Abstract: One example embodiment is adapted for use in facilitating collection and transport of memory devices, e.g., drives, motherboards, etc., e.g., for the purposes of subsequent destruction. The example embodiment has an outer bin, also called a garage or outer enclosure, within which is placed an inner bin with wheels. Once closed and locked, the outer bin has a door that can be opened so drives or other memory devices can be inserted. The drives then fall into the inner bin and, once sufficiently filled, the inner bin be easily wheeled out from the outer bin. The inner bin has its own locking lid that is secured when transporting the inner bin with the drives, e.g., to a destruction facility or area. Other features are provided as described below. Enhanced synergistic security features include use of multi-point locking latches to secure doors and lids, metal construction of the bins, and so on. The bins are sized to facilitate efficient collection and transport of potentially sensitive data center media.

Abstract: Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate.

Abstract: The present disclosure relates to methods and compositions for modulating protein expression. In particular, the invention features methods and compositions for increasing protein expression in a cell by delivering to the cell a composition including an mRNA encoding a polypeptide and one or more oligonucleotides, wherein each of the one or more oligonucleotides includes a region of linked nucleotides complimentary to a portion of the sequence of the mRNA. The methods and compositions described herein may be used to modulate gene expression (e.g., increase gene expression), to increase the stability of the mRNA, to decrease the immunogenicity of the mRNA, to enable selective expression (e.g., in a target cell or tissue) of the mRNA, and/or to enable the delivery of two or more mRNAs in a stoichiometric ratio.

Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.

Abstract: Provided are electrochemically active particles suitable for use as an active material in a cathode of a lithium ion electrochemical cell that include: a plurality of crystallites comprising a first composition comprising lithium, nickel, and oxygen; and a grain boundary between adjacent crystallites of the plurality of crystallites and comprising a second composition comprising lithium, nickel, and oxygen; wherein the grain boundary has a higher electrochemical affinity for lithium than the crystallites. The higher electrochemical affinity for Li leads to increased Li retention in the grain boundaries during or at charge relative to the bulk crystallites and stabilizes the structure of the grain boundaries and crystallites for improved cycling stability with no appreciable loss in capacity.

Abstract: Provided are methods of preparing an electrochemically active cathode material including the steps of (a) combining an alkali metal-containing layered nickel oxide having a formula A1?aNi1+aO2, wherein A comprises an alkali metal and 0<a?0.2, with an oxidant comprising a peroxydisulfate salt and/or a monopersulfate salt to form a mixture, (b) heating the mixture to form a Ni(IV) containing mixture including a Ni(IV) containing electrochemically active cathode material; (c) adding to the Ni(IV) containing mixture of step (b) a mineral acid; and (d) heating the mixture of step (c) to form an additional amount of the Ni(IV) containing electrochemically active cathode material, the Ni(IV) containing electrochemically active cathode material formed in steps (b) and (d) having a general formula AxHyNi1+aO2, wherein A comprises an alkali metal; 0.08?x<0.2; 0?y<0.3; and 0.02?a?0.2.

Abstract: The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-(1S,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.

Abstract: Systems and methods for simulating the insertion of a device via cannulation include an external shell which is at least partially filled with a silicone material, a simulated venous flow path, a simulated arterial flow path, one or more pumps to provide fluid to these flow paths, and a visible atrium in fluid communication with the venous flow path. The venous and arterial flow paths are made of flexible and distensible tubing, which is at least partially embedded within the silicone material in cannulation regions, and which is configured to be pierced to allow for insertion of a device therein. The atrium comprises a translucent front wall to enable, before, during, or after insertion of the device, visible inspection inside of the atrium.

Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.

Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.

Abstract: The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl) cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.

Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.

Abstract: The invention is directed towards an electrochemically active cathode material. The electrochemically active cathode includes beta-delithiated layered nickel oxide and an electrochemically active cathode material selected from the group consisting of manganese oxide, manganese dioxide, electrolytic manganese dioxide (EMD), chemical manganese dioxide (CMD), high power electrolytic manganese dioxide (HP EMD), lambda manganese dioxide, gamma manganese dioxide, beta manganese dioxide, and mixtures thereof. The beta-delithiated layered nickel oxide has an X-ray diffraction pattern. The X-ray diffraction pattern of the beta-delithiated layered nickel oxide includes a first peak from about 14.9°2? to about 16.0°2?; a second peak from about 21.3°2? to about 22.7°2?; a third peak from about 37.1°2? to about 37.4°2?; a fourth peak from about 43.2°2? to about 44.0°2?; a fifth peak from about 59.6°2? to about 60.6°2?; and a sixth peak from about 65.4°2? to about 65.9°2?.

