Patents by Inventor Jeffrey T. Fayerman

Jeffrey T. Fayerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA sequences encoding porcine pancreatic carboxypeptidase B
    Patent number: 5672496
    Abstract: DNA encoding porcine Pro-carboxypeptidase B, vectors comprising the DNA and host cells transformed with the vectors are useful for production of porcine carboxypeptidase B
    Type: Grant
    Filed: August 13, 1996
    Date of Patent: September 30, 1997
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey T. Fayerman, David P. Greenen, Charles L. Hershberger, Jeffrey L. Larson, Jane L. Sterner, Haichao Zhang
  • Methods for transforming streptomyces and other actinomycetes
    Patent number: 5393665
    Abstract: Novel vectors and methods for a single-stranded DNA mediated gene transfer system via transformation, fusion or transduction of Streptomyces, other actinomycetes, and E. coli using a variety of vectors. Phasmid shuttle vectors of the invention are particularly useful as single-stranded vectors that appear to bypass one or more host cell restriction systems, and thus increase the efficiency of gene transfer into highly restrictive host cell systems. New and useful vectors are provided that allow for the cloning of genes both for increasing the yields of known antibiotics and also for producing new antibiotics, antibiotic derivatives, or any other useful gene product, including a variety of mammalian protein products.
    Type: Grant
    Filed: February 10, 1992
    Date of Patent: February 28, 1995
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey T. Fayerman, Richard K. Stanzak
  • Process for producing antibiotic A47934
    Patent number: 4880735
    Abstract: Improved fermentation process for producing the Gram-positive antibiotic A47934 which comprises cultivating a new strain of Streptomyces toyocaensis, NRRL 18112, and a biologically purified culture of this microorganism are provided.
    Type: Grant
    Filed: September 24, 1986
    Date of Patent: November 14, 1989
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey T. Fayerman, Michael D. Jones, Karl H. Michel, Raymond C. Yao, Milton J. Zmijewski
  • Method for using a novel transcriptional- and translational-activating sequence in streptomyces
    Patent number: 4752577
    Abstract: The present invention is a method for expressing functional polypeptides in Streptomyces using a recombinant DNA expression vector comprising a novel transcriptional- and translational- activating sequence. The novel activating sequence can be synthesized by conventional methods and used in Streptomyces expression vectors. One such vector, plasmid pFJ350, expresses and confers hygromycin resistance in Streptomyces host cells.
    Type: Grant
    Filed: September 13, 1984
    Date of Patent: June 21, 1988
    Assignee: Eli Lilly and Company
    Inventors: Ramamoorthy Belagaje, Jeffrey T. Fayerman, Mark A. Richardson
  • Novel cloning vectors containing selectable genetic markers for use in streptomyces and related organisms
    Patent number: 4666846
    Abstract: The present invention discloses novel recombinant DNA cloning vectors for use in Streptomyces and related organisms. These novel cloning vectors contain genetic markers that provide antibiotic resistance or colorimetric selectivity to the host cells. The invention further comprises transformants of the aforementioned vectors.
    Type: Grant
    Filed: February 17, 1984
    Date of Patent: May 19, 1987
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey T. Fayerman, Michael D. Jones, Nancy E. Malin
  • Novel cloning vectors for use in streptomyces, escherichia coli and related organisms
    Patent number: 4643975
    Abstract: The present invention discloses novel selectable recombinant DNA cloning vectors for use in Streptomyces, E. coli and related organisms. The invention further comprises transformants of the aforementioned vectors.
    Type: Grant
    Filed: January 5, 1984
    Date of Patent: February 17, 1987
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey T. Fayerman, Nancy E. Malin
  • Method for using an homologous bacillus promoter and associated natural or modified ribosome binding site-containing DNA sequence in streptomyces
    Patent number: 4559300
    Abstract: A method for expressing a functional polypeptide in Streptomyces comprises transforming a Streptomyces host cell with a recombinant DNA expression vector and then culturing the transformed cell under conditions suitable for cell growth. The recombinant DNA expression vector comprises the veg or any other homologous Bacillus promoter, a naturally occurring or modified ribosome binding site-containing DNA sequence and a gene that codes for a functional polypeptide such as human pre-proinsulin. The method is specifically exemplified by use of expression plasmids pOW529, pOW539 and transformants, Streptomyces ambofaciens/pOW529 and Streptomyces ambofaciens/pOW539. The method is broadly applicable and is particularly useful in economically important Streptomyces taxa.
    Type: Grant
    Filed: January 18, 1983
    Date of Patent: December 17, 1985
    Assignee: Eli Lilly and Company
    Inventors: Steven Kovacevic, Jeffrey T. Fayerman, James R. Miller, Mark A. Richardson
  • Cloning vectors for use in streptomyces and related organisms
    Patent number: 4513086
    Abstract: The present invention discloses selectable recombinant DNA cloning vectors for use in Streptomyces and related organisms.
    Type: Grant
    Filed: August 2, 1982
    Date of Patent: April 23, 1985
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey T. Fayerman, Mark A. Richardson
  • Multifunctional, cloning vectors for use in Streptomyces, Bacillus, and E. coli
    Patent number: 4503155
    Abstract: The present invention discloses multifunctional recombinant DNA cloning vectors for use in Streptomyces, Bacillus, and E. coli. The invention further discloses transformants of the aforementioned vectors.
    Type: Grant
    Filed: February 1, 1982
    Date of Patent: March 5, 1985
    Assignee: Eli Lilly and Company
    Inventors: James R. Miller, Jeffrey T. Fayerman, Steven Kovacevic, Nancy E. Beerman
  • Vectors for cloning in streptomyces
    Patent number: 4468462
    Abstract: The present invention discloses selectable recombinant DNA cloning vectors for use in Streptomyces.
    Type: Grant
    Filed: December 22, 1982
    Date of Patent: August 28, 1984
    Assignee: Eli Lilly and Company
    Inventors: Nancy E. Malin, Jeffrey T. Fayerman, Michael D. Jones, James A. Mabe, Walter M. Nakatsukasa
  • Plasmid pEL7 and related cloning vectors for use in streptomyces and related organisms
    Patent number: 4416994
    Abstract: The present invention discloses selectable pairs of recombinant DNA cloning vectors for use in Streptomyces and related organisms.
    Type: Grant
    Filed: October 19, 1981
    Date of Patent: November 22, 1983
    Assignee: Eli Lilly and Company
    Inventors: Walter M. Nakatsukasa, Jeffrey T. Fayerman, James A. Mabe