Abstract: An electronic device may be provided with an antenna module having a substrate. An antenna may be disposed on the substrate. The antenna may have a directly fed patch and parasitic patches. The antenna may be fed by a feed via. The parasitic patches may include a first layer of parasitic patches separated by a gap overlapping the directly fed patch. The parasitic patches may include an additional parasitic patch formed in a second layer. The additional parasitic patch may overlap the gap. A floating ground via may couple a center of the additional parasitic patch and a center of the directly fed patch to a landing pad in a ground layer. The landing pad may short the via to the ground layer at the radiating frequency of the antenna. The landing pad may be electrically floating at DC frequencies.

Abstract: A method for reducing sequencing by synthesis cycle time using a microfluidic device is provided. The microfluidic device comprises a flow cell having an inlet port, an outlet port, and a flow channel extending between the inlet port and the outlet port, wherein the flow channel receives an analyte of interest and one or more reagents for analyzing and detecting molecules. To aid in the acceleration of the reactions, the microfluidic device comprises a mixing device to increase the rates of diffusion of the reagents from the fluid bulk to an active surface of the flow cell. The mixing device comprises at least one of an electrothermal mixing device, an active mechanical mixing device, and a vibrational mixing device.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: An object processing system is disclosed that includes a first support structure for supporting a plurality of containers that are positioned to receive a plurality of objects, a second support structure for receiving any of the plurality of containers when each of the plurality of containers is ready to be discharged from the first support structure, and an automated mobile transfer unit for selectively transferring a selected container from the first support structure to the second support structure, said automated mobile transfer unit including a mobile chassis unit for moving the at least one automated mobile transfer unit in a first direction among the first support structure and the second support structure, and a payload transfer system supported by the mobile chassis unit and adapted to transfer a selected container of the plurality of containers from the first support structure to the second support structure.

Abstract: An object processing system is disclosed that includes a distribution system for distributing a plurality of objects among a plurality of containers, an output conveyance system for receiving a plurality of completed containers, and a container discharge system for emptying any contents of a container of the plurality of completed containers into a destination location, the container discharge system including a discharge conveyor section in which the container is suspended and moved in a conveyor direction while permitting a bottom of the container to drop open to discharge any contents of the container into the destination location.

Abstract: Methods, computer systems, computer-storage media, and graphical user interfaces are provided for efficiently generating and using intent taxonomies. In embodiments, training data, including data requests for information, is obtained. Thereafter, a model prompt to be input into a large language model is generated. The model prompt includes an instruction to generate an intent taxonomy, an indication of the training data to use for generating the intent taxonomy, and a taxonomy attribute desired to be used as criteria to generate a quality intent taxonomy. An intent taxonomy that includes user intent classes is obtained as output from the large language model. The intent taxonomy is analyzed to determine whether the intent taxonomy is valid. When the intent taxonomy is determined as valid, the intent taxonomy is provided for use in identifying user intent, and when the intent taxonomy is determined as invalid, the intent taxonomy is refined.

Abstract: The present disclosure provides for compounds of the general Formula (I) wherein R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and Ring A have any of the values defined in the specification, and pharmaceutically acceptable salts thereof.

Abstract: In implementations of systems for estimating three-dimensional trajectories of physical objects, a computing device implements a three-dimensional trajectory system to receive radar data describing millimeter wavelength radio waves directed within a physical environment using beamforming and reflected from physical objects in the physical environment. The three-dimensional trajectory system generates a cloud of three-dimensional points based on the radar, each of the three-dimensional points corresponds to a reflected millimeter wavelength radio wave within a sliding temporal window. The three-dimensional points are grouped into at least one group based on Euclidean distances between the three-dimensional points within the cloud. The three-dimensional trajectory system generates an indication of a three-dimensional trajectory of a physical object corresponding to the at least one group using a Kalman filter to track a position and a velocity a centroid of the at least one group in three-dimensions.

