Abstract: A novel activating enzyme for ubiquitin, Uba6, is provided. Compositions and methods for inhibiting ubiquitin via the Uba6 pathway are provided. Methods of identifying novel inhibitors of ubiquitination are also provided. Novel RNAi molecules are also provided.

Abstract: An anterior fixation system includes a plate defining a plurality of screw holes, a number of screws and a number of locking assemblies for fixing the screws to the plate. The system includes two bone screws, a fixed angle screw and a variable angle screw, that are configured to extend through the same screw openings in the fixation plate. The surgeon can select either the fixed or variable angled screws to be implanted with a single plate and can place either type of screw into any of the screw holes along the plate. The fixation plate can include several screw holes in various patterns that provide the surgeon with great flexibility in the placement of bone screws depending upon the spinal anatomy and pathology. Also contemplated is a locking assembly to lock one or more bone screws within a respective screw hole.

Abstract: A novel activating enzyme for ubiquitin, Uba6, is provided. Compositions and methods for inhibiting ubiquitin via the Uba6 pathway are provided. Methods of identifying novel inhibitors of ubiquitination are also provided. Novel RNAi molecules are also provided.

Abstract: A method and system provide a plurality of femto cells that are deployed within a macro cell of cellular network. The femto cells improve cellular service inside structures, such as residential and commercial structures. Femto base stations convert signals between an airlink-interface and core network to enable data communication between the mobile terminal and an access network to occur through the Internet and a public switched telephone network. The femto base stations are independent of each other and the macro cell. The method and system provide the femto base stations with interference awareness and mitigation techniques to minimize interference with the cellular network.

Abstract: A posterior fixation system includes a saddle member, an anchoring member, an occipital plate, an occipital rod, and a cross-link connector. The anchoring member anchors the saddle member to bone. The saddle member includes a pair of upright portions that define a channel. The channel is adapted to receive an orthopedic rod, and the saddle member can include a hole to receive the anchoring member. The saddle member and the anchoring member can be coupled so as to allow multi-axial movement of the members. The anchoring member in one embodiment is a screw coupled to the hole of the saddle, and in another embodiment, the anchoring member is a hook. The offset member may be coupled to the saddle member to allow for offset connection of rods. Connection of individual rods can be accomplished by connecting the rods with the cross-link connector. The cross-link connector has an integrally formed cylindrical member that couples a pair of coupling portions together.

Abstract: A thermal regulatory system to reduce swelling caused by trauma to a variety of tissues and limbs is provided. One or more substantially flexible, at least partially thermally conductive housing containing optionally activatable thermal regulatory medium may be coupled with one or more applicator, such as a splint, that is adapted to apply the medium housing to the tissue. Methods of therapeutically regulating tissue temperature are also provided.

Abstract: A posterior fixation system includes a saddle member, an anchoring member, an occipital plate, an occipital rod, and a cross-link connector. The anchoring member anchors the saddle member to bone. The saddle member includes a pair of upright portions that define a channel. The channel is adapted to receive an orthopedic rod, and the saddle member can include a hole to receive the anchoring member. The saddle member and the anchoring member can be coupled so as to allow multi-axial movement of the members. The anchoring member in one embodiment is a screw coupled to the hole of the saddle, and in another embodiment, the anchoring member is a hook. The offset member may be coupled to the saddle member to allow for offset connection of rods. Connection of individual rods can be accomplished by connecting the rods with the cross-link connector. The cross-link connector has an integrally formed cylindrical member that couples a pair of coupling portions together.

Abstract: A novel activating enzyme for ubiquitin, Uba6, is provided. Compositions and methods for inhibiting ubiquitin via the Uba6 pathway are provided. Methods of identifying novel inhibitors of ubiquitination are also provided. Novel RNAi molecules are also provided.

Abstract: A posterior fixation system includes a saddle member and an anchoring member. The anchoring member anchors the saddle member to bone. The saddle member includes a pair of upright portions that define a channel. The saddle member further has a hole therethrough bounded by an inner wall, and the hole forms a lower opening in the saddle member. The lower opening in the saddle member may contain angular cutouts placed symmetrically about the axis of the saddle to increase the allowable angulation of the bone screw in relationship to the axis of the saddle. The channel is adapted to receive an orthopedic rod, and the hole in the saddle member is adapted to receive the anchoring member. The saddle member and the anchoring member can be coupled so as to allow multi-axial movement of the members.

Abstract: A handle for use with cookware that has a base and a lid defining a cooking chamber. The handle is pivotally mountable to cookware about a horizontal axis and moves between a lifting position and a stored position. The handle has a cam for raising an edge of the lid when the handle is pivoted towards the stored position. A catch can be provided for positioning and holding the handle relative to the cookware. The catch has an elastically resilient member having a detent for engaging a recess positioned with the handle and is released by force applied to the handle.

Abstract: Retractable cord assembly has a power cord for supplying power to an electrical appliance and a plug top with electrical pins connected to one end of the cord for connection with a wall outlet. The power cord is coiled on a spring-loaded spool within the plug top and is extendable from the plug top. The spring-loaded spool provides a retracting force to retract the power cord back within the plug top.

