Abstract: Systems and methods for facilitating the establishment of pharmaceutical rebate agreements or arrangements may be provided. One or more rebate offers associated with one or more pharmaceutical products manufactured by the drug manufacturer may be received from a drug manufacturer via a network. One or more respective conditions associated with the one or more rebate offers may be established by the drug manufacturer. At least a portion of the one or more rebate offers may be electronically presented to a payer of pharmaceutical benefits. A selection of at least one of the presented rebate offers may be received from the payer via the network. The selection may initiate an enrollment of the payer for the at least one selected rebate offer.