Abstract: Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases.

Abstract: The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated.

Abstract: A cable card assembly includes a circuit card and cables terminated to the circuit card. Each cable has signal conductors, an insulator, and a cable shield. The cable card includes conductor holders forward of the insulators manufactured from a dielectric material and having conductor channels that receive the signal conductors. The cable card assembly includes ground shields coupled to the circuit card providing electrical shielding for the cables. Each ground shield includes a side walls and an end wall. The end wall has an end wall connecting portion coupled to the cable shield. The first side wall has a first side wall connecting portion coupled to the cable shield. The second side wall has a second side wall connecting portion coupled to the cable shield.

Abstract: A cable card assembly includes a circuit card and cables terminated to the circuit card. Each cable has signal conductors, an insulator, and a cable shield. The cable card includes conductor holders forward of the insulators manufactured from a dielectric material and having conductor channels that receive the signal conductors. The cable card assembly includes ground shields coupled to the circuit card providing electrical shielding for the cables. Each ground shield includes a side walls and an end wall. The end wall has an end wall connecting portion coupled to the cable shield. The first side wall has a first side wall connecting portion coupled to the cable shield. The second side wall has a second side wall connecting portion coupled to the cable shield.

Abstract: A pluggable module includes a housing and cables arranged as a cable bundle extending from a module cavity of the housing. Each cable includes first and second conductors and an insulator surrounding the conductors. Each cable is obround shaped having generally flat first and second ends and semi-circular first and second sides between the first and second ends. The pluggable module includes a cable organizer coupled to the cable bundle to position the cables relative to each other. The cable organizer has cable channels receiving and holding the cables such that at least a first subset of the cables are oriented with the first and second ends non-parallel to the first and second ends of a second subset of the cables.

Abstract: A light rail transit system has a railcar having a roller coaster wheel assembly, solar panels, a battery bank, an inverter, a solar charge controller, and a power rail contactor. The light rail system further has a rail system having a first riding rail and a second riding rail for receiving the roller coaster wheel assembly, and a power rail for providing backup power to the railcar via the power contactor, the power rail extending less than the length of the first riding rail and second riding rail and only supplying current when the power rail contactor of the railcar is in contact therewith.

Abstract: A network-based service may be provided for facilitating queries for a number of items, such as travel services. A user may submit a query including criteria for determining one or more relevant items. Based on the submitted query, the network-based service may present the user with information regarding the actions of other similar users of the network-based service, such as searches performed by the other users. Based on this information, the user may elect to supplement the current query to conform to the actions for other users. In some embodiments, actions by other users may be based at least in part on a category of the querying user. By presenting actions of similar users, a current user may be enabled to select the most relevant query terms for identifying a desired item.

Abstract: A pluggable module includes a housing and cables arranged as a cable bundle extending from a module cavity of the housing. Each cable includes first and second conductors and an insulator surrounding the conductors. Each cable is obround shaped having generally flat first and second ends and semi-circular first and second sides between the first and second ends. The pluggable module includes a cable organizer coupled to the cable bundle to position the cables relative to each other. The cable organizer has cable channels receiving and holding the cables such that at least a first subset of the cables are oriented with the first and second ends non-parallel to the first and second ends of a second subset of the cables.

Abstract: A top load device for disinfecting a container, such as a security bin for use in an airport, the device configured to store a stack of contaminated containers, wherein the device separates and releases a single container into an interior of a housing for disinfection. The housing comprises a conveyor that moves the container through the interior of the housing from an initial location to an exit of the housing, wherein the container is disinfected or sanitized with electromagnetic wavelength as it moves through the interior of the housing.

Abstract: A funnel wind turbine has a horizontal funnel, rotor blades in the narrower end of the funnel, the rotor blades coupled to a rotor, a shaft coupling the rotor to a generator, and a support tower. The funnel wind turbine may have bearings or a yaw system to allow rotation of the horizontal funnel on the support tower. The funnel wind turbine may have wind direction and speed sensors, an electronic control unit, and a communication device (e.g., cellular antennas, radio transmitters/receivers, etc.) for transmitting information such as wind speed and direction, power generation, and efficiency to a distant receiver.

Abstract: An adaptive communication system integrated into the wash functions of a carwash is provided. The adaptive communication system embodies a programmable input relay board coupled to a digital sound trigger board retrievably storing a plurality of communication events. Each wash function is adapted to transmit an output signal upon being engaged. The programmable input relay board is adapted to receive such output signals and interface with the digital sound trigger board so as to selectively activate one or more of the plurality of communication events.

