Patents by Inventor Jeffrey V. Ravetch

Jeffrey V. Ravetch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES TO CD40 WITH ENHANCED AGONIST ACTIVITY
    Publication number: 20240026021
    Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for Fc?RIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
    Type: Application
    Filed: July 31, 2023
    Publication date: January 25, 2024
    Inventors: Jeffrey V. Ravetch, Rony Dahan
  • IMMUNE COMPLEX
    Publication number: 20230338505
    Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.
    Type: Application
    Filed: May 18, 2023
    Publication date: October 26, 2023
    Applicant: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Taia Wang, Jad Mamaary
  • Anti-Inflammatory Polypeptides
    Publication number: 20230295306
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Application
    Filed: February 22, 2023
    Publication date: September 21, 2023
    Applicant: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • Antibodies to CD40 with enhanced agonist activity
    Patent number: 11760805
    Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for Fc?RIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: September 19, 2023
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Jeffrey V. Ravetch, Rony Dahan
  • Immune complex
    Patent number: 11690905
    Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: July 4, 2023
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Taia Wang, Jad Mamaary
  • Polypeptides With Enhanced Anti-Inflammatory And Decreased Cytotoxic Properties And Relating Methods
    Publication number: 20230121427
    Abstract: The invention provides a polypeptide containing at least one IgG Fc region region, said polypeptide having a higher anti-inflammatory activity and a lower cytotoxic activity as compared to an unpurified antibody and methods of production of such polypeptide.
    Type: Application
    Filed: December 20, 2022
    Publication date: April 20, 2023
    Inventors: Jeffrey V. Ravetch, Yoshikatsu Kaneko, Falk Nimmerjahn
  • Anti-inflammatory polypeptides
    Patent number: 11613579
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: March 28, 2023
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • Anti-inflammatory polypeptides
    Patent number: 11608379
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: March 21, 2023
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • HUMAN IgG Fc DOMAIN VARIANTS WITH IMPROVED EFFECTOR FUNCTION
    Publication number: 20230057150
    Abstract: The present invention relates to human IgG Fc domain variants with improved effector function and uses thereof.
    Type: Application
    Filed: March 21, 2022
    Publication date: February 23, 2023
    Applicant: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Stylianos Bournazos
  • ANTIBODIES AND METHODS FOR TREATMENT OF VIRAL INFECTIONS
    Publication number: 20220298230
    Abstract: The present invention provides antibodies that are capable of activating dendritic cell maturation and/or inducing a protective CDS response. The disclosed antibodies can be used to treat or inhibit viral infections, including prophylaxis and treatment of influenza A infection. The invention also provides nucleic acids that encode and immortalized B cells and cultured plasma cells that produce such antibodies.
    Type: Application
    Filed: June 4, 2020
    Publication date: September 22, 2022
    Applicant: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Stylianos Bournazos
  • IMMUNE COMPLEX
    Publication number: 20210228706
    Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.
    Type: Application
    Filed: April 9, 2021
    Publication date: July 29, 2021
    Applicant: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Taia Wang, Jad Mamaary
  • ANTIBODIES TO CD40 WITH ENHANCED AGONIST ACTIVITY
    Publication number: 20210139598
    Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for Fc?RIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
    Type: Application
    Filed: January 15, 2021
    Publication date: May 13, 2021
    Inventors: Jeffrey V. Ravetch, Rony Dahan
  • ANTI-INFLAMMATORY POLYPEPTIDES
    Publication number: 20210130472
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Application
    Filed: November 20, 2020
    Publication date: May 6, 2021
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • Immune complex
    Patent number: 10973904
    Abstract: The present invention relates to immunogenic immune complexes, related compositions, and related methods.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: April 13, 2021
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Taia Wang, Jad Mamaary
  • ANTI-INFLAMMATORY POLYPEPTIDES
    Publication number: 20210101986
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Application
    Filed: November 25, 2020
    Publication date: April 8, 2021
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • Anti-inflammatory polypeptides
    Patent number: 10894832
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: January 19, 2021
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic
  • Antibodies to CD40 with enhanced agonist activity
    Patent number: 10894835
    Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for Fc?RIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: January 19, 2021
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Rony Dahan
  • Anti-tumor agents and methods of use
    Patent number: 10882917
    Abstract: The present invention relates to anti-tumor agents that target certain tumor-associated macrophages. Also disclosed are methods of using such agents in treatment of cancer.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: January 5, 2021
    Assignee: The Rockefeller University
    Inventors: Mikael Karlsson, Jeffrey V. Ravetch
  • Polypeptides With Enhanced Anti-Inflammatory And Decreased Cytotoxic Properties And Relating Methods
    Publication number: 20200385443
    Abstract: The invention provides a polypeptide containing at least one IgG Fc region region, said polypeptide having a higher anti-inflammatory activity and a lower cytotoxic activity as compared to an unpurified antibody and methods of production of such polypeptide.
    Type: Application
    Filed: December 20, 2019
    Publication date: December 10, 2020
    Inventors: Jeffrey V. Ravetch, Yoshikatsu Kaneko, Falk Nimmerjahn
  • Anti-inflammatory polypeptides
    Patent number: 10851167
    Abstract: This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: December 1, 2020
    Assignee: The Rockefeller University
    Inventors: Jeffrey V. Ravetch, Andrew Pincetic