Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

Abstract: Disclosed are methods for treating a disease or condition characterized by decreased expression or reduced function of an ion channel, comprising administering to a subject in need thereof a therapeutically effective amount of a pore-forming polyene macrolide or pore-forming derivative thereof. For example, the pore-forming polyene macrolide may be amphotericin B (AmB), nystatin, or natamycin. The methods can be used to treat cystic fibrosis.

Abstract: Disclosed are methods for treating a disease or condition characterized by decreased expression or reduced function of an ion channel, comprising administering to a subject in need thereof a therapeutically effective amount of a pore-forming polyene macrolide or pore-forming derivative thereof. For example, the pore-forming polyene macrolide may be amphotericin B (AmB), nystatin, or natamycin. The methods can be used to treat cystic fibrosis.

Abstract: A disk cleaning scrub module comprising a scrub lane and a plurality of brushes that rotates and scrub washes a plurality of disks having a diameter D in the scrub lane, wherein a disk-to-disk center distance for scrub wash of the plurality of the disks is S and a ratio of S/D is greater than 1 and less than 1.6 is disclosed.

Abstract: A disk cleaning scrub module comprising a scrub lane and a plurality of brushes that rotates and scrub washes a plurality of disks having a diameter D in the scrub lane, wherein a disk-to-disk center distance for scrub wash of the plurality of the disks is S and a ratio of S/D is greater than 1 and less than 1.6 is disclosed.