Patents by Inventor Jennifer A. Lewis

Jennifer A. Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11897263
    Abstract: A subwavelength resonator for acoustophoretic printing comprises a hollow resonator body for local enhancement of an acoustic field integrated with a nozzle body for delivery of an ink into the acoustic field. The nozzle body has a first end outside the hollow resonator body and a second end inside the hollow resonator body, and includes a fluid channel extending between a fluid inlet at the first end and a fluid outlet at the second end. The fluid channel passes through a side wall of the hollow resonator body and includes at least one bend. During acoustophoretic printing, an ink delivered through the fluid channel of the nozzle body and out of the fluid outlet is exposed to a high-intensity acoustic field.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: February 13, 2024
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Daniele Foresti, Aleksandra Markovic, Jennifer A. Lewis
  • Patent number: 11845219
    Abstract: A 3-D printed device comprising one or more structures, the structures comprising a plurality of magnetically responsive particles and one or more diblock or triblock copolymers; the diblock or triblock copolymers having an A-B, A-B-A, or A-B-C block-type structure in which the A-blocks and C-blocks are an aromatic-based polymer or an acrylate-based polymer and the B-blocks are an aliphatic-based polymer. These 3-D printed devices may be formed using a method that comprises providing a magnetic ink composition; applying the magnetic ink composition to a substrate in a 3-D solvent cast printing process to form one or more structures; and drying the one or more structures formed from the magnetic ink composition. The dried structures can exhibit one or more regions of magnetic permeability greater than 1.3×10?6 H/m.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: December 19, 2023
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Theodore H. Fedynyshyn, Jennifer A. Lewis, Bradley P. Duncan
  • Publication number: 20230398729
    Abstract: A method of controlling macroscopic properties of a metamaterial includes 3D printing a lattice structure comprising interconnected struts, where each strut comprises one or more printed filaments. Each printed filament comprises an active material or a passive material, and the active material has a modulus with a higher stimulus dependence than that of the passive material. The printed filaments comprising the active material are disposed at predetermined regions of the lattice structure. After 3D printing, the lattice structure is exposed to a stimulus, and the predetermined regions comprising the active material soften or stiffen. Thus, the macroscopic properties of the lattice structure may be controlled.
    Type: Application
    Filed: November 11, 2021
    Publication date: December 14, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Jochen MUELLER, Jennifer A. LEWIS, Katia BERTOLDI
  • Patent number: 11759840
    Abstract: A modular roller hemming system having a base assembly, a replaceable anvil, a spider arm assembly, a plurality of support arms for supporting the spider arm assembly, and a plurality of repositionable unit tools. The anvil is 3-D printed of a polymer composite material and may be replaced with similarly manufactured anvils having different form factors for receiving various shaped and dimensioned workpiece assemblies. The plurality of support arms are repositionable on the base assembly, the spider arm assembly is reconfigurable, and the plurality of unit tools are moveable to accommodate various anvils having different form factors. The support arms includes an upper segment that is detachable from the lower segment to facilitate the changeover of anvils.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: September 19, 2023
    Assignee: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Jennifer Lewis, Ronald J. Leslie, Lawrence A. Adamski, Malini Dusey
  • Publication number: 20230287357
    Abstract: Described herein are methods of generating a programmable multicellular organoid and/or a 3D organ-specific tissue. Also, described are the programmable multicellular organoid and/or a 3D organ-specific tissue produced by the described methods. Also, described herein are in vitro methods of generating functional human tissue construct.
    Type: Application
    Filed: July 6, 2021
    Publication date: September 14, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Mark Andrew SKYLAR-SCOTT, Jennifer A. LEWIS, Jeremy Yuenchen HUANG, Jingcheng LU, Tomoya DUENKI
  • Publication number: 20230278278
    Abstract: A method of printing a cellular solid by direct bubble writing comprises introducing an ink formulation comprising a polymerizable monomer and a gas into a nozzle, which includes a core flow channel radially surrounded by an outer flow channel. The ink formulation is directed into the outer flow channel and the gas is directed into the core flow channel. The ink formulation and the gas are ejected out of the nozzle as a stream of bubbles, where each bubble includes a core comprising the gas and a liquid shell overlying the core that comprises the ink formulation. After ejection, the polymerizable monomer is polymerized to form a solid polymeric shell from the liquid shell, and the bubbles are deposited on a substrate moving relative to the nozzle. Thus, a polymeric cellular solid having a predetermined geometry is printed.
