Abstract: In one aspect, the present disclosure provides for novel compositions of matter comprising multi domain peptide (MDP) hydrogels and cyclic dinucleotides (CDNs). Also disclosed are method of using such compositions in the treatment of cancer, including in particular the treatment of head and neck cancers, such as those resistant to CDN therapy.

Abstract: The present disclosure provides methods, systems, and non-transitory computer-readable media for collecting, storing, assessing, and managing human readable diagnostic test results (e.g., results from Point-of-Care testing and self-testing). The present disclosure provides methods, systems, and non-transitory computer-readable media for collecting, storing, assessing, and managing images and image results. The systems and methods facilitate unbiased verification and notification of test and image results.

Abstract: In some embodiments, a system and a computer-implemented method for role-based collaborative design based on manufacturing constraints are disclosed.

Abstract: Gaze tracking data representing a user's gaze is analyzed to determine one or more regions of interest. One or more gaze tracking parameters are determined from the gaze tracking data. Adjusted foveation data is determined representing an adjusted size and/or shape of one or more regions of interest in one or more images to be subsequently presented to the user based on the one or more gaze tracking parameters. The compression of the one or more transmitted images is adjusted so that fewer bits are needed to transmit data for portions of an image outside the one or more regions of interest than for portions of the image within the one or more regions of interest. Adjusting compression includes eliminating the region(s) of interest from images that are presented to the user during the saccade or blink.

Abstract: In some embodiments, a computer-implemented method comprises: receiving an indication of a particular design style; determining, based on the indication, functional product groups that comprise a plurality of custom products having indicia of the particular design style; initiating a collaboration session between a user and one or more collaborators to allow selecting one or more particular custom products; in response to receiving a selection of the particular custom products, generating a group of customized products comprising the one or more particular custom products, each particular customized product associated with a product type of a plurality of product types, each product type of the plurality of product types associated with a manufacturing constraint of multiple manufacturing constraints, each particular customized product having shared content that all of the one or more particular custom products share; obtaining manufacturing methods for manufacturing the customized particular products; and pr

Abstract: Systems and methods are provided for configuring automatic playback settings on a media playback device. A graphical user interface displays automatic playback settings and receives selections of customized settings for automatic playback. The settings can include context granularity for automatic playback, limiting autoplay to when the media playback device is connected to a wireless network, and activating an audible notification when automatic playback of media content is beginning. An initial queue of media content is selected for playback on the media playback device. The system ascertains whether autoplay is enabled for a particular situation. If autoplay is enabled, the system automatically generates a queue of media that is related to the initial queue and initiates playback on the media playback device after the initial queue concludes.

Abstract: Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a Superoxide Dismutase 1 (SOD1) gene. The SOD1 RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of an SOD1 gene. Pharmaceutical compositions that include one or more SOD1 RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described SOD1 RNAi agents to central nervous system (CNS) tissue, in vivo, provides for inhibition of SOD1 gene expression and a reduction in SOD1 activity, which can provide a therapeutic benefit to subjects, including human subjects, for the treatment of various diseases including amyotrophic lateral sclerosis (ALS.).

Abstract: In some embodiments, a computer-implemented method comprises: generating a group of customized products comprising one or more customized products, each customized product associated with a product type of a plurality of product types, each product type of the plurality of product types associated with a manufacturing constraint of multiple manufacturing constraints, each customized product having shared content that all customized products share; for a customized product from the group: obtaining a manufacturing method for manufacturing the customized product, determining a product type of the customized product and a manufacturing constraint associated with the product type, and determining physical constraints for manufacturing the customized product; generating transformed shared content to satisfy the physical constraints for manufacturing the customized product; in response to receiving a user input: automatically generating a GUI based on, at least in part, the shared content; using the GUI, generating

Abstract: A returned stair tread assembly comprises a tread plate, a front nosing and a return nosing fitted flush against each other to form an exposed joint between the front and return nosings, and a device for securing the return nosing to the front nosing and the stair tread plate. The tread plate has a side tongue. The front nosing has a front nosing tongue spaced from a forward end of a side edge surface of the front nosing. The return nosing receiving the front nosing tongue of the front nosing and the side tongue of the stair tread plate therein. A front end of the side groove is spaced from a forward end of the return nosing. The front nosing tongue and the side tongue are disposed in the side groove and configured to slidably connect the stair tread plate and the return nosing.

