Patents by Inventor Jennifer HOWES

Jennifer HOWES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL IONIZABLE LIPIDS AND LIPID NANOPARTICLES AND METHODS OF USING THE SAME
    Publication number: 20250051263
    Abstract: Novel ionizable lipids and lipid nanoparticles that can be used in the delivery of therapeutic cargos are disclosed.
    Type: Application
    Filed: November 22, 2022
    Publication date: February 13, 2025
    Inventors: Alessandra BARTOLOZZI, John PROUDFOOT, Roman ERDMANN, Arijit ADHIKARI, Siddharth PATEL, Alaina HOWE, Dominick SALERNO, Jennifer UNION
  • METHOD OF SCREENING FOR PEPTIDES CAPABLE OF BINDING TO A UBIQUITIN PROTEIN LIGASE (E3)
    Publication number: 20220236273
    Abstract: The present invention relates to a method of screening for peptides capable of binding to a ubiquitin protein ligase (E3), successful binding being determined by detecting the amount of a test protein in the cell. The invention relates to a method for determining if a peptide binds or is capable of binding to a ubiquitin protein ligase (E3) and thereby leads to degradation of a test protein, wherein the peptide is between about 7 and 110 amino acids in length, the method comprising: providing in a eukaryotic cell a candidate peptide functionally linked to a test protein, under conditions enabling ubiquitination of proteins by an E3; and detecting the amount of test protein present in the cell; whereby, a reduced amount of the test protein determines the candidate peptide as a peptide that binds or is capable of binding to an E3 (an E3-binding peptide).
    Type: Application
    Filed: May 30, 2020
    Publication date: July 28, 2022
    Applicant: Phoremost Limited
    Inventors: Markus MUELLNER, Alberto MORENO, Marta CARRARA, Jennifer HOWES