Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: An illuminated purse assembly includes a purse for carrying objects. A set of first light emitters is each positioned within an interior of the purse to illuminate the interior of the purse. A set of second light emitters is each positioned within an interior of the purse to illuminate the interior of the purse. A light sensor is positioned within the purse to sense light when the purse is opened. The light sensor turns on each of the first and second light emitters when the light sensor senses light. An electronic timer is coupled to the purse and the electronic timer counts down an operation duration of time when the light sensor senses light. Each of the first and second light emitters is turned off when the operation duration of time elapses.

Abstract: A method for automatically delaying playback of a message at a captioning device may include obtaining, at the captioning device, a request to playback of the message. The method may also include, in response to the request, automatically delaying the playback of the message at the captioning device in order to allow the captioning system to receive the audio of the message from a beginning of the playback of the audio of the message.

Abstract: Described herein are methods and kits for eliminating or reducing drug target interference and improving drug tolerance in anti-drug antibody (ADA), pharmacokinetic, biomarker, or toxicological assays. The method comprises heating the biological assay sample to reduce target binding to the drug.

Abstract: A method for automatically delaying playback of a message at a captioning device may include obtaining, at the captioning device, a request to playback of the message. The method may also include, in response to the request, automatically delaying the playback of the message at the captioning device in order to allow the captioning system to receive the audio of the message from a beginning of the playback of the audio of the message.

Abstract: A method for automatically delaying playback of a voice message at a captioning device may include receiving, at a captioning device, a request from a user to play back a voice message that is stored on the captioning device. The method may also include, in response to the request from the user, automatically delaying the playback of the voice message, at the captioning device, until an establishment of a connection between the captioning device and a remote call assistant, in order to allow the remote call assistant to caption on the captioning device, in real-time, the voice message from the very beginning of the playback of the voice message.

Abstract: Described are systems and methods for communicating emergency alerts to a hearing-impaired user. Queries are performed to one or more emergency alert databases to develop emergency alert notifications. At least some of the emergency alert notifications are filtered responsive to user selected criteria to select one or more filtered emergency alerts. An attention desired indicator is transmitted to a hearing-impaired user device that subscribes to a hearing-impaired relay service supported by the server if the one or more filtered emergency alerts are present. The filtered emergency alerts are transmitted to the hearing-impaired user device in response to a emergency information query from that user device.

Abstract: Described are systems and methods for communicating emergency alerts to a hearing-impaired user. Queries are performed to one or more emergency alert databases to develop emergency alert notifications. At least some of the emergency alert notifications are filtered responsive to user selected criteria to select one or more filtered emergency alerts. An attention desired indicator is transmitted to a hearing-impaired user device that subscribes to a hearing-impaired relay service supported by the server if the one or more filtered emergency alerts are present. The filtered emergency alerts are transmitted to the hearing-impaired user device in response to a emergency information query from that user device.

Abstract: Systems and methods for communicating emergency alerts to a hearing-impaired user are disclosed. Queries are performed to one or more emergency alert databases to develop emergency alert notifications. At least some of the emergency alert notifications are filtered responsive to user selected criteria to select one or more filtered emergency alerts. An attention desired indicator is transmitted to a hearing-impaired user device that subscribes to a hearing-impaired relay service supported by the server if the one or more filtered emergency alerts are present. The filtered emergency alerts are transmitted to the hearing-impaired user device in response to a emergency information query from that user device.

Abstract: Method(s), system(s), apparatus(es), and computer program products are provided that can index, monitor, inventory, and/or monetize digital assets, such as documents, photographs, videos, blogs, online accounts, social media accounts, e-mail accounts, online banking accounts, etc.

Abstract: Systems and methods for communicating emergency alerts to a hearing-impaired user are disclosed. Queries are performed to one or more emergency alert databases to develop emergency alert notifications. At least some of the emergency alert notifications are filtered responsive to user selected criteria to select one or more filtered emergency alerts. An attention desired indicator is transmitted to a hearing-impaired user device that subscribes to a hearing-impaired relay service supported by the server if the one or more filtered emergency alerts are present. The filtered emergency alerts are transmitted to the hearing-impaired user device in response to a emergency information query from that user device.

Abstract: A composition for carrying out a chemical or biochemical reaction, said composition being in a freeze-dried form and comprising (i) a set of reagents comprising at least some of the chemical or biochemical reagents necessary for conducting said chemical or biochemical reaction, (ii) a glass forming agent, (iii) a stabilising agent therefore and (iv) fish gelatine. In particular compositions for carrying out PCR are foreseen. Kits comprising these compositions and methods for using them form a further aspect of the invention.

Abstract: A composition for carrying out a chemical or biochemical reaction, said composition being in a freeze-dried form and comprising (i) a set of reagents comprising at least some of the chemical or biochemical reagents necessary for conducting said chemical or biochemical reaction, including at least one reagent which is fluorescent (ii) a glass forming agent, and (iii) threonine. Kits comprising these compositions and methods of using them form a further aspect of the invention.

Abstract: The present invention provides a method of mitigating a symptom of maladaptive substance use in a subject by inhibiting CCKB receptors. In addition, the invention provides a variety of prescreening and screening methods aimed at identifying agents that modulate a symptom of maladaptive substance use. Methods of the invention can involve assaying test agent binding to CCKB receptors. Alternatively, test agents can be screened for their ability to alter the level of CCKB receptor polypeptides, polynucleotides, or function. Finally, the invention also provides a diagnostic method that entails measuring one or more of these levels and determining risk for maladaptive substance use based on comparison to the corresponding level for a control population.

Abstract: This invention relates to a composite board including: a core having upper and lower surfaces and at least one aperture extending therebetween, at cast one upper reinforcing layer disposed on the upper surface of the core and at least one lower reinforcing layer disposed on the lower surface of the core, the upper and lower reinforcing layers each including at least one aperture extending therethrough, the apertures in the upper and lower reinforcing layers being in substantial alignment with each other and with the aperture or apertures in the core, at least one tie member passing through the substantially aligned apertures, each said tie member having a first end portion protruding through said aligned apertures from said upper reinforcing layer and a second end portion protruding through said aligned apertures from a said lower reinforcing layer, said first and second end portions being secured to a surface of said respective lyaers.

Abstract: System and methods for intelligent routing of requests from customers to agents where a request is received at a service center from a customer. Identification information related to the customer is accessed. Background information on the customer is retrieved from a storage facility. Task and attitude information about the customer is gathered. A model of the customer is created. Models for at least two agents are created. A performance optimizing calculation is performed that matches the customer model and the models for the at least two agents. A best match agent from the at least two agents is determined based on the matching. The customer request is routed to the best match agent.