Abstract: In one embodiment, the disclosure provides a computer-implemented method, comprising receiving, by a computer system, electronic digital data representing a first text sequence in a first language, the first text sequence comprising unstructured natural language text; by one or more machine-learning models of the computer system, determining a score corresponding to the first text sequence, the score being determined by one or more rule-based filters and indicating one or more predicted tones; determining whether to modify the first text sequence based on the score of the first text sequence; in response to a determination to modify the first text sequence, modifying the first text sequence, the modifying comprising replacement of at least one or more words of the first text sequence to result in creating and digitally storing a second text sequence; and transmitting a graphical control element indicative of a tone associated with the second text sequence for display.

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

Abstract: Embodiments of the invention include instruments and methods useful in preparing and delivering graft material to a surgical site. Some embodiments may particularly be directed to forming a graft from a blood clot and accurately and effectively handling and delivering the graft to a surgical site. Graft material may include blood components such as clotted fibrin derived from a patient's or a donor's blood.

Abstract: Methods for whip-stitching soft tissue with a needle and a looped suture avoid placing the tissue graft through the suture loop, which also eliminates the need for passing a tissue clamp through the suture loop. The methods described herein can also include combinations of the techniques described.

Abstract: A suture passer which is sized and shaped to be inserted through the femoral notch during a meniscal repair. The suture passer includes upper and lower jaws that may be straight or that may have an angled offset in relation to the common axis of the suture passer in order to gain an indirect access to meniscal tissue in a constricted space. The jaws of the suture passer may be angled, either to the left or to the right, up to 45 degrees from the central axis of the shaft. The suture passer is also able to grasp meniscal tissue prior to suture passing. A nitinol needle housed within one of the jaws can then be deployed to pass a preloaded suture through the tissue to be captured on the opposite side of the tissue.

Abstract: Embodiments of the disclosure are directed to a ligament repair system and method. The ligament repair system may include one or more of a femoral aimer assembly, a tibial aimer assembly, a femoral fixation assembly, and a tibial fixation assembly.

Abstract: Embodiments of the invention include an anchoring system (1) and method of inserting an anchor (100). Suture (305) and graft (550) may be implanted with anchors (100) of some embodiments. Some anchor embodiments may include at least one side that is cut away (115) to provide a protected space, such as central portion (116), for suture (305) and graft (550) and may provide a connection mechanism, such as a connector hole (107), that may be pushed or pulled by an inserter (200) of the anchoring system (1).

Abstract: Embodiments of the invention include instruments and methods useful in preparing and delivering graft material to a surgical site. Some embodiments may particularly be directed to forming a graft from a blood clot and accurately and effectively handling and delivering the graft to a surgical site. Graft material may include blood components such as clotted fibrin derived from a patient's or a donor's blood.

Abstract: Provided are methods, kits, and systems useful in the performance of analysis and reporting of highly polymorphic loci, including, in particular, the performance of analysis and reporting of HLA typing. Combining one-step sequencing and sequence-specific oligonucleotide probe hybridization, the methods, kits, and systems offer improved efficiency of HLA typing while providing detailed sequencing information. In certain embodiments the methods and systems comprise one or more software applications to facilitate data acquisition, processing, and reporting.

Abstract: Methods for whip-stitching soft tissue with a needle and a looped suture avoid placing the tissue graft through the suture loop, which also eliminates the need for passing a tissue clamp through the suture loop. The methods described herein can also include combinations of the techniques described.

Abstract: A double lead interference screw useful for securing a soft tissue graft inside a bone tunnel of a bone mass is disclosed. The interference screw has continuous independent double threads having uniform pitch, helix angle, and crest height throughout the threaded portions of the screw; a bulbous head; a threaded proximal section with a cylindrical root, a threaded distal section with a tapered root, and a threaded tapered distal tip. Methods for soft tissue repair using the double lead interference screw are also disclosed.

Abstract: Methods for whip-stitching soft tissue with a needle and a looped suture avoid placing the tissue graft through the suture loop, which also eliminates the need for passing a tissue clamp through the suture loop. The methods described herein can also include combinations of the techniques described.

Abstract: Methods for whip-stitching soft tissue with a needle and a looped suture avoid placing the tissue graft through the suture loop, which also eliminates the need for passing a tissue clamp through the suture loop. The methods described herein can also include combinations of the techniques described.

Abstract: Provided are methods of phase-defined genotyping of both alleles of the glycosyltransferase (ABO) locus of a human subject. In certain embodiments the methods include a sequencing step using next-generation sequencing. In certain embodiments the methods include a sequencing step using sequencing-by-synthesis. In certain embodiments the methods further include the steps of comparing contiguous composite nucleotide sequences to a library of reference genomic sequences encoding a region comprising exon (6) and exon (7) of the ABO locus, and identifying individual contiguous composite nucleotide sequences as either (i) a sequence encoding a region comprising a known exon (6) and exon (7) of the ABO locus, or (ii) a sequence encoding a region comprising a novel exon (6) and/or exon (7) of the ABO locus. Also provided are kits for phase-defined genotyping of both alleles of the ABO locus of a human subject.

Abstract: A suture passer which is sized and shaped to be inserted through the femoral notch during a meniscal repair. The suture passer includes upper and lower jaws that may be straight or that may have an angled offset in relation to the common axis of the suture passer in order to gain an indirect access to meniscal tissue in a constricted space. The jaws of the suture passer may be angled, either to the left or to the right, up to 45 degrees from the central axis of the shaft. The suture passer is also able to grasp meniscal tissue prior to suture passing. A nitinol needle housed within one of the jaws can then be deployed to pass a preloaded suture through the tissue to be captured on the opposite side of the tissue.

Abstract: Provided are methods, kits, and systems useful in the performance of analysis and reporting of highly polymorphic loci, including, in particular, the performance of analysis and reporting of HLA typing. Combining one-step sequencing and sequence-specific oligonucleotide probe hybridization, the methods, kits, and systems offer improved efficiency of HLA typing while providing detailed sequencing information. In certain embodiments the methods and systems comprise one or more software applications to facilitate data acquisition, processing, and reporting.

Abstract: A system and method provides a user interface on an electronic device with a listing of the most recently used or viewed items that is organized by the category of item. A menu containing the most recently read items is separated into separate categories such as books and periodicals. The menu displays the most recently opened item in each of the categories. In this manner, one category will not dominate over the other categories on the menu.

Abstract: A system and method provides a user interface on an electronic device with a listing of the most recently used or viewed items that is organized by the category of item. A menu containing the most recently read items is separated into separate categories such as books and periodicals. The menu displays the most recently opened item in each of the categories. In this manner, one category will not dominate over the other categories on the menu.

Abstract: A system and method for displaying periodical digital content. A device sorts and organizes the periodical content stored on the device according to the title of the periodical and further according the dates of the periodicals. Each periodical, e.g., newspapers and magazines, after sorting, are displayed on the device's user interface on its own virtual shelf according to the periodical, and then preferably in chronological order within the shelf that is dedicated to the periodical. Alternatively, the periodicals are sorted by issue date, and virtual shelves are dedicated specific date ranges, e.g., “Today,” “This Week,” “This Month.

Abstract: A growth hormone secretagogue is useful for enhancing the return of patients to independent living status following acute deconditioning such as that which may result from immobilization, surgery, or major injury such as hip fracture.