Patents by Inventor Jennifer Van Eyk

Jennifer Van Eyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200292558
    Abstract: Described herein are methods for identification/discovery of protein biomarkers for chronic kidney disease (CKD) and diagnosing and/or prognosing and/or predicting progression of and/or treating chronic kidney disease (CKD).
    Type: Application
    Filed: October 12, 2018
    Publication date: September 17, 2020
    Applicants: Cedars-Sinai Medical Center, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jennifer VAN EYK, Qin FU, Vidya VENKATRAMAN, Zongming FU, Josef CORESH
  • Publication number: 20200217854
    Abstract: Provided herein are methods, kits, and assays for identifying and quantifying a mitochondrial protein in a sample using mass spectrometry. Also provided herein are methods, kits, and assays for determining a mitochondrial protein biomarker signature for a subject using mass spectrometry.
    Type: Application
    Filed: September 25, 2018
    Publication date: July 9, 2020
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Sarah Parker, Aleksandr Stotland, Roberta Gottlieb, Jennifer Van Eyk, Weston Spivia
  • Publication number: 20190383832
    Abstract: The present disclosure relates to methods for diagnosing and evaluating a subject that has sustained or may have sustained an injury to the head, such as a traumatic brain injury (TBI). In particular, the present disclosure identifies various biomarkers, the detection and/or differential expression of which can be used to assess the presence or absence of a TBI in a subject, and can be used as a basis for diagnosing a subject as having a specific type of TBI (e.g., severe TBI or subclasses of mild TBI). The various TBI biomarkers can be detected individually or in combination and can be used as an important diagnostic, prognostic, and/or TBI risk stratification tool as part of assessing a subject's TBI status.
    Type: Application
    Filed: December 27, 2018
    Publication date: December 19, 2019
    Inventors: Jennifer Van Eyk, Beth McQuiston, Saul Datwyler, Raj Chandran, Vidya Venkatraman, Shenyan Zhang
  • Publication number: 20190369114
    Abstract: Sample preparation for proteomic analysis of complex biological samples by mass spectrometry is a tedious and time-consuming process with many steps where technical variations can be introduced and propagated. We describe an automated trypsin digestion workflow that yields uniformly-processed samples in less than 5 hours. Reproducible quantitation of hundreds of peptides from numerous proteins was seen across replicates, days, instruments, and laboratory sites, demonstrating the broad applicability of this approach.
    Type: Application
    Filed: July 18, 2019
    Publication date: December 5, 2019
    Applicant: Cedars-Sinai Medical Center
    Inventors: Jennifer VAN EYK, Qin FU, Vidya VENKATRAMAN, Irina TCHERNYSHYOV
  • Patent number: 10352942
    Abstract: Described herein are methods for identifying signature peptides for quantifying a polypeptide of interest in a sample. The methods include cleaving the polypeptide into peptides; detecting a multiplicity of the peptides with a quantitative analytical instrument; comparing the linearity of signals attributable to pairs of the peptides in a multiplicity of samples; and selecting signature peptides from a group of peptides with more highly correlated signals.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: July 16, 2019
    Assignees: Cedars-Sinai Medical Center, The Johns Hopkins University
    Inventors: Eric Grote, Qin Fu, Jennifer Van Eyk, Vidya Venkatraman
  • Publication number: 20190025333
    Abstract: Described herein are methods for assessing the risk of cardiovascular disease in a subject in need thereof by detecting the presence of one or more cleavage products of the one or more natriuretic peptides over a period of time, wherein the presence of one or more cleavage products is indicative of an increased risk of the subject developing cardiovascular disease. Provided herein are compositions and kits comprising a non-natural natriuretic peptide comprising one or more D-amino acids. Also provided herein are methods of diagnosing a subject for a disease and treating the subject for the disease, wherein the method comprises the use of a non-natural natriuretic peptide comprising one or more D-amino acids.
    Type: Application
    Filed: October 4, 2018
    Publication date: January 24, 2019
    Applicant: Cedars-Sinai Medical Center
    Inventors: Shenyan ZHANG, Koen RAEDSCHELDERS, Jennifer VAN EYK
  • Publication number: 20180299467
    Abstract: Provided herein are methods and markers for diagnosing cardiovascular disease and/or neurodegenearative diseases in a subject. The methods include obtaining a biological sample from a subject in need of diagnosis and detecting the amount of a citrullinated protein or a citrullinated peptide in the biological sample obtained from said subject.
