Abstract: A home appliance having an oven rack including an appliance body having a plurality of oven walls defining an oven cavity; an oven rack for removable disposition in the oven cavity, wherein the oven rack includes two flat side panels and a plurality of straight cross members extending laterally therebetween to define a cooking vessel support surface; and a pair of traveling gliders wherein each glider includes a channel configured for receipt of one of the side panels wherein the oven rack can travel in and out of the oven cavity supported at the side panels by the traveling gliders.

Abstract: A home appliance having an improved gas igniter (or ignitor) including an appliance body, at least one burner assembly supported in the appliance body to provide a heat source for cooking, with the burner assembly including a gas pipe, an igniter in operational communication with the gas pipe, the igniter including a heater element and a shroud covering a portion of the heater element, the shroud including a shroud body defining a chamber having the heater element therein, an inlet opening facing the gas pipe, an outlet opening facing away from the gas pipe, and a constriction intermediate the inlet opening and the outlet opening, thereby defining a fluid flow path through the chamber whereby a fluid stream is directed from the inlet opening, across the heater element, through the constriction to the outlet opening.

Abstract: The present invention relates to the use of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), solids forms, and pharmaceutical compositions thereof for the treatment of CFTR-mediated diseases, particularly cystic fibrosis, in patients possessing specific genetic mutations. The present invention also relates to the use of Compound 1 in combination with 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 2), and Compound 1 in combination with (S)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 3), for the treatment of CFTR-mediated diseases, particularly cystic fibrosis, in patients possessing specific genetic mutations.

Abstract: The present disclosure provides methods for treating Cystic Fibrosis in a subject by administering to the subject a corrector agent capable of acting through MSD1 during the biosynthesis of CFTR protein. The disclosure also provides methods of screening for new corrector agents capable of acting through MSD1 during the biosynthesis of a CFTR protein.

Abstract: The present disclosure provides methods for treating Cystic Fibrosis in a subject by administering to the subject a corrector agent capable of acting through MSD1 during the biosynthesis of CFTR protein. The disclosure also provides methods of screening for new corrector agents capable of acting through MSD1 during the biosynthesis of a CFTR protein.

Abstract: The present invention relates to the use of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), solids forms, and pharmaceutical compositions thereof for the treatment of CFTR-mediated diseases, particularly cystic fibrosis, in patients possessing specific genetic mutations. The present invention also relates to the use of Compound 1 in combination with 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 2), and Compound 1 in combination with (S)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 3), for the treatment of CFTR-mediated diseases, particularly cystic fibrosis, in patients possessing specific genetic mutations.

Abstract: A home appliance having an improved gas igniter (or ignitor) including an appliance body, at least one burner assembly supported in the appliance body to provide a heat source for cooking, with the burner assembly including a gas pipe, an igniter in operational communication with the gas pipe, the igniter including a heater element and a shroud covering a portion of the heater element, the shroud including a shroud body defining a chamber having the heater element therein, an inlet opening facing the gas pipe, an outlet opening facing away from the gas pipe, and a constriction intermediate the inlet opening and the outlet opening, thereby defining a fluid flow path through the chamber whereby a fluid stream is directed from the inlet opening, across the heater element, through the constriction to the outlet opening.

Abstract: The present invention relates to the use of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), solids forms, and pharmaceutical compositions thereof for the treatment of CFTR-mediated diseases, particularly cystic fibrosis, in patients possessing specific genetic mutations. The present invention also relates to the use of Compound 1 in combination with 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 2), and Compound 1 in combination with (S)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 3), for the treatment of CFTR-mediated diseases, particularly cystic fibrosis, in patients possessing specific genetic mutations.

Abstract: A home appliance having an oven rack including an appliance body having a plurality of oven walls defining an oven cavity; an oven rack for removable disposition in the oven cavity, wherein the oven rack includes two flat side panels and a plurality of straight cross members extending laterally therebetween to define a cooking vessel support surface; and a pair of traveling gliders wherein each glider includes a channel configured for receipt of one of the side panels wherein the oven rack can travel in and out of the oven cavity supported at the side panels by the traveling gliders.