Abstract: One example embodiment is adapted for use in facilitating collection and transport of memory devices, e.g., drives, motherboards, etc., e.g., for the purposes of subsequent destruction. The example embodiment has an outer bin, also called a garage or outer enclosure, within which is placed an inner bin with wheels. Once closed and locked, the outer bin has a door that can be opened so drives or other memory devices can be inserted. The drives then fall into the inner bin and, once sufficiently filled, the inner bin be easily wheeled out from the outer bin. The inner bin has its own locking lid that is secured when transporting the inner bin with the drives, e.g., to a destruction facility or area. Other features are provided as described below. Enhanced synergistic security features include use of multi-point locking latches to secure doors and lids, metal construction of the bins, and so on. The bins are sized to facilitate efficient collection and transport of potentially sensitive data center media.

Abstract: The invention is directed towards an electrochemically active cathode material. The electrochemically active cathode includes beta-delithiated layered nickel oxide and an electrochemically active cathode material selected from the group consisting of manganese oxide, manganese dioxide, electrolytic manganese dioxide (EMD), chemical manganese dioxide (CMD), high power electrolytic manganese dioxide (HP EMD), lambda manganese dioxide, gamma manganese dioxide, beta manganese dioxide, and mixtures thereof. The beta-delithiated layered nickel oxide has an X-ray diffraction pattern. The X-ray diffraction pattern of the beta-delithiated layered nickel oxide includes a first peak from about 14.9° 2? to about 16.0° 2?; a second peak from about 21.3° 2? to about 22.7° 2?; a third peak from about 37.1° 2? to about 37.4° 2?; a fourth peak from about 43.2° 2? to about 44.0° 2?; a fifth peak from about 59.6° 2? to about 60.6° 2?; and a sixth peak from about 65.4° 2? to about 65.9° 2?.

Abstract: Provided are methods of preparing an electrochemically active cathode material including the steps of combining an alkali metal-containing nickel oxide having a formula A1?aNi1+aO2, wherein A comprises an alkali metal and 0<a?0.2, with a fluid composition including an oxidant comprising a peroxydisulfate salt, a monopersulfate salt, or a combination thereof to form a mixture, heating the mixture to a temperature of 50° C. or greater; and maintaining the mixture at the temperature for at least a period of time sufficient to form an alkali metal-deficient nickel oxide electrochemically active cathode material having a general formula AxHyNi1+aO2.nH2O, wherein A comprises an alkali metal; 0.08?x<0.2; 0?y<0.3; 0.02?a?0.2; and 0<n<2.

Abstract: The invention is directed towards an electrochemically active cathode material for a battery. The electrochemically active cathode material includes a non-stoichiometric beta-delithiated layered nickel oxide. The non-stoichiometric beta-delithiated layered nickel oxide has a chemical formula. The chemical formula is LixAyNi1+a?zMzO2.nH2O where x is from about 0.02 to about 0.20; y is from about 0.03 to about 0.20; a is from about 0.02 to about 0.2; z is from about 0 to about 0.2; and n is from about 0 to about 1. Within the chemical formula, A is an alkali metal. The alkali metal includes potassium, rubidium, cesium, and any combination thereof. Within the chemical formula, M comprises an alkaline earth metal, a transition metal, a non-transition metal, and any combination thereof.

Abstract: The invention is directed towards an electrochemically active cathode material for a battery. The electrochemically active cathode material includes a non-stoichiometric beta-delithiated layered nickel oxide. The non-stoichiometric beta-delithiated layered nickel oxide has a chemical formula. The chemical formula is LixAyNi1+a-zMzO2•nH2O where x is from about 0.02 to about 0.20; y is from about 0.03 to about 0.20; a is from about 0.02 to about 0.2; z is from about 0 to about 0.2; and n is from about 0 to about 1. Within the chemical formula, A is an alkali metal. The alkali metal includes potassium, rubidium, cesium, and any combination thereof. Within the chemical formula, M comprises an alkaline earth metal, a transition metal, a non-transition metal, and any combination thereof.

Abstract: The present disclosure relates to methods for preparing a modified RNA comprising enzymatically ligating an acceptor moiety having a 3?-hydroxyl group to the 5?-end of a donor moiety (e.g., installation of 5?-triphosphate groups, mRNA caps, or cap-like structures on chemically synthesized RNA or installation of 5?-triphosphate groups, mRNA caps, cap-like structures, or non-cap like structures on enzymatically prepared RNA).

Abstract: The present invention concerns one or more bacteria cultures of the genus Bacillus, Lysinibacillus or Pseudomonas, a composition comprising the bacteria cultures, the use of the bacteria cultures for preventing and/or reducing amount of free fatty acids and a method for washing.