Abstract: An electrical connector assembly includes a cable assembly having a cable bundle of cables and a conductive cable shield surrounding and providing electrical shielding for the cable bundle. The cable assembly includes an electrical connector a housing holding contacts and a conductive backshell having a cavity that receives the electrical connector to provide electrical shielding for the electrical connector. The backshell has a cable channel at a rear of the backshell that receives the cable. A ground spring is coupled to the cable and positioned between the cable bundle and the cable shield. The ground spring includes spring members engaging the inner surface of the cable shield and biasing the cable shield radially outward. The ground spring is received in the cable channel and forces the outer surface of the cable shield outward against the backshell to electrically connect the cable shield to the backshell.

Abstract: A magnetic closure system for HVAC filter grilles has at least one magnet coupled to the HVAC filter grille, the at least one magnet positioned so as to be interposed between the HVAC filter grille and an inner frame for receiving the HVAC filter grille, the magnet abutting both the filter grille and inner frame so as to magnetically couple the HVAC filter grille to the inner frame; and at least one handle on the exterior surface of the filter grille.

Abstract: An electrical connector assembly includes a cable assembly having a cable bundle of cables and a conductive cable shield surrounding and providing electrical shielding for the cable bundle. The cable assembly includes an electrical connector a housing holding contacts and a conductive backshell having a cavity that receives the electrical connector to provide electrical shielding for the electrical connector. The backshell has a cable channel at a rear of the backshell that receives the cable. A ground spring is coupled to the cable and positioned between the cable bundle and the cable shield. The ground spring includes spring members engaging the inner surface of the cable shield and biasing the cable shield radially outward. The ground spring is received in the cable channel and forces the outer surface of the cable shield outward against the backshell to electrically connect the cable shield to the backshell.

Abstract: A gaming system and a related method provide a game that includes symbol display areas and one or more cluster patterns that can be associated with two or more of the symbol display areas to create a winning outcome and one or more awards. The gaming system includes one or more symbol sets that provide symbols displayed in the symbol display areas, and a cluster pattern may be associated with a grouping of one or more of the symbol display areas. Cluster patterns of different sizes and shapes, or multiple similar shaped and sized cluster patterns positioned in different locations may be used. The gaming system evaluates symbols displayed in a grouping of the symbol display areas associated with a cluster pattern to determine an award. The gaming system may further evaluate the symbol display areas to determine other awards associated with the displayed symbols.

Abstract: A funnel wind turbine has a horizontal funnel, rotor blades in the narrower end of the funnel, the rotor blades coupled to a rotor, a shaft coupling the rotor to a generator, and a support tower. The funnel wind turbine may have bearings or a yaw system to allow rotation of the horizontal funnel on the support tower. The funnel wind turbine may have wind direction and speed sensors, an electronic control unit, and a communication device (e.g., cellular antennas, radio transmitters/receivers, etc.) for transmitting information such as wind speed and direction, power generation, and efficiency to a distant receiver.

Abstract: A funnel wind turbine has a horizontal funnel, rotor blades in the narrower end of the funnel, the rotor blades coupled to a rotor, a shaft coupling the rotor to a generator, and a support tower. The funnel wind turbine may have bearings or a yaw system to allow rotation of the horizontal funnel on the support tower. The funnel wind turbine may have wind direction and speed sensors, an electronic control unit, and a communication device (e.g., cellular antennas, radio transmitters/receivers, etc.) for transmitting information such as wind speed and direction, power generation, and efficiency to a distant receiver.

Abstract: Internet of thing (IoT) endpoints may be enabled to serve as a limited or wide-area public warning device.

Abstract: An atmospheric water generation apparatus has an intake fan, a water mister, a cooling or evaporative coil, a water reservoir, a water pump, and a water valve. A method of generating water from the atmosphere involves inducing air into a chamber, misting the air with water while the air passes a cooling or evaporative coil, and collecting the resulting water therefrom.

Abstract: An atmospheric water generation apparatus has an intake fan, a water mister, a cooling or evaporative coil, a water reservoir, a water pump, and a water valve. A method of generating water from the atmosphere involves inducing air into a chamber, misting the air with water while the air passes a cooling or evaporative coil, and collecting the resulting water therefrom.