Abstract: A tissue closure device includes a suture extending longitudinally from a proximal end to a distal end; a distal barb element including at least one distal arm extending from a first end connected to the distal end of the suture to a second end extending toward the proximal end of the suture, the distal barb movable between an engaging configuration, in which the distal arm extends away from the suture; to a non-engaging configuration in which the distal arm is moved toward the suture; and a proximal barb element slidably mounted over the suture and including a proximal arm extending from a first end connected to a base portion mounted over the suture to a second extending toward the distal end of the suture, the proximal barb element movable between an engaging configuration and a non-engaging configuration.

Abstract: A tissue closure device includes a first mesh, a second mesh, and a locking element. The first mesh is sized and shaped to be adhered to a first portion of tissue along a first edge of a tissue opening. The second mesh element is sized and shaped to be adhered to a second portion of tissue along a second edge of the tissue opening substantially opposing the first edge so that the drawing the first and second elements toward one another closes the tissue opening. The locking element is configured to draw the first and second mesh elements toward one another to a sealing position sealing the tissue opening and to lock the first and second mesh elements in the sealing position.