Abstract: The present disclosure relates to novel methods for detection of nucleic acid sequences.

Abstract: The invention provides articles of manufacture having a surface of a boronic acid-containing siloxane polymer bonded to a cellulose-containing material. The invention further provides methods of making such articles of manufacture. The surface of the cellulose-containing material covered by the bonded boronic acid-containing siloxane polymer is hydrophobic and keeps water from soaking into the article of manufacture. In some embodiments, the invention provides analytic devices in which a hydrophobic coating is applied to a material to defining one or more channels. The one or more channels may contain reagents that can react with analytes if the analytes are present in fluids introduced into the one or more channels.

Abstract: The present invention relates to novel devices and methods for viral lysis and isolation as well as a simple, disposable, and nonenzymatic viral load assay based on a hairpin cascade reaction (HCR).