Patents by Inventor Jennifer Koenitzer

Jennifer Koenitzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230131164
    Abstract: The present invention relates to the identification of a genomic integration site for heterologous polynucleotides in Chinese Hamster Ovary (CHO) cells resulting in high RNA and/or protein production. More specifically it relates to CHO cells comprising at least one heterologous polynucleotide stably integrated into the S100A gene cluster of the CHO genome and to methods for the production of said CHO cells. Further, the invention relates to a method for the production of a protein of interest using said CHO cell and to the use of said CHO cell for producing a protein of interest at high yield. Integration within these specific target regions leads to reliable, stable and high yielding production of an RNA and/or protein of interest, encoded by the heterologous polynucleotide.
    Type: Application
    Filed: December 6, 2022
    Publication date: April 27, 2023
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Markus Mueller, Jochen Schaub, Christian Bernloehr, Jennifer Koenitzer
  • Patent number: 11560549
    Abstract: The present invention relates to the identification of a genomic integration site for heterologous polynucleotides in Chinese Hamster Ovary (CHO) cells resulting in high RNA and/or protein production. More specifically it relates to CHO cells comprising at least one heterologous polynucleotide stably integrated into the S100A gene cluster of the CHO genome and to methods for the production of said CHO cells. Further, the invention relates to a method for the production of a protein of interest using said CHO cell and to the use of said CHO cell for producing a protein of interest at high yield. Integration within these specific target regions leads to reliable, stable and high yielding production of an RNA and/or protein of interest, encoded by the heterologous polynucleotide.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: January 24, 2023
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Markus Mueller, Jochen Schaub, Christian Bernloehr, Jennifer Koenitzer
  • Publication number: 20200216815
    Abstract: The present invention relates to the identification of a genomic integration site for heterologous polynucleotides in Chinese Hamster Ovary (CHO) cells resulting in high RNA and/or protein production. More specifically it relates to CHO cells comprising at least one heterologous polynucleotide stably integrated into the 5100A gene cluster of the CHO genome and to methods for the production of said CHO cells. Further, the invention relates to a method for the production of a protein of interest using said CHO cell and to the use of said CHO cell for producing a protein of interest at high yield. Integration within these specific target regions leads to reliable, stable and high yielding production of an RNA and/or protein of interest, encoded by the heterologous polynucleotide.
    Type: Application
    Filed: August 10, 2018
    Publication date: July 9, 2020
    Inventors: Markus Mueller, Jochen Schaub, Christian Bernloehr, Jennifer Koenitzer