Abstract: Provided herein are combination therapies comprising GDC-9545 and a CDK4/6 inhibitor for treating locally advanced breast cancer or metastatic breast cancer.

Abstract: A method for estimating weight of a payload held by load lifting machine 1, wherein the load lifting machine comprises lifting linkage with a boom 5 pivotably connected to a machine chassis 2, the method comprising calculating an estimation using the torque of the boom 5, torque of the boom during calibration lifts for first and second payloads, and dynamic torque adjustment determined for first and second payloads.

Abstract: A slipper includes a sole, a vamp, and a strap that extends from one side of the vamp to the other. The strap has a generally curved shape with an upper arc, lower arc, and rounded first and second ends. The ends of the strap are connected with the vamp such that the strap is positionable in either a rearward position or a forward position. In the rearward position, the strap supports the heel or ankle of a user. In the forward position, the strap is a vamp cuff. In some versions the strap may be detachable from the vamp altogether. Thus users can choose which strap configuration they desire. In some versions the strap is rotatably positionable and in some other versions the strap is detachable and re-attachable for positioning.

Abstract: A method for estimating weight of a payload held by load lifting machine 1, wherein the load lifting machine comprises lifting linkage with a boom 5 pivotably connected to a machine chassis 2, the method comprising calculating an estimation using the torque of the boom 5, torque of the boom during calibration lifts for first and second payloads, and dynamic torque adjustment determined for first and second payloads.