Abstract: Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

Abstract: A method of treating tissue of a patient's body includes providing a power source coupled to at least one probe assembly. The probe assembly includes an elongate member with a distal region and a proximal region. The distal region has an electrically and thermally-conductive energy delivery device for delivering one of electrical and radiofrequency energy to the patient's body. The electrically and thermally-conductive energy delivery device has one or more internal lumens for circulating a cooling fluid therethrough and an electrically and thermally-conductive protrusion having a temperature sensing element. The temperature sensing element extends from a distal end of the energy delivery device. The method includes inserting the energy delivery device of the at least one probe assembly into the patient's body. Further, the method includes routing the energy delivery device of the at least one probe assembly to the tissue of the patient's body.

Abstract: A method for obtaining from genomic material genomic copy number information unaffected by amplification distortion, comprising obtaining segments of the genomic material, tagging the segments with substantially unique tags to generate tagged nucleic acid molecules, such that each tagged nucleic acid molecule comprises one segment of the genomic material and a tag, subjecting the tagged nucleic acid molecules to polymerase chain reaction (PCR) amplification, generating tag associated sequence reads by sequencing the product of the PCR reaction, assigning each tagged nucleic acid molecule to a location on a genome associated with the genomic material by mapping the subsequence of each tag associated sequence read corresponding to a segment of the genomic material to a location on the genome, and counting the number of tagged nucleic acid molecules assigned to the same location on the genome having a different tag, thereby obtaining genomic copy number information unaffected by amplification distortion.

Abstract: The technology disclosed herein enables configuration and sharing of a coverage map which displays asset data. In various implementations, an asset owner provides access to select portions of asset data, such as vehicle performance data, to an end-user. The asset owner configures a coverage map to display the selected data according to the type of asset data to be displayed, the scope of the data to be displayed, and other map attributes. Once configured, a URL is generated which the fleet operator provides to the end-user.

Abstract: A method of operating a mobile cleaning robot can include engaging a flooring surface of an environment with a cleaning pad of the mobile cleaning robot. At least one wheel of the mobile cleaning robot can be operated to move the mobile cleaning robot forward relative to the flooring surface a first time along a cleaning rank while the cleaning pad is engaged with the flooring surface. After moving forward, at least one wheel can be operated to move the mobile cleaning robot rearward relative to the flooring surface along the cleaning rank while the cleaning pad is engaged with the flooring surface. After moving rearward, at least one wheel can be operated to move the mobile cleaning robot forward a second time relative to the flooring surface along the cleaning rank while the cleaning pad is engaged with the flooring surface.

Abstract: One or more embodiments relate to a CEM having a hierarchical, interconnected, 3D network of thin, crumpled, graphene sheets, wherein the graphene sheets have irregularly shaped, micro-, macro- and meso-scale pore structures, where the CEM material has a BET SSA between approximately 1400 m2 g?1 and approximately 2200 m2 g?1, and where the CEM has a Raman ID/IG intensity ratio between approximately 0.05 to approximately 1.2, and a Raman I2D/IG intensity ratio between approximately 0.4 and approximately 0.8, and supercapacitors using the CEM as electrodes.

Abstract: One or more embodiments relate to a method for making carbon electrode material (CEM) having the steps: dispersing a carbon feedstock within a catalyst, thereby forming a mixture, wherein the catalyst is made up of particles; melting the carbon feedstock that is dispersed within the catalyst, thereby liquifying the carbon feedstock that coats catalyst particles and infiltrates spaces between the catalyst particles; carbonizing the melted carbon feedstock, thereby forming an interconnected 3D network of carbon nanosheets; converting the carbon nanosheets into graphene nanosheets; washing the graphene nanosheets, thereby forming the CEM; recovering and regenerating the catalyst. Further embodiments relate to repeating the method using recovered and regenerated catalyst.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

Abstract: An object processing system is disclosed that includes an infeed processing system including a source bin feed conveyor for providing source bins, a distribution system for receiving the source bins and for receiving a plurality of empty bins, and for providing objects from the source bins to a collection of processing locations, each processing location including an empty bin of the plurality of empty bins thereby providing the previously empty bins as processed bins when completed, and an outfeed processing system for moving the processed bins away from the collection of processing locations, wherein the empty bins and the processed bins are each positioned at some point in their respective output paths on a common out-feed conveyor.