Patents by Inventor Jeffrey T. Koberstein
Jeffrey T. Koberstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11331392Abstract: The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble, pH-degradable and have tunable lower critical solution temperatures. Other aspects of the invention include micelles and gels comprising the thermo-responsive polymers and derivatives thereof, as well as methods of delivering therapeutic agents comprising administering a biodegradable gel or micelle comprising a polyacetal compound cross-linked with a linker.Type: GrantFiled: December 3, 2015Date of Patent: May 17, 2022Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jeffrey T. Koberstein, Sanjoy Samanta, Chathuranga De Silva
-
Publication number: 20210355276Abstract: Disclosed herein are ketal compounds, oligomers, and polyketals that are obtained in both high purity and high yield. These ketals and polyketals are utilized for their ability to readily release small chemical molecules, preferably fragrance molecules. Also disclosed are the utility of ketals and polyketals as delivery vehicles for controlled release of fragrances over time and/or on demand.Type: ApplicationFiled: September 16, 2019Publication date: November 18, 2021Inventors: Chathuranga C. DE SILVA, Porakrit LEOPHAIRATANA, Jeffrey T. KOBERSTEIN
-
Publication number: 20180133333Abstract: The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble, pH-degradable and have tunable lower critical solution temperatures. Other aspects of the invention include micelles and gels comprising the thermo-responsive polymers and derivatives thereof, as well as methods of delivering therapeutic agents comprising administering a biodegradable gel or micelle comprising a polyacetal compound cross-linked with a linker.Type: ApplicationFiled: December 3, 2015Publication date: May 17, 2018Applicant: Tht Trustees of Columbia University in the City of New YorkInventors: Jeffrey T. KOBERSTEIN, Sanjoy SAMANTA, Chathuranga DE SILVA
-
Patent number: 9454077Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.Type: GrantFiled: January 5, 2015Date of Patent: September 27, 2016Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Gregory T. Carroll, Jeffrey T. Koberstein, Denong Wang, Nicholas J. Turro
-
Publication number: 20160231649Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.Type: ApplicationFiled: January 5, 2015Publication date: August 11, 2016Inventors: Gregory T. CARROLL, Jeffrey T. KOBERSTEIN, Denong WANG, Nicholas J. TURRO
-
Patent number: 9296870Abstract: Methods for functionalizing a surface of a substrate with nanoparticles are described. In certain embodiments, the method can include attaching a plurality of photoactive linker to nanoparticles to obtain photoactive nanoparticles, wherein each photoactive linker comprises a binding group that attaches to the nanoparticles and a photoactive group; depositing the photoactive nanoparticles to the surface of the substrate, wherein the surface of the substrate comprises reactive groups that are capable of reacting with the photoactive groups; and irradiating the photoactive nanoparticles with radiation to react the photoactive group with the reactive group and to functionalize the surface of the substrate with nanoparticles.Type: GrantFiled: July 27, 2010Date of Patent: March 29, 2016Assignee: The Trustees of Columbia University in the City of New YorkInventors: Ellane J. Park, Nicholas J. Turro, Jeffrey T. Koberstein
-
Publication number: 20160075814Abstract: In one aspect, the present invention is directed to methods for modification of functionalized substrates. In another aspect, the invention relates to systems and methods for fabricating multilayer polymer compositions. In certain embodiments, the multilayer polymer compositions described herein can comprise heterobifunctional polymers and heterotrifunctional molecules.Type: ApplicationFiled: March 17, 2015Publication date: March 17, 2016Inventors: Jeffrey T. KOBERSTEIN, Hernan R. RENGIFO, Cristian GRIGORAS, Jeffrey LANCASTER
-
Patent number: 9200097Abstract: The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.Type: GrantFiled: October 21, 2014Date of Patent: December 1, 2015Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Jeremiah Johnson, Jeffrey T. Koberstein, Nicholas J. Turro
-
Publication number: 20150299344Abstract: The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.Type: ApplicationFiled: October 21, 2014Publication date: October 22, 2015Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremiah Johnson, Jeffrey T. Koberstein, Nicholas J. Turro
-
Patent number: 9006345Abstract: In one aspect, the present invention is directed to dendrimers comprised of macromolecules and trifunctional branches. In another aspect, the invention relates to methods for generating dendrimeric compositions comprising macromolecules and trifunctional branches. In certain embodiments, the radial density of the dendrimeric composition is controlled by selective incorporation of branches.Type: GrantFiled: March 26, 2012Date of Patent: April 14, 2015Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jeffrey Lancaster, Jeffrey T. Koberstein, Nicholas J. Turro
-