    Type: Application
    Filed: May 10, 2023
    Publication date: September 7, 2023
    Applicant: UNIVERSITEIT TWENTE
    Inventors: Claas Willem VISSER, Dahlia Ningrum AMATO, Jennifer A. Lewis, Jochen MUELLER
  • Patent number: 11745420
    Abstract: A method of forming a three-dimensional structure includes forming a layer of resin comprising liquid crystal oligomers and a photoinitiator, applying a magnetic field to the formed layer in a predefined alignment direction for substantially aligning the liquid crystal oligomers in a first orientation; and exposing the formed layer to radiation for curing a first portion of the layer during application of the magnetic field thereby resulting in the first portion having liquid crystal elastomers substantially aligned in the first orientation. The method includes applying a second magnetic field to the formed layer in a predefined second alignment direction for substantially aligning uncured liquid crystal oligomers in a second orientation, and exposing the layer to radiation for curing a second portion of the layer during application of the second magnetic field thereby resulting in the second portion having liquid crystal elastomers substantially aligned in the second orientation.
    Type: Grant
    Filed: June 23, 2022
    Date of Patent: September 5, 2023
    Assignees: Lawrence Livermore National Security, LLC, President and Fellows of Harvard College
    Inventors: Rodrigo Telles Arriaga, Caitlyn Christian Krikorian, Elaine Lee, Jennifer Lewis
  • Patent number: 11685108
    Abstract: A method of printing a cellular solid (120) by direct bubble writing comprises introducing an ink formulation (102) comprising a polymerizable monomer and a gas (104) into a nozzle (106), which includes a core flow channel (108) radially surrounded by an outer flow channel (110). The ink formulation is directed into the outer flow channel (110) and the gas is directed into the core flow channel (108). The ink formulation (102) and the gas (104) are ejected out of the nozzle (106) as a stream of bubbles (112), where each bubble includes a core (114) comprising the gas and a liquid shell (116) overlying the core that comprises the ink formulation. After ejection, the polymerizable monomer is polymerized to form a solid polymeric shell (118) from the liquid shell (116), and the bubbles are deposited on a substrate (122) moving relative to the nozzle (106). Thus, a polymeric cellular solid (120) having a predetermined geometry is printed.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: June 27, 2023
    Assignee: UNIVERSITEIT TWENTE
    Inventors: Claas Willem Visser, Dahlia Ningrum Amato, Jennifer A. Lewis, Jochen Mueller
  • Patent number: 11648106
    Abstract: This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the first and a second materials, or a combination of a second material and one or more other different materials. The bilayer graft devices have two components or layers. One component, e.g., the underlay graft device, can include a projection, and the second component, e.g., the overlay graft device, can include an opening that corresponds to the projection (or vice versa) so that the opening and the projection can secure the two layers together in a “lock and key” manner. This disclosure also features methods of making, using, and implanting the three-dimensional artificial tympanic membrane and bilayer graft devices.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: May 16, 2023
    Assignees: Massachusetts Eye and Ear Infirmary, President and Fellows of Harvard College
    Inventors: Aaron K. Remenschneider, Elliott Kozin, Nicole Leah Black, Michael J. McKenna, Daniel J. Lee, Jennifer A. Lewis, John Rosowski, David B. Kolesky, Mark A. Skylar-Scott, Alexander D. Valentine
  • Publication number: 20230143048
    Abstract: A printhead comprises a plurality of ink cartridges and a nozzle, where the nozzle and the ink cartridges are configured to rotate together about an axis during printing. The nozzle includes a nozzle body comprising an inlet end, an outlet end, and one or more internal passageways extending through the nozzle body from the inlet end to the outlet end. The one or more internal passageways terminate at one or more outlets at or near the outlet end. The nozzle also includes plurality of nozzle inlets at the inlet end for delivery of flowable inks into the internal passageways, where each nozzle inlet is in fluid communication with a dispensing end of one of the ink cartridges.
