Patents by Inventor Jennifer Kan
Jennifer Kan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230102728Abstract: This disclosure provides a method of preparing a silanol-functional organosilicon compound with a cytochrome P450 variant that facilitates the oxidization of a silyl hydride group to a silanol group in the presence of oxygen. The method includes combining the cytochrome P450 variant and an organosilicon compound having at least one silicon-bonded hydrogen atom to give a reaction mixture and exposing the reaction mixture to oxygen to oxidize the organosilicon compound, thereby preparing the silanol-functional organosilicon compound. Cytochrome P450 variants suitable for use in the method are also disclosed, along with methods for engineering and optimizing the same. Nucleic acids encoding the cytochrome P450 variants and compositions, expression vectors, and host cells including the same are also disclosed.Type: ApplicationFiled: February 19, 2021Publication date: March 30, 2023Inventors: John ROBERTS, Dimitris Elias KATSOULIS, Susanne BAEHR, Sabine BRINKMANN-CHEN, S.B. Jennifer KAN, Frances H. ARNOLD
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Patent number: 10927355Abstract: The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the present invention provides heme proteins, including variants and fragments thereof, that are capable of carrying out in vitro and in vivo carbene insertion reactions for the formation of carbon-silicon bonds. In other aspects, the present invention provides methods for producing an organosilicon product, the method comprising providing a silicon-containing reagent, a carbene precursor, and a heme protein; and combining the components under conditions sufficient to produce an organosilicon product. Host cells expressing the heme proteins are also provided by the present invention.Type: GrantFiled: September 5, 2018Date of Patent: February 23, 2021Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Sek Bik Jennifer Kan, Russell D. Lewis, Kai Chen, Frances H. Arnold
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Patent number: 10829792Abstract: Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.Type: GrantFiled: March 21, 2018Date of Patent: November 10, 2020Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Kai Chen, Xiongyi Huang, S. B. Jennifer Kan
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Patent number: 10745673Abstract: Provided herein are methods for producing an organoboron product. The methods include combining a boron-containing reagent and a carbene precursor in the presence of a heme protein, e.g., a cytochrome c, a cytochrome P450, a globin, a protoglobin, a nitric oxide dioxygenase, a peroxidase, or a catalase, or a variant thereof, under conditions sufficient to form the organoboron product. Reaction mixtures for producing organoboron products are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming carbon-boron bonds.Type: GrantFiled: March 7, 2018Date of Patent: August 18, 2020Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: S. B. Jennifer Kan, Xiongyi Huang, Kai Chen
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Publication number: 20180371430Abstract: The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the present invention provides heme proteins, including variants and fragments thereof, that are capable of carrying out in vitro and in vivo carbene insertion reactions for the formation of carbon-silicon bonds. In other aspects, the present invention provides methods for producing an organosilicon product, the method comprising providing a silicon-containing reagent, a carbene precursor, and a heme protein; and combining the components under conditions sufficient to produce an organosilicon product. Host cells expressing the heme proteins are also provided by the present invention.Type: ApplicationFiled: September 5, 2018Publication date: December 27, 2018Applicant: California Institute of TechnologyInventors: Sek Bik Jennifer Kan, Russell D. Lewis, Kai Chen, Frances H. Arnold
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Publication number: 20180305721Abstract: Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.Type: ApplicationFiled: March 21, 2018Publication date: October 25, 2018Applicant: California Institute of TechnologyInventors: Kai Chen, Xiongyi Huang, S. B. Jennifer Kan
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Patent number: 10093906Abstract: The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the present invention provides heme proteins, including variants and fragments thereof, that are capable of carrying out in vitro and in vivo carbene insertion reactions for the formation of carbon-silicon bonds. In other aspects, the present invention provides methods for producing an organosilicon product, the method comprising providing a silicon-containing reagent, a carbene precursor, and a heme protein; and combining the components under conditions sufficient to produce an organosilicon product. Host cells expressing the heme proteins are also provided by the present invention.Type: GrantFiled: February 1, 2017Date of Patent: October 9, 2018Assignee: California Institute of TechnologyInventors: Sek Bik Jennifer Kan, Russell D. Lewis, Kai Chen, Frances H. Arnold
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Publication number: 20180273917Abstract: Provided herein are methods for producing an organoboron product. The methods include combining a boron-containing reagent and a carbene precursor in the presence of a heme protein, e.g., a cytochrome c, a cytochrome P450, a globin, a protoglobin, a nitric oxide dioxygenase, a peroxidase, or a catalase, or a variant thereof, under conditions sufficient to form the organoboron product. Reaction mixtures for producing organoboron products are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming carbon-boron bonds.Type: ApplicationFiled: March 7, 2018Publication date: September 27, 2018Applicant: California Institute of TechnologyInventors: S.B. Jennifer Kan, Xiongyi Huang, Kai Chen
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Publication number: 20180148745Abstract: The present invention provides methods by which trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine and related cyclopropane compounds are prepared using synthetic strategies that include a biocatalytic cyclopropanation step.Type: ApplicationFiled: May 26, 2016Publication date: May 31, 2018Applicants: California Institute of Technology, Provivi, Inc.Inventors: Francis H. Arnold, Hans Renata, John A. McIntosh, Russell D. Lewis, Sek Bik Jennifer Kan, Kari Hernandez, Pedro Coelho, David Rozzell, Chen Zhang
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Publication number: 20170218346Abstract: The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the present invention provides heme proteins, including variants and fragments thereof, that are capable of carrying out in vitro and in vivo carbene insertion reactions for the formation of carbon-silicon bonds. In other aspects, the present invention provides methods for producing an organosilicon product, the method comprising providing a silicon-containing reagent, a carbene precursor, and a heme protein; and combining the components under conditions sufficient to produce an organosilicon product. Host cells expressing the heme proteins are also provided by the present invention.Type: ApplicationFiled: February 1, 2017Publication date: August 3, 2017Applicant: California Institute of TechnologyInventors: Sek Bik Jennifer Kan, Russell D. Lewis, Kai Chen, Frances H. Arnold
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Patent number: 4946042Abstract: A readily openable combination shipping and display carton and carton blank are disclosed. The carton is formed from a carton blank having a plurality of tearable lines of weakness such as perforation, perforation/score and dividing lines. At least one removable panel or section is provided and may be removed by tearing along such lines of weakness which at least partially define the removable section. An opening for hand access to remove the removable section is also provided. Two side panel top flaps are provided with a plurality of portions and/or sections which maintain structural integrity and parallelism during shipping and handling and some of which are automatically removed along with removal of the removable section(s).Type: GrantFiled: November 29, 1988Date of Patent: August 7, 1990Assignee: Lever Brothers CompanyInventors: Paul Ferreri, Heinz Maurer, Jennifer Kan, Harry Allers, Michael Lackey