Abstract: A method for treating cancer in a subject having a tumor in provided. The method includes administering to the subject a plurality of first dosages, each containing a peptide that comprises a sequence containing SEQ ID NO. 1 and is capable of selectively binding to CXC chemokine receptor 4 (CXCR4); and separately administrating to the subject a plurality of second dosages separately contained from the first dosages, the plurality of second dosages containing an immunotherapeutic agent for treating cancer, wherein the immunotherapeutic agent is an antibody that targets at least one of PD-1, PD-L1, TIM-3, LAG-3, B7-1, B7-H3, NKG2A, KIR, BTLA, VISTA/PD-1H, TIGIT, CD96, OX40, CD28, ICOS, HVEM, 41BB, CD40L, CD137, GITR, CD27, CD30, DNAM-1, CD28H and coreceptors thereof.

Abstract: The present disclosure provides a use of pentosan polysulfate sodium (PPS) in the manufacture of a medicament for the prevention of recurrent urinary tract infection (rUTI) in a human subject, comprising a therapeutically effective dosage for oral administration of PPS, wherein the therapeutically effective dosage for oral administration of PPS is 5-1 mg/kg/day.

Abstract: The present disclosure provides a use of pentosan polysulfate sodium (PPS) in the manufacture of a medicament for the prevention of recurrent urinary tract infection (rUTI) in a human subject, comprising a therapeutically effective dosage for oral administration of PPS, wherein the therapeutically effective dosage for oral administration of PPS is 5-1 mg/kg/day.

Abstract: A therapeutic combination for treating cancer in a subject having a tumor in provided. The therapeutic combination includes an immunotherapeutics for treating the cancer, and a peptide having one of SEQ ID NOs. 1-3 and being capable of selectively binding to CXC chemokine receptor 4 (CXCR4). When the peptide of the therapeutic combination binds to CXCR4, an immune microenvironment of the tumor is modulated and/or accessibility of immune cells to the tumor is regulated. A method for treating cancer using the therapeutic combination is also provided.