    Type: Application
    Filed: June 20, 2016
    Publication date: October 18, 2018
    Applicant: Cedars-Sinai Medical Center
    Inventors: Jennifer VAN EYK, Justyna FERT-BOBER, Erin CROWGEY, Ronald HOLEWINSKI, Benjamin Phillip BERMAN
  • Publication number: 20180136220
    Abstract: Described herein are methods for identifying signature peptides for quantifying a polypeptide of interest in a sample. The methods include cleaving the polypeptide into peptides; detecting a multiplicity of the peptides with a quantitative analytical instrument; comparing the linearity of signals attributable to pairs of the peptides in a multiplicity of samples; and selecting signature peptides from a group of peptides with more highly correlated signals.
    Type: Application
    Filed: May 31, 2016
    Publication date: May 17, 2018
    Applicants: Cedars-Sinai Medical Center, The John Hopkins University
    Inventors: Eric GROTE, Qin FU, Jennifer Van Eyk, Vidya VENKATRAMAN
  • Patent number: 9746481
    Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injuries. Brain injury can include overt or traumatic brain injury, as well as subclinical brain injury (SCI). In one embodiment, a method for diagnosing SCI in a patient comprises (a) collecting a sample from the patient; (b) measuring the levels of a panel of biomarkers in the sample collected from the patient, wherein the panel of biomarkers comprises ASTN1, BAI3, CNDP1, ERMIN, GFAP, GRM3, KLH32, MAGE2, NRG3, NRGN, OMG, SLC39A12, RTN1, and MT3; and (c) comparing the levels of the panel of biomarkers with predefined levels of the same panel of biomarkers that correlate to a patient having SCI and predefined levels of the same panel of biomarkers that correlate to a patient not having SCI, wherein a correlation to one of the predefined levels provides the diagnosis.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: August 29, 2017
    Assignee: The Johns Hopkins University
    Inventors: Allen Dale Everett, James Francis Casella, Jennifer Van Eyk
  • Patent number: 9678086
    Abstract: The present invention relates to the field of Alzheimer's disease (AD). More specifically, the present invention provides methods and compositions useful in diagnosing and assessing AD. In another embodiment, a method for diagnosing Alzheimer's Disease (AD) in a patient comprises the steps of (a) obtaining CSF sample from the patient; (b) adding to the sample isotopically labeled peptides identical to a portion of one or more biomarker proteins, wherein the one or more biomarker proteins comprise total APP, APP isoform 751, APP isoform 770, amyloid beta 40 peptide, APOE, and Clusterin; and (c) measuring the one or more biomarker proteins in the sample using mass spectrometry, wherein the level of one or more biomarker proteins compared to a control correlates with AD in the patient.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: June 13, 2017
    Assignee: The Johns Hopkins University
    Inventors: Jennifer Van Eyk, Xiaogian Liu, Richard O'Brien
  • Publication number: 20150212098
    Abstract: The present invention relates to the field of Alzheimer's disease (AD). More specifically, the present invention provides methods and compositions useful in diagnosing and assessing AD. In another embodiment, a method for diagnosing Alzheimer's Disease (AD) in a patient comprises the steps of (a) obtaining CSF sample from the patient; (b) adding to the sample isotopically labeled peptides identical to a portion of one or more biomarker proteins, wherein the one or more biomarker proteins comprise total APP, APP isoform 751, APP isoform 770, amyloid beta 40 peptide, APOE, and Clusterin; and (c) measuring the one or more biomarker proteins in the sample using mass spectrometry, wherein the level of one or more biomarker proteins compared to a control correlates with AD in the patient.
