Patents by Inventor Jennifer Melrose
Jennifer Melrose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10018621Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: GrantFiled: June 13, 2013Date of Patent: July 10, 2018Assignee: Eurofins Discoverx CorporationInventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Patent number: 9734282Abstract: Methods and systems for evaluating biological dataset profiles relating to inflammatory cardiovascular conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.Type: GrantFiled: March 28, 2006Date of Patent: August 15, 2017Assignee: DISCOVERX CORPORATIONInventors: Jennifer Melrose, Elen Rosler, Melissa Fischer, Sylvie Privat, Eric J. Kunkel, Ellen Berg
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Publication number: 20130266967Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: ApplicationFiled: June 13, 2013Publication date: October 10, 2013Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Patent number: 8467970Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: GrantFiled: November 17, 2003Date of Patent: June 18, 2013Assignee: DiscoveRx CorporationInventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Patent number: 8019551Abstract: Methods and systems for evaluating biological dataset profiles relating to asthma and other atopic conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.Type: GrantFiled: February 17, 2005Date of Patent: September 13, 2011Assignee: Bioseek LLCInventors: Elen S. Rosler, Eric J. Kunkel, Sylvie Privat, Jennifer Melrose, Melissa Fischer, Ellen L. Berg
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Patent number: 7912651Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: GrantFiled: March 6, 2001Date of Patent: March 22, 2011Assignee: BioSeek LLCInventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose, Ivan Plavec
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Patent number: 7908089Abstract: Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.Type: GrantFiled: May 27, 2004Date of Patent: March 15, 2011Assignee: BioSeek LLCInventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Publication number: 20090118133Abstract: Methods and systems for evaluating biological dataset profiles relating to inflammatory cardiovascular conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.Type: ApplicationFiled: March 28, 2006Publication date: May 7, 2009Inventors: Jennifer Melrose, Elen Rosler, Melissa Fischer, Sylvie Privat, Eric J. Kunkel, Ellen Berg
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Publication number: 20080070271Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: ApplicationFiled: October 30, 2007Publication date: March 20, 2008Inventors: Ellen Berg, Eugene Butcher, Jennifer Melrose, Ivan Plavec
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Publication number: 20080064056Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: ApplicationFiled: October 30, 2007Publication date: March 13, 2008Inventors: Ellen Berg, Eugene Butcher, Jennifer Melrose
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Publication number: 20080020417Abstract: Methods and systems for evaluating biological dataset profiles relating to asthma and other atopic conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.Type: ApplicationFiled: February 17, 2005Publication date: January 24, 2008Applicant: BIOSEEK, INC,Inventors: Elen Rosler, Eric Kunkel, Sylvie Privat, Jennifer Melrose, Melissa Fischer, Ellen Berg
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Publication number: 20070072246Abstract: Compositions and methods are provided for the classification of biologically active agents according to their effect on human biology, through the use of complex, primary human cell-based disease models in scalable assay formats. The systems of the invention utilize the simultaneous activation of multiple signaling pathways to generate and identify patterns of expression of physiologically important cell surface and secreted molecules. Combinations of multiple cell types may be utilized. Systems encompassing multiple cell types not only respond to perturbations of each cell type's intracellular signaling networks, but also to inhibition of pathways of communication between cells. Readout information may be combined in multi-system analysis, where the profiles obtained from multiple systems are combined in order to provide enhanced resolution for agent classification.Type: ApplicationFiled: September 2, 2004Publication date: March 29, 2007Inventors: Ellen Berg, Jennifer Melrose, Eric Kunkel
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Publication number: 20040219592Abstract: Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.Type: ApplicationFiled: May 27, 2004Publication date: November 4, 2004Applicant: BioSeek, Inc.Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Publication number: 20040157269Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: ApplicationFiled: November 17, 2003Publication date: August 12, 2004Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Patent number: 6763307Abstract: Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.Type: GrantFiled: September 13, 2001Date of Patent: July 13, 2004Assignee: BioSeek, Inc.Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Publication number: 20040063088Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: ApplicationFiled: September 11, 2003Publication date: April 1, 2004Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose, Ivan Plavec
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Patent number: 6656695Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: GrantFiled: March 6, 2001Date of Patent: December 2, 2003Assignee: Bioseek, Inc.Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Publication number: 20030113807Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.Type: ApplicationFiled: March 6, 2001Publication date: June 19, 2003Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose
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Publication number: 20030017445Abstract: Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.Type: ApplicationFiled: September 13, 2001Publication date: January 23, 2003Inventors: Ellen L. Berg, Eugene C. Butcher, Jennifer Melrose