Abstract: A high-frequency generator connects an electrosurgical instrument, including an electrical output connection point for an electrosurgical instrument, a power supply, which is at least indirectly connected to the output connection point, and a power controller for controlling the electrical output power output via the output connection point. The power controller is designed to begin the output of an electrical output power when an output energy balance amount is greater than an output energy limit value and to end the output of the electrical output power when the output energy balance amount falls below a minimum value.

Abstract: An electrosurgical generator supplies, during operation, a high-frequency alternating current to an electrosurgical instrument for plasma cutting of body tissue. The electrosurgical generator has outputs for connecting an electrosurgical instrument to supply an electrosurgical instrument connected to the outputs with a high-frequency alternating current, and for determining the impedance of a load connected to the outputs. The electrosurgical generator features impedance and voltage measuring units as well as an output voltage control unit. The output voltage control unit is designed to control the AC output voltage depending on a maximum output voltage value that is set during operation depending on an output value of the impedance measuring unit and/or depending on an output value of the voltage measuring unit, such that the maximum output voltage value predefines a lower AC output voltage during a vaporization phase than during an ignition phase occurring subsequently to the vaporization phase.

Abstract: Electrosurgical generator and method for outputting a high-frequency alternating voltage to an electrosurgical instrument, including an inverter that generates a high-frequency alternating voltage having variable frequency and amplitude which is fed to an output socket for the electrosurgical instrument. Ahe inverter is a multi-level inverter controlled by a reference signal defining shape of the generated HF alternating voltage, the reference signal being defined by a datagram including a finite series of sequenced amplitude and frequency data vectors for a defined number of periods. By such datagrams including descriptive data for the desired HF sinusoidal curve, data amount and bandwidth required can be reduced. Thereby a variety of modes can be described using a minimum of data which can be as low as just a few dozen bytes long. This allows for efficient control even of complex modes.

Abstract: Electrosurgical generator for providing a high-frequency alternating voltage to an electrosurgical instrument, including a control unit and an inverter for high voltage that generates a high-frequency alternating voltage fed to an output socket for the instrument. A detection unit is provided that includes a capacitive detector configured for detecting a capacitance of a plugged-in cable of the instrument. Thereby a parasitic capacitance induced by the instrument's cable can be detected. The capacitance is however low picofarad range and difficult to detect, further complicated by the requirement of galvanic separation for patient safety. However, the invention realized that just a qualitative detection is sufficient to determine whether the instrument's cable is being plugged in. The invention provides simple and efficient measurement circuit for such detection. Thereby, a safe and cost-effective plugging-in detection is realized.

Abstract: A surgical generator configured to output a high-frequency alternating voltage to a surgical ultrasound instrument. An oscillator generates a driving oscillation for an inverter generating high-frequency voltage being for the surgical instrument. A matching-coil emulation device includes a correction device acting on the driving oscillation. The correction device includes a mixing unit and a feedback circuit, modifying the driving oscillation supplied to the inverter. An estimator calculates a virtual current which would flow in the emulated matching-coil if it were present, based on this and a measured output voltage an artificial phase shift is determined for steering of the oscillator. Thereby, the transfer function is reshaped mimicking that of a physical matching coil. Accordingly, a bulky matching coil that must be precisely tuned to the ultrasound instrument and restricts use of newer and different ultrasound instruments is no longer needed.

Abstract: An electrosurgical generator which outputs high-frequency AC voltage for an electrosurgical instrument includes a leakage current detecting device for the connected electrosurgical instrument. The leakage current detecting device is embodied as a voltage measuring device, the inputs of which are connected in each case via a capacitive coupling to an active and a neutral line of the output line and which has a bipolar voltage divider having a predetermined fixed ratio. An asymmetry detector connected via a capacitive coupling compares upper and lower voltage at the voltage divider, and outputs a fault signal for leakage current in the case of deviation of the ratio of upper to lower voltage from the predetermined fixed ratio.

