Abstract: The invention relates to an isolated interleukin-17 (IL-17)-binding agent which comprises an immunoglobulin heavy chain polypeptide comprising SEQ ID NO: 1, SEQ ID NO: 32, SEQ ID NO: 33, SEQ ID NO: 78, or SEQ ID NO: 79, and an immunoglobulin light chain polypeptide comprising SEQ ID NO: 23, except that one or more specific of residues of SEQ ID NO: 1 and SEQ ID NO: 23 are replaced with a different residue. The invention also provides vectors, compositions, and methods of using the IL-17-binding agent to treat an IL-17-mediated disease.

Abstract: A snap-on bed skirt provides an easily installed and removed rigid vertical decorative covering for the sides of a box spring which extends to the floor. The skirt can be provided in a variety of rigid materials and can be decorated with a variety of colors, styles, and materials. The rigid vertical skirts can be quickly installed or removed. Depending upon the design and placement of the bed, two to four panels can be installed. These panels are carefully crafted for a snug and rigid fit on the box spring, either supported by friction or horizontal supports placed between the box spring and mattress, under the box spring, or attached to the bed frame. The corners of the panels would be fastened to each other with corner fasteners.

Abstract: A snap-on bed skirt provides an easily installed and removed rigid decorative covering for the sides of a box spring and extends to the floor. The skirt can be provided in a variety of fabrics, colors and styles, and can be quickly installed or removed. Depending upon the design and placement of the bed, two to four panels can be installed. These panels are carefully crafted for a snug and rigid fit on the box spring, but are made of flexible fabric from the upper edge of the box spring to the floor, to accommodate most bed frames. The corners of the panels would be fastened to each other with removable fasteners. The device would be supported vertically by tension, or optionally by supports located between the mattress and box springs, under the box springs, or on the bed frame.

Abstract: The disclosure relates to an isolated IL-17-binding agent which comprises an immunoglobulin heavy chain polypeptide comprising SEQ ID NO: 1 and optionally an immunoglobulin light chain polypeptide comprising SEQ ID NO: 23, except that one or more specific of residues of SEQ ID NO: 1 and SEQ ID NO: 23 are replaced with a different residue. The disclosure also provides vectors, compositions, and methods of using the IL-17-binding agent to treat an IL-17-mediated disease.