Abstract: N-Acylated histidine dipeptides of formula are disclosed. The compounds are useful for treating breast cancer.

Abstract: A process for preparing solid dispersions of highly crystalline compounds. The highly crystalline or thermally labile therapeutic compounds are processed in an extruder in combination with a solubilizing agent and optionally a plasticizer. The resulting extrudate features the therapeutic compound in an amorphous state. Particularly useful as the solubilizing agents are surfactants such as poloxamers.

Abstract: A process for preparing solid dispersions of highly crystalline compounds. The highly crystalline or thermally labile therapeutic compounds are processed in an extruder in combination with a solubilizing agent and optionally a plasticizer. The resulting extrudate features the therapeutic compound in an amorphous state. Particularly useful as the solubilizing agents are surfactants such as poloxamers.

Abstract: The present invention relates to galenic formulations wherein the active ingredient aliskiren, preferably, a hemi-fumarate salt thereof, alone or in combination with another active ingredient, is melt-granulated and is present in an amount of more than 20% by weight based on the total weight of the oral dosage form, as well as a process of preparing said solid oral dosage form.

Abstract: In one embodiment, a method includes identifying at least one socially relevant gesture associated with a user and identifying at least one gesture graph that identifies content associated with at least one undesirable entity. The at least one socially relevant gesture is identified while the user is interacting with a system. The content includes a plurality of socially relevant gestures associated with the at least one undesirable entity. The method also includes determining when a distance between the at least one socially relevant gesture associated with the user and the content indicates that the user is undesirable, and processing the user as being undesirable when the distance indicates that the user is undesirable.

Abstract: A process for preparing solid dispersions of highly crystalline compounds. The highly crystalline or thermally labile therapeutic compounds are processed in an extruder in combination with a solubilizing agent and optionally a plasticizer. The resulting extrudate features the therapeutic compound in an amorphous state. Particularly useful as the solubilizing agents are surfactants such as poloxamers.

Abstract: A lens blocking device is disclosed that includes a frame, a light source mounted on the frame, a carriage having a first end and a second end mounted on the frame for sliding movement between first and second positions, a first mirror mounted on the carriage first end and a lens block holder mounted on the carriage second end and shiftable between third and fourth positions with respect to the carriage, a stage disposed between the light source and the carriage, and including an opening, for supporting an object, an at least partially translucent screen generating a display image operably connected to the support frame, at least one second mirror arranged to reflect an image of an object on the stage from the first mirror, when the carriage is in the first position, onto the screen, and an actuator operably connected to the carriage.

Abstract: A lens blocking device is disclosed that includes a frame, a light source mounted on the frame, a carriage having a first end and a second end mounted on the frame for sliding movement between first and second positions, a first mirror mounted on the carriage first end and a lens block holder mounted on the carriage second end and shiftable between third and fourth positions with respect to the carriage, a stage disposed between the light source and the carriage, and including an opening, for supporting an object, an at least partially translucent screen generating a display image operably connected to the support frame, at least one second mirror arranged to reflect an image of an object on the stage from the first mirror, when the carriage is in the first position, onto the screen, and an actuator operably connected to the carriage.

Abstract: The disclosed invention relates to a system and method for aligning reference marks defining the optical center or major reference point on a lens blank with a series of alignment marks, or “fiducials”. The fiducials comprise first and second alignment bars displayed on a display operably associated with a computer, and overlay the reference marks, also displayed on the display. The fiducials may be adjusted to accurately precisely align the lens blank.

Abstract: A lens blocking device is disclosed that includes a frame, a light source mounted on the frame, a carriage having a first end and a second end mounted on the frame for sliding movement between first and second positions, a first mirror mounted on the carriage first end and a lens block holder mounted on the carriage second end and shiftable between third and fourth positions with respect to the carriage, a stage disposed between the light source and the carriage, and including an opening, for supporting an object, an at least partially translucent screen generating a display image operably connected to the support frame, at least one second mirror arranged to reflect an image of an object on the stage from the first mirror, when the carriage is in the first position, onto the screen, and an actuator operably connected to the carriage.

Abstract: The disclosed invention relates to a system and method for aligning reference marks defining the optical center or major reference point on a lens blank with a series of alignment marks, or “fiducials”. The fiducials comprise first and second alignment bars displayed on a display operably associated with a computer, and overlay the reference marks, also displayed on the display. The fiducials may be adjusted to accurately precisely align the lens blank.

Abstract: A lens blocking device is disclosed that includes a frame, a light source mounted on the frame, a carriage having a first end and a second end mounted on the frame for sliding movement between first and second positions, a first mirror mounted on the carriage first end and a lens block holder mounted on the carriage second end and shiftable between third and fourth positions with respect to the carriage, a stage disposed between the light source and the carriage, and including an opening, for supporting an object, an at least partially translucent screen generating a display image operably connected to the support frame, at least one second mirror arranged to reflect an image of an object on the stage from the first mirror, when the carriage is in the first position, onto the screen, and an actuator operably connected to the carriage.

Abstract: The disclosed invention relates to a system and method for aligning reference marks defining the optical center or major reference point on a lens blank with a series of alignment marks, or “fiducials”. The fiducials comprise first and second alignment bars displayed on a display operably associated with a computer, and overlay the reference marks, also displayed on the display. The fiducials may be adjusted to accurately precisely align the lens blank.