    Type: Application
    Filed: November 8, 2022
    Publication date: May 11, 2023
    Inventors: Natalie M. Larson, Jochen Mueller, Jennifer A. Lewis
  • Publication number: 20230055790
    Abstract: Described herein are melt-extrudable biodegradable inks for 3D-printing, methods of using the inks, and kits including the inks, to prepare implantable grafts, such as artificial tympanic membrane devices or artificial cartilage, nerve conduit, tendon, muscle tissue, or bone devices.
    Type: Application
    Filed: December 11, 2020
    Publication date: February 23, 2023
    Inventors: Nicole Leah BLACK, Emily DAVIDSON, Jennifer A. LEWIS, Aaron Kyle REMENSCHNEIDER, Elliott D. KOZIN
  • Publication number: 20230049026
    Abstract: A method of forming an innervated liquid crystal elastomer (iLCE) actuator comprises extruding a filament through a nozzle moving relative to a substrate, where the filament has a core-shell structure including a shell comprising a liquid crystal elastomer surrounding a core configured to induce a nematic-to-isotropic transition of the liquid crystal elastomer. The filament is subjected to UV curing as the filament is extruded, and the filament is deposited on the substrate as the nozzle moves. A director of the liquid crystal elastomer is aligned with a print path of the nozzle, and a 3D printed architecture configured for actuation is formed.
    Type: Application
    Filed: May 13, 2022
    Publication date: February 16, 2023
    Inventors: Arda Kotikian, Jennifer A. Lewis, Javier M. Morales Ferrer, John William Boley
  • Patent number: 11559607
    Abstract: Described are devices and methods for use in connection with organ replacement or organ assist therapy in a patient.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: January 24, 2023
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: David B. Kolesky, Kimberly A. Homan, Jennifer A. Lewis, Yen-Chih Lin
  • Patent number: 11498332
    Abstract: A method of acoustophoretic printing comprises generating an acoustic field at a first end of an acoustic chamber fully or partially enclosed by sound-reflecting walls. The acoustic field interacts with the sound-reflecting walls and travels through the acoustic chamber. The acoustic field is enhanced in a chamber outlet at a second end of the acoustic chamber. An ink is delivered into a nozzle positioned within the acoustic chamber. The nozzle has a nozzle opening projecting into the chamber outlet. The ink travels through the nozzle and is exposed to the enhanced acoustic field at the nozzle opening, and a predetermined volume of the ink is ejected from the nozzle opening and out of the acoustic chamber.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: November 15, 2022
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Daniele Foresti, Jennifer A. Lewis, Armand Kurum
  • Patent number: 11472102
    Abstract: In one aspect, the present disclosure provides a nozzle for 3-D printing. The nozzle may include a first nozzle tip defining a first outlet, where the first nozzle tip includes a first channel extending therethrough. The nozzle may further include a second nozzle tip defining a second outlet, where the second nozzle tip includes a second channel extending therethrough, and where the first channel surrounds the second outlet. The second nozzle tip may be retracted longitudinally with respect to the first nozzle tip such that the second outlet of the second nozzle tip is located in the first channel.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: October 18, 2022
    Assignees: President and Fellows of Harvard College, ETH Zurich (Swiss Federal Institute of Technology)
    Inventors: Jennifer A. Lewis, Jochen Mueller, Jordan R. Raney, Kristina Shea
  • Publication number: 20220280993
    Abstract: A modular roller hemming system having a base assembly, a replaceable anvil, a spider arm assembly, a plurality of support arms for supporting the spider arm assembly, and a plurality of repositionable unit tools. The anvil is 3-D printed of a polymer composite material and may be replaced with similarly manufactured anvils having different form factors for receiving various shaped and dimensioned workpiece assemblies. The plurality of support arms are repositionable on the base assembly, the spider arm assembly is reconfigurable, and the plurality of unit tools are moveable to accommodate various anvils having different form factors. The support arms includes an upper segment that is detachable from the lower segment to facilitate the changeover of anvils.
