Abstract: A method includes receiving a first plurality of batches, each of the first plurality of batches including a plurality of scripts identifying a plurality of drug products, respectively, and each of the first plurality of batches defining a first packaging sequence for the plurality of drug products identified by the plurality of scripts; receiving operational status information for each of a plurality of drug product packaging systems; and organizing, using an artificial intelligence engine, the plurality of scripts from the first plurality of batches into a second plurality of batches based on the operational status information received for each of the plurality of drug product packaging systems, the second plurality of batches defining a second packaging sequence for the plurality of drug products identified by the plurality of scripts.