Abstract: Disclosed are prodrugs of myeloperoxidase (MPO) inhibitors, methods of treating MPO related disorders, e.g., multiple system atrophy, amyotrophic lateral sclerosis, and Huntington's disease, and methods of neuroprotection, which include administering to a patient in need thereof the prodrugs, pharmaceutical compositions including the prodrugs, and kits including the pharmaceutical compositions and instructions for use.

Abstract: The invention includes systems and methods for conducting online contests of user-contributed media works and entertainment works. The invention includes anti-gaming or anti-cheating methods in such contests. The invention includes a method of providing an online media network for user-contributed content. The system quickly and accurately identifies quality content from a vast pool of user-contributed content. User-contributed content is rated by those who contribute and those who view content. Good entries bubble to the top, which means that users can find good music and videos easily. Fraud detection devices automatically detect and remove fraudulent ratings. Contests and prizes associated with specific categories of content provide incentives for contributors to provide quality content and rate many pairs of works. Identified top-rated content is made available individually, or as a continuous stream of user-contributed content.