Abstract: Detecting analytes using proximity-induced tagmentation, strand invasion, restriction, or ligation is provided herein. In some examples, detecting an analyte includes coupling a donor recognition probe to a first portion of the analyte. The donor recognition probe includes a first recognition element specific to the first portion of the analyte, a first oligonucleotide corresponding to the first portion, and a transposase coupled to the first recognition element and the first oligonucleotide. An acceptor recognition probe is coupled to a second portion of the analyte. The acceptor recognition probe includes a second recognition element specific to the second portion of the analyte and a second oligonucleotide coupled to the second recognition element and corresponding to the second portion. The transposase is used to generate a reporter polynucleotide including the first and second oligonucleotides. The analyte is detected based on the reporter including comprising the first and second oligonucleotides.

Abstract: The present disclosure relates to a hair coloring composition comprising aloe barbadensis leaf juice, direct dyes, polyether-modified polysiloxanes, and alkoxylated nonionic surfactants. The compositions are useful for coloring hair and can be applied directly to the hair, for example, as a spray formulation. The present disclosure also relates to methods for coloring hair and method for making the hair coloring compositions.

Abstract: This document provides methods and materials for modulating one or more properties of transporter proteins. For example, inverted transporter polypeptides including a leader sequence fused to a transporter protein, and methods of using one or more inverted transporter polypeptides to modulate (e.g., stimulate or inhibit) the excitability of one or more cells (e.g., neurons and myocytes) are provided.

Abstract: A networked database management system (DBMS) is disclosed. The DBMS may include a computer accessible data storage including a database, an access control module, a communication module, and a matching module. The database may be remotely located from a plurality of user nodes and a plurality of venue nodes. The remote database may include a plurality of records, wherein the records comprise: user node data, venue node data, and transaction data. The communication module may be in data communication with the data storage and may be configured to receive user node data and venue node data for storage in the database and query requests to retrieve user node data and venue node data from the database.

Abstract: The present invention discloses, in part, therapies for treating hematologic malignancies, including B cell lymphomas and leukemias or B cell related tumors comprising the administration of a CHK1 inhibitor in combination with a B cell depleting antibody. The present invention further includes treating hematologic malignancies, including B cell lymphomas and leukemias, or B cell related tumors, which are resistant to cancer treatment comprising the administration of a CHK1 inhibitor.

Abstract: This invention relates to a scrub pad comprising a scrubbing layer having a periphery along the edges of the layer; a wiping layer having a periphery along the edges of the layer; and an absorbent core layer having a periphery along the edges of the layer comprising at least one absorbent material selected from the group consisting of short-fiber, air-laid nonwoven material, nonwoven plastic batting, cellulosic fibrous web materials, wax coated paper, corrugated paper, fluff pulp, cotton balls, cotton batting, or mixture thereof; wherein the absorbent core layer is located intermediate to the scrubbing layer and the wiping layer and wherein the scrubbing layer, the absorbent core layer and the wiping layer are joined at the periphery of each layer.

Abstract: This invention relates to a scrub pad comprising a scrubbing layer having a periphery along the edges of the layer; a wiping layer having a periphery along the edges of the layer; and an absorbent core layer having a periphery along the edges of the layer comprising at least one absorbent material selected from the group consisting of short-fiber, air-laid nonwoven material, nonwoven plastic batting, cellulosic fibrous web materials, wax coated paper, corrugated paper, fluff pulp, cotton balls, cotton batting, or mixture thereof; wherein the absorbent core layer is located intermediate to the scrubbing layer and the wiping layer and wherein the scrubbing layer, the absorbent core layer and the wiping layer are joined at the periphery of each layer.

Abstract: The present invention comprises spumavirus isolated from humans. More specifically, the spumavirus of the present invention was isolated from humans who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. The spumavirus of the invention can also be used for treatment of conditions in humans due to the presence of rapidly dividing cells and for recombinant live virus vaccination.

Abstract: A portable recording unit (10) for recording the upper airway respiratory sounds of an exercising horse to determine whether the horse suffers from an upper airway obstruction condition. The portable recording unit (10) comprises horse restraining apparatus (200) wherein microphone (12) is mounted on support (14), which is secured to nose-band (202) of horse restraining apparatus (200), and recorder (16). When horse restraining apparatus (200) is mounted onto head (102) of horse (100), microphone (12) is positioned forward to and between nostrils (108) of horse (100). Recorder (16) is fastened to neck (104) of horse (100) or is located at a remote location. Portable recording unit (10) allows recording of the upper airway respiratory sounds made by the exercising horse (100).

Abstract: The present invention comprises a spumavirus isolated from a human. More specifically, the spumavirus of the present invention was isolated from a human who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. The spumavirus of the invention can also be used for treatment of conditions in humans due to the presence of rapidly dividing cells and for recombinant live virus vaccination.

Abstract: The present invention comprises spumavirus isolated from humans. More specifically, the spumavirus of the present invention was isolated from humans who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. The spumavirus of the invention can also be used for treatment of conditions in humans due to the presence of rapidly dividing cells and for recombinant live virus vaccination.

Abstract: The present invention comprises spumavirus isolated from humans. More specifically, the spumavirus of the present invention was isolated from humans who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. The spumavirus of the invention can also be used for treatment of conditions in humans due to the presence of rapidly dividing cells and for recombinant live virus vaccination.

Abstract: A portable recording unit (10) for recording the upper airway respiratory sounds of an exercising horse to determine whether the horse suffers from an upper airway obstruction condition. The portable recording unit (10) comprises horse restraining apparatus (200) wherein microphone (12) is mounted on support (14), which is secured to nose-band (202) of horse restraining apparatus (200), and recorder (16). When horse restraining apparatus (200) is mounted onto head (102) of horse (100), microphone (12) is positioned forward to and between nostrils (108) of horse (100). Recorder (16) is fastened to neck (104) of horse (100) or is located at a remote location. Portable recording unit (10) allows recording of the upper airway respiratory sounds made by the exercising horse (100).

Abstract: The present invention comprises spumavirus isolated from humans. More specifically, the spumavirus of the present invention was isolated from humans who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies.