Patents by Inventor Jeffrey Wu

Jeffrey Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
    Patent number: 12583862
    Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: September 28, 2023
    Date of Patent: March 24, 2026
    Assignee: NURIX THERAPEUTICS, INC.
    Inventors: Daniel W. Robbins, Arthur T. Sands, Joel Mcintosh, Jeffrey Mihalic, Jeffrey Wu, Daisuke Kato, Dahlia Weiss, Ge Peng
  • Substituted pyrrolo[1,2-b]pyridazines as bifunctional degraders of interleukin-1 receptor-associated kinases
    Patent number: 12570662
    Abstract: The present disclosure provides bifunctional compounds represented by Formula (I) as IRAK4 degraders via ubiquitin proteasome pathway, and methods for treating diseases modulated by IRAK4:
    Type: Grant
    Filed: April 1, 2024
    Date of Patent: March 10, 2026
    Assignees: Nurix Therapeutics, Inc., Gilead Sciences, Inc.
    Inventors: Wylie Palmer, Jeffrey Wu, John Lee, Kerem Ozboya, Tim Kane
  • BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY
    Publication number: 20260035378
    Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: October 8, 2025
    Publication date: February 5, 2026
    Inventors: Daniel W. ROBBINS, Arthur T. SANDS, Joel MCINTOSH, Jeffrey MIHALIC, Jeffrey WU, Daisuke KATO, Dahlia WEISS, Ge PENG
  • Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof
    Patent number: 12528814
    Abstract: The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: January 20, 2026
    Assignees: Nurix Therapeutics, Inc., Gilead Sciences, Inc.
    Inventors: Wylie Solang Palmer, Jeffrey Wu, Sheila Zipfel, Kerem Ozboya, Dahlia Weiss
  • QUANTUM-DOT OPTICAL FILM AND THE METHOD TO MAKE THE SAME
    Publication number: 20250360700
    Abstract: A quantum-dot optical film comprising: a binder, wherein a plurality of quantum dots, a plurality of diffusing particles, and a plurality of clay fragments are dispersed in the binder, wherein each of the clay fragments is capable of being water-resistant and oxygen-resistant.
    Type: Application
    Filed: August 3, 2025
    Publication date: November 27, 2025
    Inventors: Chia-Yeh Miu, Ge-Wei Lin, Chia-Jung Chiang, Lung-Pin Hsin, Ying-Yi Lu, Jeffrey Wu, Hui-Yong Chen
  • QUANTUM-DOT OPTICAL FILM AND THE METHOD TO MAKE THE SAME
    Publication number: 20250346804
    Abstract: A quantum-dot optical film comprises: a binder, wherein a plurality of quantum dots, and a plurality of clay fragments are dispersed in the binder, wherein each of the clay fragments is capable of being water-resistant and oxygen-resistant.
    Type: Application
    Filed: July 21, 2025
    Publication date: November 13, 2025
    Inventors: Chia-Yeh Miu, Ge-Wei Lin, Chia-Jung Chiang, Lung-Pin Hsin, Ying-Yi Lu, Jeffrey Wu, Hui-Yong Chen
  • Composite quantum dot optical film comprising first and second optical prism films
    Patent number: 12411271
    Abstract: The present invention discloses a quantum-dot composite film comprising: a quantum-dot prism film, comprising a quantum-dot layer and a first plurality of prisms disposed over the quantum-dot layer, wherein a first optical prism film and a second optical prism film are disposed over the quantum-dot prism film for increasing the brightness level of the quantum-dot prism film.
    Type: Grant
    Filed: November 29, 2021
    Date of Patent: September 9, 2025
    Assignee: UBRIGHT OPTRONICS CORPORATION
    Inventors: Chia-Yeh Miu, Yu-Mei Juan, Chia-Jung Chiang, Ge-Wei Lin, Ying-Yi Lu, Hui-Yong Chen, Lung-Pin Hsin, Jeffrey Wu
  • Quantum-dot optical film and the method to make the same
    Patent number: 12365831
    Abstract: A quantum-dot optical film comprises: a binder, wherein a plurality of quantum dots, and a plurality of clay fragments are dispersed in the binder, wherein each of the clay fragments is capable of being water-resistant and oxygen-resistant.
    Type: Grant
    Filed: April 22, 2022
    Date of Patent: July 22, 2025
    Assignee: UBRIGHT OPTRONICS CORPORATION
    Inventors: Chia-Yeh Miu, Ge-Wei Lin, Chia-Jung Chiang, Lung-Pin Hsin, Ying-Yi Lu, Jeffrey Wu, Hui-Yong Chen
  • SUBSTITUTED PYRROLO[1,2-b]PYRIDAZINES AS BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES
    Publication number: 20240417402
    Abstract: The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.
    Type: Application
    Filed: April 1, 2024
    Publication date: December 19, 2024
    Inventors: Wylie Palmer, Jeffrey Wu, John Lee, Kerem Ozboya, Tim Kane
  • HEART VALVE FRAME DESIGN WITH NON-UNIFORM STRUTS
    Publication number: 20240315838
    Abstract: An implantable prosthetic valve assembly, according to one embodiment, comprises a frame assembly including a plurality of struts and a prosthetic valve secured inside the frame assembly by one or more sutures. At least one of the plurality of spaced struts contains a recess that accepts a portion of the one or more sutures.
