Patents by Inventor Jennifer Nielsen-Kahn

Jennifer Nielsen-Kahn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assays for resistance to echinocandin-class drugs
    Patent number: 8753819
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: June 17, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer Nielsen Kahn, Stephen A. Parent, Rosemarie Kelly
  • Assays for Resistance to Echinocandin-Class Drugs
    Publication number: 20100075302
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Application
    Filed: July 26, 2006
    Publication date: March 25, 2010
    Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, MERCK & CO.
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer Nielsen Kahn, Stephen A. Parent, Rosemarie Kelly
  • Novel sordarin derivative isolated from culture fermentations and functions as an antifungal agent
    Publication number: 20040242904
    Abstract: A novel sordarin derivative was isolated from fungal cultures. The compound is useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops. Two novel cultures of fungi, ATCC No. PTA-3862 and ATCC No. PTA-3861 can be used to ferment and produce the present compound.
    Type: Application
    Filed: June 3, 2004
    Publication date: December 2, 2004
    Inventors: Angelo Basilio, Javier Collado, Maria Teresa Diez, Ziqiang Guan, Guy H Harris, Michael C Justice, Jennifer Nielsen-Kahn, Mythili S Shastry
  • Protein elongation factor 2 as a target for antifungal and antiparasitic agents
    Publication number: 20020160441
    Abstract: Inhibition of protein elongation factor 2 provides a target for identifying potential antifungal and antiparasitic compounds. EF2 inhibitors are useful as therapeutic agents against fungal and parasitic infections.
    Type: Application
    Filed: April 24, 2002
    Publication date: October 31, 2002
    Applicant: Merck & Co., Inc.
    Inventors: Jennifer Nielsen-Kahn, Michael C. Justice, Dennis M. Schmatz, Ming-Jo Hsu, Theresa W. Ku
  • 11-hydroxysordarin and a process for producing it using actinomyces SSP
    Patent number: 6228622
    Abstract: 11-hydroxysordarin, biotransformation product of a fermentation with sordarin and Actinomyces spp., (Merck Culture Collection MA7235) ATCC No. 202103 is an antifungal agent. This compound may be useful in the treatment of diseases caused by fungal pathogens such as Candida albicans.
    Type: Grant
    Filed: October 26, 1999
    Date of Patent: May 8, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Michael G. Sturr, Michel M. Chartrain, Guy H. Harris, Jennifer Nielsen-Kahn, Brian Heimbuch
  • Protein elongation factor 2 as a target for antifungal and antiparasitic agents
    Patent number: 6096511
    Abstract: Inhibition of protein elongation factor 2 provides a target for identifying potential antifungal and antiparasitic compounds. EF2 inhibitors are useful as therapeutic agents against fungal and parasitic infections.
    Type: Grant
    Filed: June 2, 1998
    Date of Patent: August 1, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Jennifer Nielsen-Kahn, Michael C. Justice, Dennis M. Schmatz, Ming-Jo Hsu, Theresa W. Ku
  • 4-cyano-4-deformylsordarin derivatives
    Patent number: 5972996
    Abstract: 4-Cyano-4-deformylsordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: October 26, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Jennifer Nielsen-Kahn, Bruce Tse
  • DNA encoding 1,3 beta-D glucan synthase subunits
    Patent number: 5821353
    Abstract: DNA molecules encoding proteins involved in biosynthesis of 1,3-beta-D glucan are identified, cloned, expressed and used in in vitro assays to screen for antifungal compounds, including compounds that affect cell wall biosynthesis. The invention includes but is not limited to the purified DNA molecules, assays employing the DNA molecules, proteins encoded by the DNA molecules, cells expressing the DNA molecules and altered forms of the molecules.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: October 13, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Cameron M. Douglas, Gary L. Chrebet, Joseph Clemas, Mohammed El-Sherbeini, Forrest Foor, Jennifer Nielsen Kahn, Rosemarie Kelly, Jean A. Marrinan, Nancy R. Morin, Janet C. Onishi, Stephen Authur Parent, Naasa M. Ramadan, Elizabeth A. Register, Gan-Ju Shei