Abstract: The present invention discloses use of a polyenylpyrrole derivative in preparation of an anti-oral cancer drugs. The polyenylpyrrole derivative synthesized by polyvinylpyrrole, auxarconjugatin A and 12E-isorumbrin inhibits the cell proliferation, migration, tumor sphere formation abilities and xenograft tumorigenicity of oral cancer cells.

Abstract: A compound of formula 1-[3,4-dihydroxy-5-(2-hydroxyethyl)tetrahydrofuran-2-yl]pryimidine-2,4(1H,3H)-dione has inhibitory effects of matrix metalloproteinase-2 (gelatinase A) enzyme and binding of TNF? to TNF?-RI.

Abstract: The present invention discloses a chemically surface-treated plastic slide that is useful for the immobilization of proteins, peptides or small molecules to its surface for the fabrication of biochips. Also disclosed in the present invention is a surface-treated plastic slide made of polystyrene, which is useful for the immobilization of oligonucleotides or polynucleotides to its treated surface for the fabrication of DNA chips.

Abstract: The invention discloses methods of treatment and prevention for TNF&agr;-related disorders and MMP-related disorders and compounds useful in such treatments. In particular, the invention dislcoses pharmaceutical compositions comprising a compound of the general formula: wherein X is a Zn(II) chelating group and selected from the group consisting of (CH2)nOH, (CH2)nNH2, (CH2)nSH, (CH2)mCOOH, (CH2)mCOOR, (CH2)mCONH2, (CH2)m″CONH—OH, (CH2)m″CONH—R, and (CH2)n′O(PO3)m″(m″+1), wherein n=2, 3, 4, or 5, n′=2 or 3, m=1, 2, 3, or 4, m′=1, 2, 3, 4, 5, or 6, m″=1, 2, 3, and R=—Cm′, H2m′+1 or aryl groups, especially 1-[3,4-dihydroxy-5-(2-hydroxyethyl)-tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione, which has an inhibitory effect on matrix metalloproteinase-2 (gelatinase A) and on the binding of TNF&agr; to TNF&agr;-RI.

Abstract: The present invention relates to a herbal chip comprising a plastic slide, a coating as a spacer on the plastic slide, and fractions or components obtained from herbs that are independently allocated in microarrays on the coating. The herbal chip is useful for screening for active ingredients contained in the herbs that have specific pharmacological or therapeutical functions.

Abstract: A compound of formula 1-[3,4-dihydroxy-5-(2-hydroxyethyl) tetrahydrofuran-2-yl]pryimidine-2,4(1H,3H)-dione has inhibitory effects of matrix metalloproteinase-2 (gelatinase A) enzyme and binding of TNF&agr; to TNF&agr;-RI.

Abstract: The present invention discloses a chemically surface-treated plastic slide that is useful for the immobilization of proteins, peptides or small molecules to its surface for the fabrication of biochips. Also disclosed in the present invention is a surface-treated plastic slide made of polystyrene, which is useful for the immobilization of oligonucleotides or polynucleotides to its treated surface for the fabrication of DNA chips.

Abstract: The present invention relates to a herbal chip comprising a plastic slide, a coating as a spacer on the plastic slide, and fractions or components obtained from herbs that are independently allocated in microarrays on the coating. The herbal chip is useful for screening for active ingredients contained in the herbs that have specific pharmacological or therapeutical functions.