Abstract: An imaging system for a biological sample includes a sample container having at least one biological cell that is in contact with an interface surface of a container interface. The imaging system also includes illuminating optics that output a light beam aligned with a sample plane, the light beam being oriented horizontally along a transverse (XY) plane and illuminating the biological cell vertically along an axial (XZ) plane. The imaging system further includes imaging optics aligned horizontally along the transverse (XY) plane with the interface in the sample container, the imaging optics being configured to detect along the axial (XZ) plane a magnified image of a measurable contact angle between the biological cell and the interface surface. The measurable contact angle changes over time and is indicative of biological adhesion between the biological cell and another biological cell.