    Type: Application
    Filed: September 10, 2013
    Publication date: July 30, 2015
    Inventors: Jennifer Van Eyk, Xiaogian Liu, Richard O'Brien
  • Patent number: 9039994
    Abstract: This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: May 26, 2015
    Assignee: The Johns Hopkins University
    Inventors: Jennifer Van Eyk, Simon Sheng, Qin Fu
  • Publication number: 20150051115
    Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injuries. Brain injury can include overt or traumatic brain injury, as well as subclinical brain injury (SCI). In one embodiment, a method for diagnosing SCI in a patient comprises (a) collecting a sample from the patient, (b) measuring the levels of a panel of biomarkers in the sample collected from the patient, wherein the panel of biomarkers comprises ASTN1, BAI3, CNDP1, ERMIN, GFAP, GRM3, KLH32, MAGE2, NRG3, NRGN, OMG, SLC39A12, RTN1, and MT3; and (c) comparing the levels of the panel of biomarkers with predefined levels of the same panel of biomarkers than correlate to a patient having SCI and predefined levels of the same panel of biomarkers that correlate to a patient not having SCI, wherein a correlation to one of the predefined levels provides the diagnosis.
    Type: Application
    Filed: October 27, 2014
    Publication date: February 19, 2015
    Inventors: Allen Dale Everett, James Francis Casella, Jennifer van Eyk
  • Publication number: 20140274765
    Abstract: The invention relates to secreted proteins from cardiac stem cells (cardiospheres and cardiosphere-derived cells) or myocytes for diagnostic and/or therapeutic use
    Type: Application
    Filed: December 19, 2013
    Publication date: September 18, 2014
    Applicant: The Johns Hopkins University
    Inventors: Eduardo Marban, Jennifer Van Eyk, Miroslava Stasna
  • Publication number: 20140186852
    Abstract: This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.
    Type: Application
    Filed: July 29, 2013
    Publication date: July 3, 2014
    Applicant: The Johns Hopkins University
    Inventors: Jennifer Van Eyk, Simon Sheng, Qin Fu
  • Publication number: 20140045713
    Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injuries. Brain injury can include overt or traumatic brain injury, as well as subclinical brain injury (SCI). In one embodiment, a method for diagnosing SCI in a patient comprises (a) collecting a sample from the patient; (b) measuring the levels of a panel of biomarkers in the sample collected from the patient, wherein the panel of biomarkers comprises ASTN1, BAI3, CNDP1, ERMIN, GFAP, GRM3, KLH32, MAGE2, NRG3, NRGN, OMG, SLC39A12, RTN1, and MT3; and (c) comparing the levels of the panel of biomarkers with predefined levels of the same panel of biomarkers that correlate to a patient having SCI and predefined levels of the same panel of biomarkers that correlate to a patient not having SCI, wherein a correlation to one of the predefined levels provides the diagnosis.
    Type: Application
    Filed: October 14, 2011
    Publication date: February 13, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Allan Dale Everett, James Francis Casella, Jennifer Van Eyk
  • Patent number: 8497078
    Abstract: This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: July 30, 2013
    Assignee: The Johns Hopkins University
    Inventors: Jennifer Van Eyk, Simon Sheng, Qin Fu
  • Publication number: 20120303083
    Abstract: This invention relates to novel phosphorylation sites in the desmin protein that are associated with the onset of heart failure. The phosphorylation sites, i.e., Ser-27 and Ser-31, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subjects having a higher than normal level of the biomarker, and (iii) monitoring therapy of a subject at risk for the development of heart failure. Also described are antibodies, reagents, and kits for carrying out a method of the present invention.
    Type: Application
    Filed: May 26, 2010
    Publication date: November 29, 2012
    Applicant: The Johns Hopkins University
    Inventors: Giulio Agnetti, Jennifer Van Eyk
  • Publication number: 20120009174
    Abstract: This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.
    Type: Application
    Filed: May 26, 2009
    Publication date: January 12, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jennifer Van Eyk, Simon Sheng, Qin Fu
  • Publication number: 20120004133
    Abstract: Methods for determining if a subject has or is susceptible to having an age-associated vascular disorder are disclosed. The method includes determining if the subject exhibits altered expression of a product of one or more of the genes listed in Table 1 relative to a control level of expression of the gene product. Altered expression of one or more of the genes listed in Table 1 indicates that the subject has or is susceptible to having an age-associated vascular disorder. In specific examples the gene product is a product of the MFG-E8 and an increase in expression indicates the subject has or is susceptible to having an age-associated vascular disorder.
    Type: Application
    Filed: February 19, 2010
    Publication date: January 5, 2012
    Inventors: Mingyi Wang, Zongming Fu, Edward G. Lakatta, Jennifer Van Eyk