Abstract: A system and method for processing promotions in connection with digital purchasing. Data associated with a digital purchase request made by a consumer (the data comprising a token, an amount associated with the transaction, a promotional code for each item included in the digital purchase request associated with a promotion, a default transaction amount, and a single default promotional code) is received from a merchant server. The single default promotional code is assigned to all items included in the digital purchase request that are associated with promotions. Using the token, account information associated with the consumer is retrieved from a database. For each promotional code received, promotional information is retrieved. The retrieved promotional information is displayed. The digital purchase request is submitted for processing using the single default promotional code.

Abstract: Disclosed are systems and methods for rapid generation of simulations of a patient's spinal morphology that enable pre-operative viewing of a patient's condition and to assist surgeons in determining the best corrective procedure and with any of the selection, augmentation or manufacture of spinal devices based on the patient specific simulated condition. The simulation is generated by morphing a generic spine model with a three-dimensional curve representation of the patient's particular spinal morphology derived from existing images of the patient's condition.

Abstract: The invention refers to a method and a device for the phenotypic detection of carbapenemases and carbapenemase producers by adding a substrate of general formula A-(L)-M1-(X)—Z, where M1 is a carbapenem backbone, A or Z is a quencher, the other one of the two, Z or A, is a fluorophore, L is an optional linker, X is an optional leaving group for linking Z to the carbapenem backbone, and Z is an optional leaving group, to a sample suspected of containing such carbapenemase producers and/or carbapenenmases. The invention further refers to a method for the phenotypic detection of resistant bacteria, in particular 3MRGN or 4MRGN, by releasing the enzymes of a bacterial culture into a lysate during lysis and then subjecting the lysate, as the sample to be analyzed, to an aforementioned method in order to phenotypically detect the presence of resistance-conferring carbapenemases.

Abstract: The present invention relates to a dimensionally stable adhesive compound which is formulated so as to be largely water- and solvent-free and can be brought into contact with the substrate to be bonded by being wiped on in the form of a thin adhesive film that is suitable in particular for bonding materials obtained from plant fibers. The organic constituent of the adhesive compound according to the invention consists predominantly of polyester polyurethanes, at least some of which are based on semi-crystalline polyester polyols. The invention also relates to a method for applying a tacky film to a planar substrate, preferably to paper, by wiping the adhesive compound onto the point of contact with the substrate.

Abstract: The present invention relates to a dimensionally stable adhesive compound which is formulated so as to be largely water- and solvent-free and can be brought into contact with the substrate to be bonded by being wiped on in the form of a thin adhesive film that is suitable in particular for bonding materials obtained from plant fibers. The organic constituent of the adhesive compound according to the invention consists predominantly of a mixture of polyether polyurethanes which are end-capped with at least two monohydric aliphatic alcohols of different chain lengths. The invention also relates to a method for applying a tacky film to a planar substrate, preferably to paper, by wiping the adhesive compound onto the point of contact with the substrate.

Abstract: The invention refers to a method and a device for the phenotypic detection of carbapenemases and carbapenemase producers by adding a substrate of general formula A-(L)-M1-(X)—Z, where M1 is a carbapenem backbone, A or Z is a quencher, the other one of the two, Z or A, is a fluorophore, L is an optional linker, X is an optional leaving group for linking Z to the carbapenem backbone, and Z is an optional leaving group, to a sample suspected of containing such carbapenemase producers and/or carbapenenmases. The invention further refers to a method for the phenotypic detection of resistant bacteria, in particular 3MRGN or 4MRGN, by releasing the enzymes of a bacterial culture into a lysate during lysis and then subjecting the lysate, as the sample to be analyzed, to an aforementioned method in order to phenotypically detect the presence of resistance-conferring carbapenemases.

Abstract: A method for detecting resistant germs in a sample includes contacting the sample by a sample carrier which has an agent for killing different germs. In addition, the method includes introducing the sample carrier into an analyzer and detecting light emissions from the sample carrier by the analyzer. An indication is output by the analyzer indicating that the sample contains at least one germ resistant to the agent for killing different germs, if the light emission exceeds a threshold value, or indicating that the sample does not contain germs resistant to the agent for killing different germs, if the light emission does not exceed the threshold value.

Abstract: A method for detecting resistant germs in a sample includes contacting the sample by a sample carrier which has an agent for killing different germs. In addition, the method includes introducing the sample carrier into an analyzer and detecting light emissions from the sample carrier by the analyzer. An indication is output by the analyzer indicating that the sample contains at least one germ resistant to the agent for killing different germs, if the light emission exceeds a threshold value, or indicating that the sample does not contain germs resistant to the agent for killing different germs, if the light emission does not exceed the threshold value.