Abstract: A domestic appliance has a heated heat transfer member located in or on its housing and a temperature sensor for measuring the operating temperature of the transfer member. User inputs are provided for selecting an optimized temperature setting for the transfer member. A temperature controller controls the operating temperature of the heat transfer member in response to signals from the temperature sensor to maintain it at or near the selected temperature setting. The power cord of the appliance has a plug top with electrical pins for connection with a wall outlet. The power cord is coiled on a spring-loaded spool within the plug top and is extendable from the plug top. The spring-loaded spool provides a retracting force to retract the power cord back within the plug top.

Abstract: In one embodiment of the invention, an anterior fixation system includes a plate defining a plurality of screw holes, a number of screws and a number of locking assemblies for fixing the screws to the plate. The system includes two bone screws a fixed angle screw and a variable angle screw, that are configured to extend through the same screw openings in the fixation plate. The surgeon can select either the fixed or variable angled screws to be implanted with a single plate and can place either type of screw into any of the screw holes along the plate. The fixation plate according to the invention can include several screw holes in various patterns that provide the surgeon with great flexibility in the placement of bone screws depending upon the spinal anatomy and pathology. The invention further contemplates a locking assembly to lock one or more bone screws within a respective screw hole. In one embodiment, the locking assembly includes a washer that is held to the plate by a staked locking screw.

Abstract: A handle for use with cookware that has a base and a lid defining a cooking chamber. The handle is pivotally mountable to cookware about a horizontal axis and moves between a lifting position and a stored position. The handle has a cam for raising an edge of the lid when the handle is pivoted towards the stored position. A catch can be provided for positioning and holding the handle relative to the cookware. The catch has an elastically resilient member having a detent for engaging a recess positioned with the handle and is released by force applied to the handle.

Abstract: The present invention is directed to a plating system for anterior fixation of the spine that utilizes a fixation plate. The plating system stabilizes the spine and promotes fusion and incorporation of a graft in a portion of the spinal column. The plating system includes a fixation plate and bone screws that extend through holes in the plate to rigidly secure the plate to vertebrae. The plating system also includes a retainer assembly that prevents screw back out. Methods and instruments relating to the plating system are also described.

Abstract: The present invention provides compositions and methods for gene identification, as well as drug discovery and assessment. In particular, the present invention provides components of an E3 complex involved in ubiquitination of cell cycle regulators and other proteins, as well as members of a class of proteins that directly function in recognition of ubiquitination targets. The present invention also provides sequences of multiple F-box proteins.

Abstract: In one embodiment of the invention, an anterior fixation system includes a plate defining a plurality of screw holes, a number of screws and a number of locking assemblies for fixing the screws to the plate. The system includes two bone screws a fixed angle screw and a variable angle screw, that are configured to extend through the same screw openings in the fixation plate. The surgeon can select either the fixed or variable angled screws to be implanted with a single plate and can place either type of screw into any of the screw holes along the plate. The fixation plate according to the invention can include several screw holes in various patterns that provide the surgeon with great flexibility in the placement of bone screws depending upon the spinal anatomy and pathology. The invention further contemplates a locking assembly to lock one or more bone screws within a respective screw hole. In one embodiment, the locking assembly includes a washer that is held to the plate by a staked locking screw.

Abstract: In one embodiment of the invention, an anterior fixation system includes a plate defining a plurality of screw holes, a number of screws and a number of locking assemblies for fixing the screws to the plate. The system includes two bone screws, a fixed angle screw and a variable angle screw, that are configured to extend through the same screw openings in the fixation plate. The surgeon can select either the fixed or variable angled screws to be implanted with a single plate and can place either type of screw into any of the screw holes along the plate. The fixation plate according to the invention can include several screw holes in various patterns that provide the surgeon with great flexibility in the placement of bone screws depending upon the spinal anatomy and pathology. The invention further contemplates a locking assembly to lock one or more bone screws within a respective screw hole. In one embodiment, the locking assembly includes a washer that is held to the plate by a staked locking screw.

Abstract: The present invention provides compositions and methods for gene identification, as well as drug discovery and assessment. In particular, the present invention provides components of an E3 complex involved in ubiquitination of cell cycle regulators and other proteins, as well as members of a class of proteins that directly function in recognition of ubiquitination targets. The present invention also provides sequences of multiple F-box proteins.

Abstract: The present invention is directed to a system for anterior fixation of the spine that utilizes an elongated fixation plate. The plating system stabilizes the spine and promotes fusion and incorporation of a graft or implant in a portion of the spinal column. In one aspect of the invention, the fixation plate has a first end with a pair of holes. Bone screws extend through the holes to rigidly secure the plate to a first vertebra. The second end of the plate is provided with a pair of slots through which bone screws extend for engagement with a second vertebra. The screws extending through the slots are translatable in the slot to maintain compression of the spinal column portion. The plating system includes a retainer assembly that prevents screw back out. Methods and instruments relating to the plating system are also described.