Abstract: Methods of fabricating microfluidic structures featuring substantially circular channels are provided. The methods involve (a) providing a patterned wafer comprising at least one exposed electrically conductive region and at least one exposed electrically insulating region; (b) electroplating an inverse channel portion with substantially semicircular cross section onto the wafer, thereby forming a first master mold; (c) employing the first master mold so as to emboss a channel portion in a first polymer sheet; and (d) aligning and bonding the first polymer sheet with a second polymer sheet having a corresponding channel portion such as to define a first channel with substantially circular cross section between the polymer sheets.

Abstract: Biodegradable electronic devices may include a biodegradable semiconducting material and a biodegradable substrate layer for providing mechanical support to the biodegradable semiconducting material.

Abstract: The invention provides microfluidic devices, methods for imaging cells, and methods for preparing such microfluidic devices. The microfluidic devices are contemplated to provide advantages for use in imaging of cells and subcellular compartments in an environment that mimics in vivo conditions. The microfluidic devices can used with a microscope equipped with an oil emersion objective lens.

Abstract: In various embodiments, microengineered phantoms with microvascular networks serve as calibration standards for perfusion imaging systems.

Abstract: The present invention relates to tissue engineered compositions and methods comprising nanotopographic surface topography (“nanotopography”) for use in modulating the organization and/or function of multiple cell types.

Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.

Abstract: A method for detecting one or more metabolites of a test agent in a tissue including: A) incubating a test agent and an enzyme within a three-dimensional structure comprising a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, and wherein the first mold or polymer scaffold has microchannels that form a fluidic branching network that mimics the forces and transport of natural vasculatures and wherein the second mold or polymer scaffold comprises cells; B) forming an enzyme-substrate complex between the enzyme and the test agent; and C) detecting one or more metabolites of the test agent.

Abstract: The present invention relates to tissue engineered compositions and methods comprising nanotopographic surface topography (“nanotopography”) for use in modulating the organization and/or function of multiple cell types.

Abstract: The invention provides systems and methods for exchanging gas in an oxygenator device, and methods for preparing and using such oxygenator devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient.

Abstract: The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.

Abstract: Microfluidic devices may be fabricated from thermoplastics using, for example, hot embossing techniques. In some embodiments, the devices feature non-uniform surface modifications.

Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.

Abstract: The invention provides microfluidic devices and methods of using such devices for filtering solutions, such as blood.

Abstract: The invention provides systems and methods for exchanging gas in a microfluidic device, and methods for preparing such microfluidic devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient.

Abstract: The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.

Abstract: Microfluidic bioreactor devices may feature intercommunicating microchannels defined in two polymer layers separated by a membrane. A geometric parameter associated with the microchannels in one layer may vary along a length of those channels.

Abstract: Methods and materials for making an apparatus which duplicates the functionality of a physiological system is provided.

Abstract: The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.

Abstract: Disclosed are various methods and bioreactor devices for culturing retinal cells and/or tissues. The bioreactor devices may, in certain embodiments, include a microchannel network, a scaffold for culturing neuroretinal cells, and a porous membrane separating the microchannel network from the scaffold.

Abstract: In one embodiment, a high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern.