Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: The present disclosure generally relates to a flexible frame for use with a flexible container. The frame includes a first member coupled to a second member at a proximal end. The proximal end is configured to be adjacent to a base of the flexible container when the flexible container is received by the frame. The first and second members are configured to provide additional resistance against displacement of the flexible container by an external compression force to increase purchase and control when using the flexible container. In some embodiments, the frame may also assist in efficiently restoring the shape of the flexible container after the compression force is applied and/or provide feedback regarding the extent of the compressive force applied or contortion experienced by the flexible container.

Abstract: An eye dropper includes a nozzle secured to a reservoir. The nozzle includes a sleeve that extends around the center and has a first zone, a second zone, and a third zone, having corresponding first, second, and third expansion pressures at which the first, second and third zones separate from the center. The second pressure is less than the first expansion pressure and the third expansion pressure is less than the second expansion pressure. The third expansion pressure may be less than the first expansion pressure. A notch in the sleeve may receive a ridge on the center. The zones may be positioned over a groove in the center or extend completely around a center that is cylindrical or frusto-conical in shape. Multiple instances of first, second and third zones may be distributed along the center. The sleeve may be made of a more flexible material than the center.