Abstract: The present invention provides a blood parameter sensing system that may include a sensor, a blood access system, a flow controller and a monitor system. The blood access system may include a blood draw member having an internal configuration adapted to avoid clotting without the use of anticoagulants and under a range of flow profiles, including small volume blood draws. The flow controller may be configured to adapt to a range of access devices by using feedback from the sensor and monitor to customize flow profiles. The monitor system is configured to reduce parameter measurement error by modeling sensitivity change during system startup or reconnect.

Abstract: Embodiments of the present invention provide a blood analyte sensing system (10) that includes an integral calibrant concentration measurement system. The blood analyte sensing system includes a blood sensor (22), a calibration system and the calibrant concentration measurement system. The calibrant concentration measurement system is connected in communication with both the calibration system and the blood sensor. The calibration concentration measurement system includes a calibrant sensor (20) configured to measure a calibrant concentration in response to exposure to the calibrant. The calibration concentration measurement system is also configured to determine the analyte concentration of the patient's blood using the calibrant concentration, calibration signal and the blood signal.