    Type: Application
    Filed: March 2, 2021
    Publication date: September 8, 2022
    Inventors: Jennifer Lewis, Ronald J. Leslie, Lawrence A. Adamski, Malini Dusey
  • Publication number: 20220176694
    Abstract: A subwavelength resonator for acoustophoretic printing comprises a hollow resonator body for local enhancement of an acoustic field integrated with a nozzle body for delivery of an ink into the acoustic field. The nozzle body has a first end outside the hollow resonator body and a second end inside the hollow resonator body, and includes a fluid channel extending between a fluid inlet at the first end and a fluid outlet at the second end. The fluid channel passes through a side wall of the hollow resonator body and includes at least one bend. During acoustophoretic printing, an ink delivered through the fluid channel of the nozzle body and out of the fluid outlet is exposed to a high-intensity acoustic field.
    Type: Application
    Filed: March 23, 2020
    Publication date: June 9, 2022
    Applicant: President and Fellows of Harvard College
    Inventors: Daniele FORESTI, Aleksandra MARKOVIC, Jennifer A. LEWIS
  • Patent number: 11267981
    Abstract: A 3-D printed device comprising one or more interconnect structures, the interconnect structures comprising a plurality of conductive particles and one or more diblock or triblock copolymers; the diblock or triblock copolymers having an A-B, A-B-A, or A-B-C block-type structure in which the A-blocks and C-blocks are an aromatic-based polymer or an acrylate-based polymer and the B-blocks are an aliphatic-based polymer. These 3-D printed devices may be formed using a method that comprises providing a conductive ink composition; applying the conductive ink composition to a substrate in a 3-D solvent cast printing process to form one or more interconnect structures; and drying the one or more interconnect structures formed from the conductive ink composition. The dried interconnect structures exhibit a conductivity equal to or greater than 1×105 S/m without having to be subjected to any post-processing sintering treatment.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: March 8, 2022
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Bradley P. Duncan, Maxwell E. Plaut, Theodore H. Fedynyshyn, Jennifer A. Lewis
  • Patent number: 11214768
    Abstract: Methods of tissue engineering, and more particularly methods and compositions for generating various vascularized 3D tissues, such as 3D vascularized embryoid bodies and organoids are described. Certain embodiments relate to a method of generating functional human tissue, the method comprising embedding an embryoid body or organoid in a tissue construct comprising a first vascular network and a second vascular network, each vascular network comprising one or more interconnected vascular channels; exposing the embryoid body or organoid to one or more biological agents, a biological agent gradient, a pressure, and/or an oxygen tension gradient, thereby inducing angiogenesis of capillary vessels to and/or from the embryoid body or organoid; and vascularizing the embryoid body or organoid, the capillary vessels connecting the first vascular network to the second vascular network, thereby creating a single vascular network and a perfusable tissue structure.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: January 4, 2022
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Jennifer A. Lewis, Mark A. Skylar-Scott, David B. Kolesky, Kimberly A. Homan, Alex H. M. Ng, George M. Church
  • Patent number: 11207831
    Abstract: A 3D printed core-shell filament comprises an elongated core radially surrounded by an outer shell with a barrier layer in between, where the elongated core comprises a ductile polymer and the outer shell comprises a stiff polymer having a Young's modulus higher than that of the ductile polymer. A lightweight lattice structure may comprise a plurality of the 3D printed core-shell filaments deposited in layers.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: December 28, 2021
    Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, ETH ZURICH (SWISS FEDERAL INSTITUTE OF TECHNOLOGY)
    Inventors: Jennifer A. Lewis, Jochen Mueller, Jordan R. Raney, Kristina Shea