Publication number: 20050176944
Abstract: Various embodiments of the invention provide human intracellular signaling molecules (INTSIG) and polynucleotides which identify and encode INTSIG. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of INTSIG.
Type:
Application
Filed:
August 16, 2002
Publication date:
August 11, 2005
Inventors:
Henry Yue, Dyung Lu, Anita Swarnakar, Y. Tang, Jennifer Griffin, Brooke Emerling, Ian Forsythe, Monique Yao, Jayalaxmi Ramkumar, Thomas Richardson, Shanya Becha, Ernestine Lee, Bridget Warren, Patricia Lehr-Mason, Mariah Baughn, Joana Li, Brendan Duggan, Kimberly Gietzen, Preeti Lal, Mark Borowsky, Craig Ison, Kavitha Thangavelu, Yuming Xu, Sally Lee, Vicki Elliott, William Sprague, Yalda Azimzai, April Hafalia, Li Ding, Danniel Nguyen, Cynthia Honchell, Wen Luo, Narinder Chawla, Joseph Marquis, Jennifer Jackson, Uyen Tran
Publication number: 20050095587
Abstract: The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce anitbodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.
Type:
Application
Filed:
February 21, 2001
Publication date:
May 5, 2005
Inventors:
Scott Panzer, Peter Shapiro, Steven Banville, Purvi Shah, Michael Chalup, Simon Chang, Alice Chen, Steven D'sa, Stefan Amshey, Christopher Dahl, Tam Dam, Susan Daniels, Gerard Dufour, Vincent Flores, Willy Fong, Lila Greenawalt, Jennifer Jackson, Anissa Jones, Tommy Liu, Ann Roseberry Lincoln, Bruce Rosen, Frank Russo, Theresa Stockdreher, Abel Daffo, Rachel Wright, Pierre Yap, Jimmy Yu, Diana Bradley, Shawn Bratcher, Wensheng Chen, Howard Cohen, David Hodgson, Stephen Lincoln, Stuart Jackson