Abstract: A returned stair tread assembly comprises a tread plate, a front nosing and a return nosing fitted flush against each other to form an exposed joint between the front and return nosings, and a device for securing the return nosing to the front nosing and the stair tread plate. The tread plate has a side tongue. The front nosing has a front nosing tongue spaced from a forward end of a side edge surface of the front nosing. The return nosing receiving the front nosing tongue of the front nosing and the side tongue of the stair tread plate therein. A front end of the side groove is spaced from a forward end of the return nosing. The front nosing tongue and the side tongue are disposed in the side groove and configured to slidably connect the stair tread plate and the return nosing.

Abstract: An architecture for fault-tolerant universal quantum computation is suited for matter qubits, such as donor qubits in silicon, coupled by a network of photonic interconnects. The basic operational building blocks are local measurements and unitaries, plus an entangling measurement of non-local Pauli operators. 3D graph states created by applying deterministic entangling measurements to pairs of qubits in knitting and fusion processes to yield resource states for one way computing. The deterministic entangling measurements are facilitated by configuring the network with active switches to allow single photons to interact with pairs of matter qubits.

Abstract: An airbag module for a roof opening of a vehicle having an expandable safety device configured to be deployed after a dynamic vehicle event, such as a vehicle rollover. The airbag module includes a mechanism and an inflator in order to deploy the expandable safety device across the roof opening of the vehicle.

Abstract: An electronic system provides various features and functionality for managing resources. An alert may be sent when a mobile device crosses a geo-fence. The alert may describe how much of the resource is available for the types of transaction that are likely to occur within the geo-fence. The alert may request or confirm the allocation of the transaction to a resource pool or suggest alternative transactions.

Abstract: An anesthetic administration device comprising an infusion device, which is in fluid connection with a regional anesthetic needle by means of a feed tube. The infusion device comprises one or more anesthetic flow devices capable of triggering forward flow, and optionally backward flow, of the local anesthetic through the regional anesthetic needle. Forward, and optionally backward flow, of the local anesthetic through the regional anesthetic needle is controlled by a controller that comprises one or more actuator switches. The one or more actuator switches are positioned on the device 1 such that they may be operated by hand.

Abstract: Described herein are constructs, compositions and methods for precise in vivo imaging of the structures and dynamics of protein-based scaffolds with and without their designated cargos.

Abstract: A safety apparatus is provided for use in a procedure comprising at least first and second devices, wherein the first device and second device are for use in a medical procedure. The apparatus includes a disabling mechanism that is adapted to releasably retain and thereby prevent use of the said second device until release by a release procedure using the first device. A method is provided of carrying out a procedure comprising the steps of using the first device, applying the first device to a disabling mechanism to release the second device, and using the second device.

Abstract: Aspects of the disclosure relate to using cognitive automation for customized interface generation. A computing platform may receive user interaction information. Based on the user interaction information, the computing platform may identify a user intent. Using a cognitive automation model, the computing platform may identify a final graphical user interface corresponding to the user intent, where the final graphical user interface may be a last graphical user interface, of a sequence of graphical user interfaces, that was displayed at a user device to satisfy the user intent. The computing platform may send commands directing an enterprise source host system to cause display of the final graphical user interface without causing display of preceding graphical user interfaces of the sequence of graphical user interfaces. The computing platform may receive a feedback message indicating a level of satisfaction with the final graphical user interface and may update the cognitive automation model accordingly.

Abstract: A safety apparatus for use in a procedure comprises at least first and second devices, wherein the first device and second device are for use in a medical procedure, the apparatus comprising a disabling mechanism that is adapted to releasably retain and thereby prevent use of the said second device until release by a release procedure using the first device. A method of carrying out a procedure comprises the steps of using the first device, applying the first device to a disabling mechanism to release the second device, and using the second device.