Abstract: The presently-disclosed subject matter relates to crosslinkers, compositions, and methods for trapping a target of interest on a substrate of interest. The methods may be used to inhibit and treat pathogen infection and provide contraception. The methods may be used to trap or separate particles and other substances. The subject matter further relates to methods of identifying and preparing optimal crosslinkers and methods for manipulating targets of interest.

Abstract: Various methods and systems are provided for designing viral vector libraries using machine learning models. In some embodiments, by training a machine learning model to predict a packaging fitness of a viral vector sequence, a viral vector library may be designed, wherein, for a desired library diversity, an increased packaging fitness may be achieved. In one example, a machine learning model may be trained to predict packaging fitness of a viral vector sequence by encoding the viral vector sequence as a feature set, mapping the feature set to a predicted packaging fitness of the viral vector sequence using a machine learning model, determining a loss based on a difference between a ground truth packaging fitness and the predicted packaging fitness of the viral vector sequence, and updating parameters of the machine learning model based on the loss.

Abstract: The presently-disclosed subject matter relates to crosslinkers, compositions, and methods for trapping a target of interest on a substrate of interest. The methods may be used to inhibit and treat pathogen infection and provide contraception. The methods may be used to trap or separate particles and other substances. The subject matter further relates to methods of identifying and preparing optimal crosslinkers and methods for manipulating targets of interest.

Abstract: This invention relates to an article that evenly cools a liquid in a container such as, for example, milk in an infant bottle, in a relatively short amount of time, without diluting the liquid. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: This invention relates to an article that evenly cools a liquid in a container such as, for example, milk in an infant bottle, in a relatively short amount of time, without diluting the liquid. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.