Abstract: A hemostasis valve assembly includes a housing and a valve member. The housing includes a central bore. The valve member is positioned within the housing and includes opposed first and second primary surfaces, a thickness, an opening, and first and second slits. The valve thickness is defined between the first and second primary surfaces. The opening is formed in the first primary surface. The first and second slits intersect each other and extend through a portion of the valve thickness. At least one of the first and second slits is accessible within the opening.

Abstract: A catheter includes an inflation balloon and at least one electrode. The inflation balloon is inflatable within a vessel. The at least one electrode extends around at least a portion of a periphery of the inflation balloon. The at least one electrode is expandable as the inflation balloon is inflated, and contracts as the inflation balloon is deflated. The at least one electrode is held in place along a length of the inflation balloon with a tether member, which is secured at opposing distal and proximal ends of the inflation balloon.

Abstract: A catheter includes an inflation balloon and at least one electrode. The inflation balloon is inflatable within a vessel. The at least one electrode extends around at least a portion of a periphery of the inflation balloon. The at least one electrode is expandable as the inflation balloon is inflated, and contracts as the inflation balloon is deflated. The at least one electrode is held in place along a length of the inflation balloon with a tether member, which is secured at opposing distal and proximal ends of the inflation balloon.

Abstract: A hemostasis valve assembly includes a housing and a valve member. The housing includes a central bore. The valve member is positioned within the housing and includes opposed first and second primary surfaces, a thickness, an opening, and first and second slits. The valve thickness is defined between the first and second primary surfaces. The opening is formed in the first primary surface. The first and second slits intersect each other and extend through a portion of the valve thickness. At least one of the first and second slits is accessible within the opening.

Abstract: The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided.

Abstract: The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided.

Abstract: The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided.

Abstract: The instant invention provides an inert DNA sequence having a length of between about 0.5 kb and about 5 kb, wherein said isolated inert DNA sequence does not contain an open reading frame and which is suitable for efficient packaging of expression cassettes comprising a nucleic sequence encoding a therapeutic agent into viral vectors, as well as methods of selecting such inert DNA sequences. The invention also provides DNA constructs and medical composition comprising such inert DNA sequences, and kits and medical systems for delivering such DNA constructs and/or compositions.