Patents by Inventor Jennifer E. GAGNER

Jennifer E. GAGNER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FLUORESCENCE QUENCHING IMMUNOASSAY
    Publication number: 20220082501
    Abstract: The present invention relates to a method and reagents for determining the presence of or the amount of an analyte in a sample.
    Type: Application
    Filed: April 16, 2021
    Publication date: March 17, 2022
    Inventors: Jennifer E. Gagner, Kiamars Hajizadeh, Evan M. Peck, James R. Salter, Paul J. Travers, Christopher P. Turmel, Yingzi Wu, Hongzhi Xie, Murthy V.S.N. Yerramilli
  • Internalization of proteins into hollowed gold nanostructures
    Patent number: 9562225
    Abstract: Provided is a gold nanocage with pores, charged ligand molecules covalently bound to internal surfaces of the gold nanocage, and payload molecules electrostatically adsorbed onto said charged ligand molecules, wherein a pore diameter is between 1.2 and 20 times a gyration radius of the payload molecule. Also provided is a method for making a nanoparticle, including using polyvinylpyrrolidone as a capping agent in a galvanic replacement reaction to convert a silver nanocube into a gold nanocage having pores, replacing the polyvinylpyrrolidone on internal surfaces with charged ligand molecules, and electrostatically adsorbing payload molecules onto the charged ligand molecules, with a pore diameter less than twenty times a gyration radius of the payload molecule. Also provided is a method of delivering a pharmacological agent to a mammalian cell, including contacting the cell with a gold nanocage having pores, ligand molecules bound to internal surfaces, and pharmacological agent adsorbed onto ligand molecules.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: February 7, 2017
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Xi Qian, Jennifer E. Gagner, Jonathan S. Dordick, Richard W. Siegel
  • INTERNALIZATION OF PROTEINS INTO HOLLOWED GOLD NANOSTRUCTURES
    Publication number: 20160097081
    Abstract: Provided is a gold nanocage with pores, charged ligand molecules covalently bound to internal surfaces of the gold nanocage, and payload molecules electrostatically adsorbed onto said charged ligand molecules, wherein a pore diameter is between 1.2 and 20 times a gyration radius of the payload molecule. Also provided is a method for making a nanoparticle, including using polyvinylpyrrolidone as a capping agent in a galvanic replacement reaction to convert a silver nanocube into a gold nanocage having pores, replacing the polyvinylpyrrolidone on internal surfaces with charged ligand molecules, and electrostatically adsorbing payload molecules onto the charged ligand molecules, with a pore diameter less than twenty times a gyration radius of the payload molecule. Also provided is a method of delivering a pharmacological agent to a mammalian cell, including contacting the cell with a gold nanocage having pores, ligand molecules bound to internal surfaces, and pharmacological agent adsorbed onto ligand molecules.
    Type: Application
    Filed: April 1, 2015
    Publication date: April 7, 2016
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Xi QIAN, Jennifer E. GAGNER, Jonathan S. DORDICK, Richard W. SIEGEL