Abstract: An electrosurgical generator with a high-voltage power supply that supplies a DC output voltage receives the DC output voltage of the high-voltage power supply and generates a high-frequency AC output voltage. When generator is operating, a control unit receives signals from an AC output voltage measuring unit and current measuring unit. The control unit limits an increase of DC output voltage of the high-voltage power supply as soon one predefined maximum value is reached or exceeded. When the generator is operating, the control unit configured to receive signals from a DC output voltage measuring unit that represent a respective current value of the DC output voltage, and to compare a respective current value of DC output voltage with a predefined minimum value for DC output voltage, and to cause the DC output voltage of the high-voltage power supply to increase as soon as it falls below the predefined minimum value.

Abstract: An electrosurgical generator for an electrosurgical instrument includes a DC voltage supply and a high-voltage inverter that generates a high-frequency AC voltage having a variable voltage and frequency that is output at an output for the connection of the electrosurgical instrument. The inverter is configured as a multilevel inverter and includes a plurality of inverter cells connected in a cascaded manner that are driven by a control device. Thanks to the cascading, switching losses incurred in the power semiconductors are reduced, both in terms of value (through the divided and thus lower voltage) and in terms of frequency (through the reduced switching frequency).

Abstract: An electrosurgical generator for an electrosurgical instrument includes DC voltage supply and high-voltage inverter that generates high-frequency AC voltage having variable voltage and frequency. Inverter is multilevel inverter controlled by reference signal and having at least two groups of series-connected inverter cells, wherein each group is supplied with different DC voltage and wherein the voltages output by the two groups are summed to be output at output. Group supplied with higher voltage enables fast and large voltage changes with its inverter cells, while inverter cells of other group supplied with lower voltage allow fine setting with high change speed. Dynamic range is improved both from temporal viewpoint and in terms of increased voltage span. The number of HVC cells to be switched may furthermore be varied by way of modulator, wherein further number of LVC cells are switched in an opposing manner for compensation purposes. Switching losses may be reduced.

Abstract: An electrosurgical generator for generating a high-frequency AC voltage for an electrosurgical instrument, having a high-voltage inverter that generates and outputs a high-frequency AC voltage. A filter having a parallel capacitor is on an output line. A measuring sensor circuit having a current divider, which has a capacitive coupling to a series-connected shunt as bypass with respect to the parallel capacitor, and having a voltage detection circuit connected to the shunt. The shunt has a considerably lower impedance than the capacitive coupling. This gives rise to a proportional ratio between the current flowing through the parallel capacitor on the output line of the electrosurgical generator and the current through the shunt. This current is converted into a voltage, which is detected. The current at the output of the inverter is determined quickly and accurately thanks to the proportional relationship. This may be used for feedback and improved monitoring and regulation.

Abstract: An electrosurgical generator comprising two HF generator units, two output transformers, and at least four output terminals for connecting electrosurgical instruments. Together with the associated output transformer and corresponding output terminals, each HF generator unit forms an HF generator module.

Abstract: A hydrogel particle that has an average cross-sectional diameter in the range from 1 micrometer (?m) to 1000 ?m, wherein the particle includes a first polymer network with an average mesh size that allows diffusion of a molecule with an hydrodynamic radius of 1000 nanometer (nm) or less into the first polymer network and which particle includes one or more binding molecules that are immobilized by the polymer network. The hydrogel particle preferably has wherein the first polymer network has an average mesh size that prevents diffusion of a molecule with an average hydrodynamic radius of more than 1000 nm to diffuse into the first polymer network, preferably the mesh size prevents diffusion of a molecule with an average hydrodynamic radius of more than 100 nm, and preferably more than 5 nm. Methods for reducing the bioavailability of one or more soluble biological molecules in a biological system by using the described hydrogel particle.

Abstract: An electrosurgical generator for providing different high-frequency alternating voltages/high-frequency alternating currents includes at least two outputs to which an electrosurgical instrument is or can be connected, at least one high-frequency voltage source, and at least two output transformers connected on the primary side to the high-frequency voltage source and on the secondary side to the outputs for an electrosurgical instrument, wherein both the primary windings of the output transformers can be interconnected via switches and the secondary windings of the output transformers can be interconnected via switches.