Abstract: A device for detecting resistant bacteria includes a microfluidic chip, a detector and an analyzer. The microfluidic chip includes fluidic structures having a fluid inlet and an interaction chamber fluidically connected to the fluid inlet, and a labeled substrate that is immobilized inside the interaction chamber and enters into a verifiable interaction with bacterial factors of bacteria, so that by introducing a culture medium containing an active substance to be analyzed and the bacteria into the interaction chamber and by detecting the result of the verifiable interaction, it can be ascertained whether the bacteria are resistant to the active substance to be analyzed. The detector detects information that is a measure of whether or not the verifiable interaction has taken place. On the basis of the detected information, the analyzer outputs a display regarding the resistance of the bacteria to the active substance to be analyzed.

Abstract: A security tag for being mounted to a container seal includes a sensor element having a sensor volume which is filled at least partly with an indicator material, an indication area arranged at the sensor volume, and a manipulator element configured to cause, with an abrupt mechanical deformation at the container seal, when opening same, an irreversible, physical and/or chemical alteration of the indicator material which may be perceived visibly or in a tactile manner in the indication area.

Abstract: A security tag for being mounted to a container seal includes a sensor element having a sensor volume which is filled at least partly with an indicator material, an indication area arranged at the sensor volume, and a manipulator element configured to cause, with an abrupt mechanical deformation at the container seal, when opening same, an irreversible, physical and/or chemical alteration of the indicator material which may be perceived visibly or in a tactile manner in the indication area.

Abstract: The present invention relates to peptides and antibodies which bind to melanoma inhibitory activity protein and the uses of such peptides and antibodies. The invention also relates to nucleic acids coding for such peptides or antibodies. The invention also relates to pharmaceutical compositions comprising such peptides or antibodies or such nucleic acids. The present invention also relates to small molecule compounds which bind to melanoma inhibitory activity protein and to uses of such small molecule compounds. Moreover, the present invention also relates to a method of preventing dimerization and/or aggregation of melanoma inhibitory activity (MIA) protein. The invention is based on the identification of the relevant sites of interaction of the MIA protein with the inhibitory peptides/antibodies.

Abstract: The invention relates to ?-ethoxysilane modified polymers of the average general formula (I): in which R is a mono- to tetravalent polymer radical, not more than a third of the radicals R1, R2, and R3 present in the polymer of the formula (I), independently of one another, are alkyl radicals having 1 to 4 carbon atoms, at least a quarter of the radicals R1, R2, and R3 present in the polymer of the formula (I), independently of one another, are ethoxy radicals, any remaining radicals R1, R2, and R3, independently of one another, are methoxy radicals, and in which n is 1 to 4. The invention further relates to a process for preparing the polymers of the formula (I), and also to their use in adhesives, sealants, and coating materials.

Abstract: The present disclosure relates to silane-crosslinking adhesives or sealants comprising a) at least one polymer of the general formula (I) in which R is a monovalent to tetravalent hydrocarbon radical, R1 is an alkyl radical having 1 to 8 C atoms, R2 is an alkyl or alkoxy radical having 1 to 8 C atoms, and A is a carboxyl, carbamate, carbonate, ureido, urethane or sulfonate linker or an oxygen atom, x is 1 to 8, and n is 1 to 4, and b) at least one adhesion promoter, dryer and/or reactive diluent. The adhesion promoters, dryers, and/or reactive diluents are ethoxy-functional ?-silanes of the general formula (II) in which R3 is an organic radical attached to the methylene group via a heteroatom, and R4 is an alkyl radical having 1 to 8 C atoms or an ethoxy radical. The disclosure further relates to a process for producing the adhesives or sealants, and also to their use.

Abstract: The invention relates to ?-ethoxysilane modified polymers of the average general formula (I): in which R is a mono- to tetravalent polymer radical, not more than a third of the radicals R1, R2, and R3 present in the polymer of the formula (I), independently of one another, are alkyl radicals having 1 to 4 carbon atoms, at least a quarter of the radicals R1, R2, and R3 present in the polymer of the formula (I), independently of one another, are ethoxy radicals, any remaining radicals R1, R2, and R3, independently of one another, are methoxy radicals, and in which n is 1 to 4. The invention further relates to a process for preparing the polymers of the formula (I), and also to their use in adhesives, sealants, and coating materials.

Abstract: The present disclosure provides a silane crosslinking adhesive, sealant or coating containing a polymer, consisting of an organic framework that supports at least two alkoxy or acyloxysilyl groups and at least one filler. The filler consists at least partially of a highly disperse silicic acid with a BET surface area of 35 to 65 m2/g and is present in the adhesive, sealant or coating in a quantity of 1 to 60% by weight, in relation to the total weight of said adhesive, sealant or coating. The disclosure also provides the use of the adhesive, sealant or coating for bonding plastics, metal, glass, ceramics, wood or wood-based material, paper, paper-based material, rubber and textiles.