Patents by Inventor Jeffrey Wade Harper

Jeffrey Wade Harper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin
    Patent number: 10350264
    Abstract: Described herein are methods of modulating autophagic targeting of ferritin in a cell, wherein the method comprises modulating the level and/or activity of nuclear receptor coactivator 4 (NCOA4) in the cell. Also provided are related methods of treatment.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: July 16, 2019
    Assignees: Dana-Farber Cancer Institute, Inc., President and Fellows of Harvard College, Beth Israel Deaconess Medical Center, Inc., The Brigham & Women's Hospital, Inc.
    Inventors: Alec C. Kimmelman, Joseph D. Mancias, Jeffrey Wade Harper
  • Compositions And Methods For Modulating NCOA4-Mediated Autophagic Targeting Of Ferritin
    Publication number: 20170182119
    Abstract: Described herein are methods of modulating autophagic targeting of ferritin in a cell, wherein the method comprises modulating the level and/or activity of nuclear receptor coactivator 4 (NCOA4) in the cell. Also provided are related methods of treatment.
    Type: Application
    Filed: March 27, 2015
    Publication date: June 29, 2017
    Inventors: Alec C. Kimmelman, Joseph D. Mancias, Jeffrey Wade Harper
  • Novel Activation and Transfer Cascade for Ubiquitin
    Publication number: 20150105446
    Abstract: A novel activating enzyme for ubiquitin, Uba6, is provided. Compositions and methods for inhibiting ubiquitin via the Uba6 pathway are provided. Methods of identifying novel inhibitors of ubiquitination are also provided. Novel RNAi molecules are also provided.
    Type: Application
    Filed: August 26, 2014
    Publication date: April 16, 2015
    Inventors: Jeffrey Wade HARPER, Jianping JIN
  • Activation and transfer cascade for ubiquitin
    Patent number: 8846360
    Abstract: A novel activating enzyme for ubiquitin, Uba6, is provided. Compositions and methods for inhibiting ubiquitin via the Uba6 pathway are provided. Methods of identifying novel inhibitors of ubiquitination are also provided. Novel RNAi molecules are also provided.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: September 30, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: Jeffrey Wade Harper, Jianping Jin
  • Novel Activation and Transfer Cascade for Ubiquitin
    Publication number: 20120302623
    Abstract: A novel activating enzyme for ubiquitin, Uba6, is provided. Compositions and methods for inhibiting ubiquitin via the Uba6 pathway are provided. Methods of identifying novel inhibitors of ubiquitination are also provided. Novel RNAi molecules are also provided.
    Type: Application
    Filed: May 9, 2012
    Publication date: November 29, 2012
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: JEFFREY WADE HARPER, JIANPING JIN
  • Activation and transfer cascade for ubiquitin
    Patent number: 8198059
    Abstract: A novel activating enzyme for ubiquitin, Uba6, is provided. Compositions and methods for inhibiting ubiquitin via the Uba6 pathway are provided. Methods of identifying novel inhibitors of ubiquitination are also provided. Novel RNAi molecules are also provided.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: June 12, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: Jeffrey Wade Harper, Jianping Jin
  • NOVEL ACTIVATION AND TRANSFER CASCADE FOR UBIQUITIN
    Publication number: 20100047255
    Abstract: A novel activating enzyme for ubiquitin, Uba6, is provided. Compositions and methods for inhibiting ubiquitin via the Uba6 pathway are provided. Methods of identifying novel inhibitors of ubiquitination are also provided. Novel RNAi molecules are also provided.
    Type: Application
    Filed: July 7, 2009
    Publication date: February 25, 2010
    Inventors: Jeffrey Wade Harper, Jianping Jin
  • F-box proteins and genes
    Publication number: 20040166530
    Abstract: The present invention provides compositions and methods for gene identification, as well as drug discovery and assessment. In particular, the present invention provides components of an E3 complex involved in ubiquitination of cell cycle regulators and other proteins, as well as members of a class of proteins that directly function in recognition of ubiquitination targets. The present invention also provides sequences of multiple F-box proteins.
    Type: Application
    Filed: March 7, 2001
    Publication date: August 26, 2004
    Inventors: Jeffrey Wade Harper, Stephen J. Elledge, Jeffrey T. Winston
  • F-box genes and proteins
    Patent number: 6573094
    Abstract: The present invention provides compositions and methods for gene identification, as well as drug discovery and assessment. In particular, the present invention provides components of an E3 complex involved in ubiquitination of cell cycle regulators and other proteins, as well as members of a class of proteins that directly function in recognition of ubiquitination targets. The present invention also provides sequences of multiple F-box proteins.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: June 3, 2003
    Assignee: Baylor College of Medicine
    Inventors: Jeffrey Wade Harper, Stephen J. Elledge
  • Method for the detection of NF-&kgr;B regulatory factors
    Patent number: 6232081
    Abstract: The present invention provides compositions and methods for gene identification, as well as drug discovery and assessment. In particular, the present invention provides components of an E3 complex involved in ubiquitination of cell cycle regulators and other proteins, as well as members of a class of proteins that directly function in recognition of ubiquitination targets. The present invention also provides sequences of multiple F-box proteins.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: May 15, 2001
    Assignee: Baylor College of Medicine
    Inventors: Jeffrey Wade Harper, Stephen J. Elledge, Jeffrey T. Winston