Abstract: The present application provides tricyclic compounds that modulate the activity of the PI3K?, which are useful in the treatment of various diseases, including cancer.

Abstract: Disclosed are compounds of Formula I, shown below, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Abstract: The present disclosure provides compounds, compositions, and methods useful for inhibiting PI3Ka, and/or treating a disease, disorder, or condition associated with PI3Ka, and/or treating cancer.

Abstract: Described herein are light-activatable, sustained-exposure compositions for the treatment and monitoring of diseases along with methods of making and using the same, wherein the compositions comprise a solvent, a cellulosic polymer, a photosensitizer, and optionally additional therapeutic agents. In some embodiments, an additional therapeutic agent is included. The compositions can be administered to a target in need, such as a tumor or lesion, and activated with a light source to induce necrosis or apoptosis and to track the distribution of the composition at the target site. Beneficially the compositions provide synergistic ablation and photodynamic efficacy.

Abstract: The present disclosure provides compounds, compositions, and methods useful for inhibiting PARP1, and/or treating a disease, disorder, or condition associated with PARP1, and/or treating cancer.

Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Abstract: A foot abduction brace is disclosed herein. The foot abduction brace can include a crossbar having a planar bottom end. The foot abduction brace can also include a first end disposed on one side of the crossbar. The foot abduction brace can further include a first locking hub removably coupled to the first end in a first position of a plurality of positions, where the first locking hub is disposed in the first keyhole and includes a first coupling feature disposed at a top end of the first locking hub. The foot abduction brace can also include a first footplate having a first complementary coupling feature that removably couples to the first coupling feature of the first locking hub. The foot abduction brace can further include a first foot restraint mechanically coupled to the first footplate.

Abstract: Described herein is a porous copolymer membrane composed of poly(styrene sulfonate)-block-polyethylene-block-poly(styrenesulfonate) for use in the absorption of doxorubicin, and a chemofiltration catheter incorporating the membrane for use in transarterial chemoembolization.

Abstract: A laparoscope comprises an elongated insertion tube having an open distal end. Optical means are provided for conducting an optical image of a target. The optical means includes an objective lens. A transparent sphere houses the lens. The sphere is rotatably disposed in the distal end of the tube such that a portion of the sphere protrudes from the tube. A ring-shaped wiper is fixed to the distal end of the tube for circumferentially engaging the sphere. Means are disposed in the tube for rotating the sphere, wherein the wiper removes debris and fluids from the surface of the sphere as the sphere rotates.

Abstract: A method for establishing redundant connections for a virtual machine, which comprises: obtaining a plurality of storage nodes storing a same virtual machine image of the virtual machine; determining at least two storage nodes from the plurality of storage nodes, so that connections between a compute node provisioning the virtual machine and each of the at least two storage nodes have minimum correlation; and establishing connections between the compute node and the at least two storage nodes respectively. The present invention further discloses the corresponding apparatus.

Abstract: Described herein is a copolymer membrane and a chemofiltration catheter incorporating the membrane for use in transarterial chemoembolization.

Abstract: A method for establishing redundant connections for a virtual machine, which comprises: obtaining a plurality of storage nodes storing a same virtual machine image of the virtual machine; determining at least two storage nodes from the plurality of storage nodes, so that connections between a compute node provisioning the virtual machine and each of the at least two storage nodes have minimum correlation; and establishing connections between the compute node and the at least two storage nodes respectively. The present invention further discloses the corresponding apparatus.

Abstract: A laparoscope comprises an elongated insertion tube having an open distal end. Optical means are provided for conducting an optical image of a target. The optical means includes an objective lens. A transparent sphere houses the lens. The sphere is rotatably disposed in the distal end of the tube such that a portion of the sphere protrudes from the tube. A ring-shaped wiper is fixed to the distal end of the tube for circumferentially engaging the sphere. Means are disposed in the tube for rotating the sphere, wherein the wiper removes debris and fluids from the surface of the sphere as the sphere rotates.

Abstract: A foot abduction brace is disclosed herein. The foot abduction brace can include a crossbar having a planar bottom end. The foot abduction brace can also include a first end disposed on one side of the crossbar. The foot abduction brace can further include a first locking hub removably coupled to the first end in a first position of a plurality of positions, where the first locking hub is disposed in the first keyhole and includes a first coupling feature disposed at a top end of the first locking hub. The foot abduction brace can also include a first footplate having a first complementary coupling feature that removably couples to the first coupling feature of the first locking hub. The foot abduction brace can further include a first foot restraint mechanically coupled to the first footplate.

Abstract: A metal and oxygen material such as a transparent electrically conductive oxide material is electro deposited onto a substrate in a solution deposition process. Process parameters are controlled so as to result in the deposition of a high quality layer of material which is suitable for use in a back reflector structure of a high efficiency photovoltaic device The deposition may be carried out in conjunction with a masking member which operates to restrict the deposition of the metal and oxygen material to specific portions of the substrate. In particular instances the deposition may be implemented in a continuous, roll-to-roll process. Further disclosed are semiconductor devices and components of semiconductor devices made by the present process, as well as apparatus for carrying out the process.

Abstract: A metal and oxygen material such as a transparent electrically conductive oxide material is electro deposited onto a substrate in a solution deposition process. Process parameters are controlled so as to result in the deposition of a high quality layer of material which is suitable for use in a back reflector structure of a high efficiency photovoltaic device. The deposition may be carried out in conjunction with a masking member which operates to restrict the deposition of the metal and oxygen material to specific portions of the substrate. In particular instances the deposition may be implemented in a continuous, roll-to-roll process. Further disclosed are semiconductor devices and components of semiconductor devices made by the present process, as well as apparatus for carrying out the process.

Abstract: A metal and oxygen material such as a transparent electrically conductive oxide material is electro deposited onto a substrate in a solution deposition process. Process parameters are controlled so as to result in the deposition of a high quality layer of material which is suitable for use in a back reflector structure of a high efficiency photovoltaic device. The deposition may be carried out in conjunction with a masking member which operates to restrict the deposition of the metal and oxygen material to specific portions of the substrate. In particular instances the deposition may be implemented in a continuous, roll-to-roll process. Further disclosed are semiconductor devices and components of semiconductor devices made by the present process, as well as apparatus for carrying out the process.

Abstract: A metal and oxygen material such as a transparent electrically conductive oxide material is electro deposited onto a substrate in a solution deposition process. Process parameters are controlled so as to result in the deposition of a high quality layer of material which is suitable for use in a back reflector structure of a high efficiency photovoltaic device. The deposition may be carried out in conjunction with a masking member which operates to restrict the deposition of the metal and oxygen material to specific portions of the substrate. In particular instances the deposition may be implemented in a continuous, roll-to-roll process. Further disclosed are semiconductor devices and components of semiconductor devices made by the present process, as well as apparatus for carrying out the process.