Abstract: Described is the use of a coccidiostatically effective amount of Simarouba amara either alone or in combination with Momordica charantia for the manufacture of a medicament for the therapy of coccidiosis in poultry. Further described is a method for controlling coccidiosis in poultry based on the administering of said medicament. Described is also a poultry feed supplement or medicated poultry feed for the control of coccidiosis in poultry that comprises besides ground dry vegetable- and/or animal-based poultry feed, with or without additives such as proteins, vitamins and minerals, and a coccidiostatically effective amount of Simarouba amara dried bark or an extract thereof either alone or in combination with Momordica charantia fruit extract. Also described is the production of said medicament and to the use of said active ingredients as an additive to dry or wet poultry food or drinking water for the prophylactic or curative treatment of coccidial infections in poultry.