Patent number: 8993068Abstract: In one aspect, the present invention is directed to methods for modification of functionalized substrates. In another aspect, the invention relates to systems and methods for fabricating multilayer polymer compositions. In certain embodiments, the multilayer polymer compositions described herein can comprise heterobifunctional polymers and heterotrifunctional molecules.Type: GrantFiled: November 4, 2009Date of Patent: March 31, 2015Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jeffrey T. Koberstein, Hernan R. Rengifo, Cristian Grigoras, Jeffrey Lancaster
-
Patent number: 8957225Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.Type: GrantFiled: March 9, 2012Date of Patent: February 17, 2015Assignee: The Trustees of Columbia University in the City of New YorkInventors: Gregory T. Carroll, Jeffrey T. Koberstein, Denong Wang, Nicholas J. Turro
-
Patent number: 8895673Abstract: The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.Type: GrantFiled: February 19, 2013Date of Patent: November 25, 2014Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jeremiah Johnson, Jeffrey T. Koberstein, Nicholas J. Turro
-
Patent number: 8658573Abstract: The invention relates to novel photo-generated carbohydrate arrays and methods of their use to detect the presence of one or more agents in a sample. The invention also relates to a high-throughput strategy to facilitate the identification and immunological characterization of pathogen-specific carbohydrates, including those of Bacillus anthracis. The invention can be used to determine the presence of a pathogen and whether a subject has been exposed to a pathogen, such as by screening for pathogen-specific antibodies.Type: GrantFiled: September 11, 2007Date of Patent: February 25, 2014Assignee: The Trustees of Columbia University in the City of New YorkInventors: Denong Wang, Gregory T. Carroll, Nicholas J. Turro, Jeffrey T. Koberstein
-
Patent number: 8507572Abstract: The present invention relates to functionalizing a surface of an organic material. For example, surfaces of materials having C—H bonds, such as polymers having C—H bonds, can be functionalized. In certain embodiments, a heterobifunctional molecule having a photoactive anchor, a spacer, and a terminal functional group is applied to the surface of an organic material that contains one or more C—H bonds. The heterobifunctional molecule can be bound to any surface having C—H bonds as the photoactive anchor can react with C—H bonds upon irradiation. The terminal functional group has a “click” functionality which can be utilized to functionalize the surface of the organic material with any desired functionalizing moiety having the orthogonal click functionality.Type: GrantFiled: June 8, 2010Date of Patent: August 13, 2013Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jeffrey Lancaster, Nicholas J. Turro, Jeffrey T. Koberstein
-
Publication number: 20130171461Abstract: In one aspect, the present invention is directed to methods for fabricating multilayer polymacromer compositions. In some embodiments, the multilayer polymacromer compositions described herein can comprise heterobifunctional macromolecules and heterotrifunctional molecules.Type: ApplicationFiled: August 13, 2012Publication date: July 4, 2013Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Benjamin I. Dach, Jeffrey T. Koberstein, Sandra Turro
-
Patent number: 8378041Abstract: The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization CLICK chemistry and a tetrafunctional initiator having terminal halogen groups to form the desired product.Type: GrantFiled: January 30, 2009Date of Patent: February 19, 2013Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jeremiah Johnson, Jeffrey T. Koberstein, Nicholas J. Turro
-
Publication number: 20120264881Abstract: In one aspect, the present invention is directed to dendrimers comprised of macromolecules and trifunctional branches. In another aspect, the invention relates to methods for generating dendrimeric compositions comprising macromolecules and trifunctional branches. In certain embodiments, the radial density of the dendrimeric composition is controlled by selective incorporation of branches.Type: ApplicationFiled: March 26, 2012Publication date: October 18, 2012Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: JEFFREY LANCASTER, JEFFREY T. KOBERSTEIN, NICHOLAS J. TURRO
-
Patent number: 8263192Abstract: The invention is directed to methods for coating monolayer films of surface-active polymers onto substrates of arbitrary shape, and molecular-based methods and processes to control the chemical and physical nature of surfaces and interfaces. The invention is also directed to methods for modifying a surface of a monolayer comprising a) coating a monolayer on a substrate, wherein the monolayer is formed by self-assembly of end-surfactant molecules, thereby positioning a photoactive functional group at the air-monolayer interface; and b) exposing the monolayer to radiation, wherein each organic group of the monolayer contains a first functionality that is not converted to a second functionality upon exposure to acid.Type: GrantFiled: June 16, 2006Date of Patent: September 11, 2012Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jeffrey T. Koberstein, Peng Wang, Feng Pan
-
Publication number: 20120178650Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.Type: ApplicationFiled: March 9, 2012Publication date: July 12, 2012Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Gregory T. Carroll, Jeffrey T. Koberstein, Denong Wang, Nicholas J. Turro