Abstract: An article of footwear includes an upper including a chamber, a compressible component disposed within the chamber and operable between a relaxed state and a constricted state, a sole structure including a recess forming a cavity, and a pump device disposed within the cavity and fluidly coupled to the chamber, the pump device operable to transition the compressible component from the relaxed state to the constricted state by removing fluid from the chamber.

Abstract: An article of footwear includes an upper having a chamber, a sole structure including a recess forming a cavity, and a pump device disposed within the cavity, in fluid communication with the chamber, and operable to move the upper from a relaxed state to a constricted state by selectively evacuating fluid from the chamber.

Abstract: Systems and apparatus related to adaptive support garments including adaptive support structures, lacing systems, and an adaptive engine are discussed. In an example, an adaptive support apparel system includes an activity sensor, an adaptive support garment, and a control circuit. The activity sensor monitors activity of a user. The adaptive support garment includes an integrated adaptive support system coupled to the adaptive engine to automatically adjust a portion of the adaptive support garment through manipulation of the adaptive support system. The control circuit configured to send commands to the adaptive engine in response to input received from the activity sensor.

Abstract: A locking structure for an article includes a bladder having a first barrier element attached to a second barrier element to define a chamber including an interior void and a plurality of locking elements disposed within the interior void and each attached to at least one of the first barrier element and the second barrier element, each of the locking elements including an interface surface operable to selectively engage an interface surface of another one of the locking elements.

Abstract: An adjustment element for an article of footwear includes a bladder having a barrier layer defining an interior void and a compressible component disposed within the interior void and including a lattice structure defining a plurality of reliefs formed in the lattice structure, the compressible component operable between an expanded state when the interior void includes a first pressure and a contracted state when the interior void includes a second pressure.

Abstract: The invention provides a variety of compounds having the structure of Formula I and uses of such compounds for treatment of various indications, including cancer as well as methods of treatment involving such compounds are also provided. The uses of the compounds may specifically include: bladder cancer, cholangiocarcinoma; colorectal cancer; diffuse large B-cell lymphoma (DLBC); liver cancer; ovarian cancer; thymoma; thyroid cancer; clear cell renal cell carcinoma (CCRCC); chromophobe renal cell carcinoma (ChRCC); prostate cancer; breast cancer; uterine cancer; pancreatic cancer; cervical cancer; uveal melanoma; acute myeloid leukemia (AML); head and neck cancer; small cell lung cancer (SCLC); lung adenocarcinoma sarcoma; mesothelioma; adenoid cystic carcinoma (ACC), sarcoma; testicular germ cell cancer; uterine cancer; pheochromocytoma and paraganglioma (PCPG); melanoma; glioma; glioblastoma multiforme; T-cell Acute Lymphoblastic Leukemia; T-cell Lympohoma, medulloblastoma; and neuroblastoma.

Abstract: Systems and apparatus related to adaptive support garments including adaptive support structures, lacing systems, and an adaptive engine are discussed. In an example, an adaptive support apparel system includes an activity sensor, an adaptive support garment, and a control circuit. The activity sensor monitors activity of a user. The adaptive support garment includes an integrated adaptive support system coupled to the adaptive engine to automatically adjust a portion of the adaptive support garment through manipulation of the adaptive support system. The control circuit configured to send commands to the adaptive engine in response to input received from the activity sensor.

Abstract: Shoes and/or shoe elements facilitate natural foot motion and/or reduce forces tending to fight natural foot motion. In at least some such structures, a wearer's heel is secured to the hindfoot region of a shoe (e.g., by a strap system) in a manner that permits heel/forefoot rotation and that allows the lower leg to remain straight. In other structures, a shoe can include a heel supporting component that is separate from a midsole component, and this heel supporting component can move toward the lateral side and/or medial side of the shoe along an interface between the heel supporting component and the midsole component. Other suitable shoe and shoe component structures also are described.

Abstract: A shoe can include support members for a plantar surface of a foot that include: (a) a heel support plate; (b) a forefoot support plate; (c) a heel securing strap component for securely engaging a heel supporting component with a wearer's heel; and (d) a unidirectional hinge, wherein the hinge allows the heel support plate to rotate internally with respect to the forefoot support plate and limit the heel support plate from rotating externally with respect to the forefoot support plate. The support member allows the shoe to twist and move with the foot, allowing the ankle to remain neutral, rather than the shoe fighting the foot's natural motion. The unidirectional nature of the hinge plate also prevents the shoe from rotating externally beyond a predetermined limit point.

Abstract: Shoes and/or shoe elements facilitate natural foot motion and/or reduce forces tending to fight natural foot motion. In at least some such structures, a wearer's heel is secured to the hindfoot region of a shoe (e.g., by a strap system) in a manner that permits heel/forefoot rotation and that allows the lower leg to remain straight. In other structures, a shoe can include a heel supporting component that is separate from a midsole component, and this heel supporting component can move toward the lateral side and/or medial side of the shoe along an interface between the heel supporting component and the midsole component. Other suitable shoe and shoe component structures also are described.

Abstract: Shoes and/or shoe elements facilitate natural foot motion and/or reduce forces tending to fight natural foot motion. In at least some such structures, a wearer's heel is secured to the hindfoot region of a shoe (e.g., by a strap system) in a manner that permits heel/forefoot rotation and that allows the lower leg to remain straight. In other structures, a shoe can include a heel supporting component that is separate from a midsole component, and this heel supporting component can move toward the lateral side and/or medial side of the shoe along an interface between the heel supporting component and the midsole component. Other suitable shoe and shoe component structures also are described.

Abstract: A shoe can include support members for a plantar surface of a foot that include: (a) a heel support plate; (b) a forefoot support plate; (c) a heel securing strap component for securely engaging a heel supporting component with a wearer's heel; and (d) a unidirectional hinge, wherein the hinge allows the heel support plate to rotate internally with respect to the forefoot support plate and limit the heel support plate from rotating externally with respect to the forefoot support plate. The support member allows the shoe to twist and move with the foot, allowing the ankle to remain neutral, rather than the shoe fighting the foot's natural motion. The unidirectional nature of the hinge plate also prevents the shoe from rotating externally beyond a predetermined limit point.