Patents by Inventor JENG-KUEN TSAI

JENG-KUEN TSAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Supports for cell culture and cell sheet detachment and methods for cell sheet detachment
    Patent number: 9546349
    Abstract: The invention creates a support for cell culture and cell sheet detachment which has a substrate, whose surface is coated with a conjugate having a disulfide bond-containing amino acid as a spacer and a biopolymer enhancing cell attachment, migration or differentation. Unexpectedly, after being seeded on the support, the cells grow to form one or more layers of cell sheets and the cell sheets can be easily detached from the support by adding a reductant to cleave the disulfide bond. Accordingly, the invention provides a simple and non-toxic method for detachment of cell sheets.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: January 17, 2017
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: How Tseng, Jeng-Kuen Tsai, Keng-Liang Ou, Po-Nien Chen
  • SUPPORTS FOR CELL CULTURE AND CELL SHEET DETACHMENT AND METHODS FOR CELL SHEET DETACHMENT
    Publication number: 20120309089
    Abstract: The invention creates a support for cell culture and cell sheet detachment which has a substrate, whose surface is coated with a conjugate having a disulfide bond-containing amino acid as a spacer and a biopolymer enhancing cell attachment, migration or differentation. Unexpectedly, after being seeded on the support, the cells grow to form one or more layers of cell sheets and the cell sheets can be easily detached from the support by adding a reductant to cleave the disulfide bond. Accordingly, the invention provides a simple and non-toxic method for detachment of cell sheets.
    Type: Application
    Filed: May 31, 2011
    Publication date: December 6, 2012
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: HOW TSENG, JENG-KUEN TSAI, KENG-LIANG OU, PO-NIEN CHEN