Patents by Inventor Jen-Chih Hsieh

Jen-Chih Hsieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-aza-2?-deoxycytidine and methods of use thereof for promoting wound healing and regeneration
    Patent number: 11033567
    Abstract: This invention is directed to compositions for promoting wound healing and regeneration and methods of use thereof. In one aspect, methods for promoting wound healing in a subject are provided, the methods comprising: administering a therapeutically effective amount of a DNA methyl transferase inhibitors (DNMT) to the subject. In another aspect, methods for reducing scarring during healing of a skin wound are provided, the methods comprising: administering a therapeutically effective amount of a DNMT inhibitor.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: June 15, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: George Cotsarelis, Jen-Chih Hsieh, Ying Zheng
  • SINGLE NUCLEOTIDE POLYMORPHIC ALLELES OF HUMAN DP-2 GENE FOR DETECTION OF SUSCEPTIBILITY TO HAIR GROWTH INHIBITION BY PGD2
    Publication number: 20200078351
    Abstract: DP-2 antagonists reversed PGD2-mediated human hair growth inhibition in a dose-dependent manner in vitro by reducing PGD2-triggered apoptosis and maintaining proliferation of keratinocytes. Hair follicles from approximately half of the alopecia patients exhibited little susceptibility to PGD2's effect in vitro. SNPs in the human DP-2 gene were identified that are associated with hair growth inhibition by PGD2. These findings underscore the role of DP-2 in regulating hair growth and indicate that DP-2 can be an effective approach in preventing and/or treating androgenetic alopecia in patients sensitive to PGD2. Furthermore, the SNPs identified here can be used to identify patients who will benefit from treatment.
    Type: Application
    Filed: July 28, 2016
    Publication date: March 12, 2020
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: George Cotsarelis, Ying Zheng, Jen-Chih Hsieh
  • 5-AZA-2'- DEOXYCYTIDINE AND METHODS OF USE THEREOF FOR PROMOTING WOUND HEALING AND REGENERATION
    Publication number: 20170209475
    Abstract: This invention is directed to compositions for promoting wound healing and regeneration and methods of use thereof. In one aspect, methods for promoting wound healing in a subject are provided, the methods comprising: administering a therapeutically effective amount of a DNA methyl transferase inhibitors (DNMT) to the subject. In another aspect, methods for reducing scarring during healing of a skin wound are provided, the methods comprising: administering a therapeutically effective amount of a DNMT inhibitor.
    Type: Application
    Filed: July 21, 2015
    Publication date: July 27, 2017
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANNIA
    Inventors: George COTSARELIS, Jen-Chih HSIEH, Ying ZHENG
  • Wnt receptor compositions and methods
    Publication number: 20070269808
    Abstract: Wnt receptor compositions and methods of use are disclosed. In particular, methods using Wnt receptors, such as Dfz2, in screens for compounds which modulate the binding of a Wnt polypeptide to a Wnt receptor.
    Type: Application
    Filed: March 6, 2006
    Publication date: November 22, 2007
    Inventors: Purnima Bhanot, Marcel Brink, Cindy Samos, Yanshu Wang, Jen-Chih Hsieh, Deborah Andrew, Jeremy Nathans, Roeland Nusse
  • Wnt receptor compositions and methods
    Publication number: 20030040051
    Abstract: Wnt receptor compositions and methods of use are disclosed. In particular, methods using Wnt receptors, such as Dfz2, in screens for compounds which modulate the binding of a Wnt polypeptide to a Wnt receptor.
    Type: Application
    Filed: May 21, 2002
    Publication date: February 27, 2003
    Inventors: Purnima Bhanot, Marcel Brink, Cindy H. Samos, Yanshu Wang, Jen-Chih Hsieh, Deborah Andrew, Jeremy Nathans, Roeland Nusse