Abstract: An electrosurgical generator includes a power supply unit which, when operating, supplies a direct voltage circuit, and a high-voltage inverter supplied from it that generates a high-frequency alternating voltage that is applied to outputs for connection of the electrosurgical instrument. The inverter includes a clock-driven power switch and a zero-crossing detector that recognizes zero crossings of the oscillation generated by the inverter. A signal for the generated alternating voltage is applied to the zero-crossing detector via a voltage divider which is a capacitive voltage divider with at least one capacitor that is resistant to high voltage. Undesirable direct voltage components at the center tap in the presence of changes to the supply voltage can be avoided thereby, since charge reversals as a result of changes to the supply voltage occur on both sides, and their effects thus cancel out.

Abstract: An electrosurgical generator with a high-voltage power supply that supplies a DC output voltage receives the DC output voltage of the high-voltage power supply and generates a high-frequency AC output voltage. When generator is operating, a control unit receives signals from an AC output voltage measuring unit and current measuring unit. The control unit limits an increase of DC output voltage of the high-voltage power supply as soon one predefined maximum value is reached or exceeded. When the generator is operating, the control unit configured to receive signals from a DC output voltage measuring unit that represent a respective current value of the DC output voltage, and to compare a respective current value of DC output voltage with a predefined minimum value for DC output voltage, and to cause the DC output voltage of the high-voltage power supply to increase as soon as it falls below the predefined minimum value.

Abstract: An electrosurgical generator supplies, during operation, a high-frequency alternating current to an electrosurgical instrument for plasma cutting of body tissue. The electrosurgical generator has outputs for connecting an electrosurgical instrument to supply an electrosurgical instrument connected to the outputs with a high-frequency alternating current, and for determining the impedance of a load connected to the outputs. The electrosurgical generator features impedance and voltage measuring units as well as an output voltage control unit. The output voltage control unit is designed to control the AC output voltage depending on a maximum output voltage value that is set during operation depending on an output value of the impedance measuring unit and/or depending on an output value of the voltage measuring unit, such that the maximum output voltage value predefines a lower AC output voltage during a vaporization phase than during an ignition phase occurring subsequently to the vaporization phase.

Abstract: A testing device for an electrosurgical generator, including a first connection port and a second connection port for connecting the testing device to a patient circuit of the electrosurgical generator and including an apparatus for producing a direct voltage between the first connection port and the second connection port. The testing device is characterized in that an HF current path of the patient circuit, running from the first connection port to the second connection port, extends through the testing device and in that the apparatus for producing a direct voltage is fed by an HF current flowing through the HF current path.

Abstract: A high-frequency generator connects an electrosurgical instrument, including an electrical output connection point for an electrosurgical instrument, a power supply, which is at least indirectly connected to the output connection point, and a power controller for controlling the electrical output power output via the output connection point. The power controller is designed to begin the output of an electrical output power when an output energy balance amount is greater than an output energy limit value and to end the output of the electrical output power when the output energy balance amount falls below a minimum value.

Abstract: A hydrogel particle that has an average cross-sectional diameter in the range from 1 micrometer (?m) to 1000 ?m, wherein the particle includes a first polymer network with an average mesh size that allows diffusion of a molecule with an hydrodynamic radius of 1000 nanometer (nm) or less into the first polymer network and which particle includes one or more binding molecules that are immobilized by the polymer network. The hydrogel particle preferably has wherein the first polymer network has an average mesh size that prevents diffusion of a molecule with an average hydrodynamic radius of more than 1000 nm to diffuse into the first polymer network, preferably the mesh size prevents diffusion of a molecule with an average hydrodynamic radius of more than 100 nm, and preferably more than 5 nm. Methods for reducing the bioavailability of one or more soluble biological molecules in a biological system by using the described hydrogel particle.

Abstract: The invention relates to composition comprising a dextran-tyramine conjugate and a conjugate selected from the group consisting of chondroitin sulphate-tyramine, collagen-tyramine, chitosan-tyramine, chitosan-phloretic acid, gelatine-tyramine, heparan sulphate-tyramine, keratin sulphate-tyramine, hyaluronic acid-tyramine and heparin-tyramine.