14, 2023
    Assignee: The University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • Compositions and methods for vascular protection against reperfusion injury after myocardial ischemia
    Patent number: 11111282
    Abstract: As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic reperfusion injury.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: September 7, 2021
    Assignee: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE
    Inventor: Jeffrey Spees
  • COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR
    Publication number: 20200338163
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Application
    Filed: April 24, 2020
    Publication date: October 29, 2020
    Applicant: University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • Composition comprising connective tissue growth factor (CTGF) for cardiac tissue repair
    Patent number: 10675329
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: June 9, 2020
    Assignee: University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • Compositions and methods for cardiac tissue repair
    Patent number: 10632153
    Abstract: The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: April 28, 2020
    Assignee: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE
    Inventor: Jeffrey Spees
  • Compositions and Methods for Vascular Protection Against Reperfusion Injury After Myocardial Ischemia
    Publication number: 20190225661
    Abstract: As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic reperfusion injury.
    Type: Application
    Filed: February 7, 2019
    Publication date: July 25, 2019
    Applicant: The University of Vermont and State Agriculture College
    Inventor: JEFFREY SPEES
  • Compositions and methods for vascular protection against reperfusion injury after myocardial ischemia
    Patent number: 10239926
    Abstract: As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic reperfusion injury.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: March 26, 2019
    Assignee: The University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • Compositions and Methods for Vascular Protection Against Reperfusion Injury After Myocardial Ischemia
    Publication number: 20180237483
    Abstract: As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic reperfusion injury.
    Type: Application
    Filed: February 23, 2016
    Publication date: August 23, 2018
    Applicant: The University of Vermont and State Agriculture College
    Inventor: JEFFREY SPEES
  • COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR
    Publication number: 20180228847
    Abstract: The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions.
    Type: Application
    Filed: January 29, 2018
    Publication date: August 16, 2018
    Applicant: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE
    Inventor: JEFFREY SPEES
  • COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR
    Publication number: 20180140671
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Application
    Filed: June 14, 2017
    Publication date: May 24, 2018
    Applicant: University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • Compositions and methods for cardiac tissue repair
    Patent number: 9913864
    Abstract: The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: March 13, 2018
    Assignee: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE
    Inventor: Jeffrey Spees
  • Methods for enhancing cardiac function with the combination of CTGF and insulin or IGF-1
    Patent number: 9707271
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: July 18, 2017
    Assignee: University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR
    Publication number: 20160067283
    Abstract: The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions.
    Type: Application
    Filed: August 14, 2015
    Publication date: March 10, 2016
    Applicant: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE
    Inventor: JEFFREY SPEES
  • COMPOSITIONS AND METHODS FOR ENHANCING CARDIAC FUNCTION
    Publication number: 20160008428
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Application
    Filed: March 7, 2014
    Publication date: January 14, 2016
    Applicant: University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • Compositions and methods for cardiac tissue repair
    Patent number: 9132155
    Abstract: The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: September 15, 2015
    Assignee: The University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR
    Publication number: 20120157381
    Abstract: The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions.
    Type: Application
    Filed: August 29, 2011
    Publication date: June 21, 2012
    Applicant: The University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • COMPOSITIONS AND METHODS FOR TISSUE REPAIR
    Publication number: 20110305673
    Abstract: The invention features compositions comprising mesenchymal stem cells or multipotent stromal cells, agents secreted by such cells in culture, and methods featuring such cells for the repair or regeneration of a damaged tissue or organ. The present invention is based, at least in part, on the discovery that agents secreted by bone marrow mesenchymal stem cells or multipotent stromal cells (MSCs) were useful for the treatment or prevention of tissue damage related to ischemic injury (e.g., cerebral or cardiac ischemia).
    Type: Application
    Filed: November 12, 2009
    Publication date: December 15, 2011
    Applicant: The University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • Enhanced growth of adult stem cells with Dkk-1
    Patent number: 7485460
    Abstract: The present invention encompasses methods and compositions for enhancing the growth of adult marrow stromal cells.
    Type: Grant
    Filed: May 21, 2003
    Date of Patent: February 3, 2009
    Assignee: Tulane University Health Sciences Center
    Inventors: Darwin Prockop, Ichiro Sekiya, Carl Gregory, Jeffrey Spees, Jason Smith, Radhika Pochampally
  • Enhanced growth of adult stem cells
    Publication number: 20040235166
    Abstract: The present invention encompasses methods and compositions for enhancing the growth of adult marrow stromal cells.
    Type: Application
    Filed: May 21, 2003
    Publication date: November 25, 2004
    Inventors: Darwin Prockop, Ichiro Sekiya, Carl Gregory, Jeffrey Spees, Jason Smith, Radhika Pochampally