    Type: Application
    Filed: May 31, 2024
    Publication date: September 26, 2024
    Inventors: Yong Gao, Pu Zhou, Tianwen Zhao, Jeffrey Wu
  • COMPOSITE QUANTUM-DOT OPTICAL FILM
    Publication number: 20240244943
    Abstract: A composite quantum-dot optical film comprises a quantum-dot layer and a substrate, wherein the substrate comprises a unitary body formed by a first material, wherein a plurality of particles are disposed in the unitary body that encapsulates an outer surface of a first particle with said outer surface of the first particle being located above the top surface of the unitary body, wherein the substrate is disposed over the quantum-dot layer.
    Type: Application
    Filed: January 18, 2024
    Publication date: July 18, 2024
    Inventors: Chia-Yeh Miu, Chia-Jung Chiang, TING YING LIU, Lung-Pin Hsin, Jeffrey Wu, Hui-Yong Chen
  • Heart valve frame design with non-uniform struts
    Patent number: 12023241
    Abstract: An implantable prosthetic valve assembly, according to one embodiment, comprises a frame assembly including a plurality of struts and a prosthetic valve secured inside the frame assembly by sutures. At least one of the plurality of spaced struts contains at least one hole that passes from one side of the at least one strut to another side of the at least one strut and a recess disposed around the hole.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: July 2, 2024
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Yong Gao, Pu Zhou, Tianwen Zhao, Jeffrey Wu
  • Quantum-dot composite film and the method to make the same
    Patent number: 12013554
    Abstract: The present invention discloses a quantum-dot composite optical film comprising: a plurality of quantum dots dispersed in the optical film, wherein the plurality of quantum dots are capable of being water-resistant and oxygen-resistant; and a plurality of prisms, disposed over the quantum-dot layer.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: June 18, 2024
    Assignee: UBRIGHT OPTRONICS CORPORATION
    Inventors: Chia-Yeh Miu, Chia-Jung Chiang, Chien-Chih Lai, Lung-Pin Hsin, Yi-Long Tyan, Jeffrey Wu, Hui-Yong Chen
  • Substituted pyrrolo[1,2-b]pyridazines as bifunctional degraders of interleukin-1 receptor-associated kinases
    Patent number: 11976071
    Abstract: The present disclosure provides bifunctional compounds of Formula (I), and pharmaceutically acceptable salts, isotopic forms, isolated stereoisomers, or mixtures of stereoisomers thereof, as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.
    Type: Grant
    Filed: August 18, 2022
    Date of Patent: May 7, 2024
    Assignee: Gilead Sciences, Inc.
    Inventors: Wylie Palmer, Jeffrey Wu, John Lee, Kerem Ozboya, Tim Kane
  • BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY
    Publication number: 20240124475
    Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: September 28, 2023
    Publication date: April 18, 2024
    Inventors: Daniel W. Robbins, Arthur T. SANDS, Joel MCINTOSH, Jeffrey MIHALIC, Jeffrey WU, Daisuke KATO, Dahlia WEISS, Ge PENG
  • Quantum-dot film and the method to make the same
    Patent number: 11885987
    Abstract: The present invention discloses a quantum-dot film, wherein the quantum-dot film comprises a binder and a plurality of quantum dots dispersed in the binder, wherein the plurality of quantum dots are capable of being water-resistant and oxygen-resistant.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: January 30, 2024
    Assignee: UBRIGHT OPTRONICS CORPORATION
    Inventors: Chia-Yeh Miu, Ge-Wei Lin, Chia-Jung Chiang, Chien-Chih Lai, Lung-Pin Hsin, Yi-Long Tyan, Jeffrey Wu, Hui-Yong Chen, Ying-Yi Lu
  • Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
    Patent number: 11866442
    Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: July 28, 2022
    Date of Patent: January 9, 2024
    Assignee: NURIX THERAPEUTICS, INC.
    Inventors: Daniel W. Robbins, Arthur T. Sands, Joel McIntosh, Jeffrey Mihalic, Jeffrey Wu, Daisuke Kato, Dahlia Weiss, Ge Peng
  • Morpholino oligonucleotides useful in cancer treatment
    Patent number: 11679121
    Abstract: Disclosed are morpholino oligonucleotides that can be used to silence expression of MGMT, pharmaceutical compositions that include said morpholino oligonucleotides, and methods of using said morpholino oligonucleotides in the treatment of cancer, particularly methods that involve the use of radiation to deliver said morpholino oligonucleotides.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: June 20, 2023
    Assignees: United States Government As Represented By The Department of Veterans Affairs, Oregon Health & Science University
    Inventors: Prakash Ambady, Jeffrey Wu, Edward Neuwelt
  • BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF
    Publication number: 20230142629
    Abstract: The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.
    Type: Application
    Filed: February 19, 2021
    Publication date: May 11, 2023
    Inventors: Wylie Solang PALMER, Jeffrey WU, Sheila ZIPFEL, Kerem OZBOYA, Dahlia WEISS
  • BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF
    Publication number: 20230120619
    Abstract: The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.
    Type: Application
    Filed: August 18, 2022
    Publication date: April 20, 2023
    Inventors: Wylie Palmer, Jeffrey Wu, John Lee, Kerem Ozboya, Tim Kane