Abstract: Quantum sensors provide excellent performance combining high sensitivity with spatial resolution. Unfortunately, they can only detect signal fields at frequencies in a few accessible ranges, typically low frequencies up to the experimentally achievable control field amplitudes and a narrow window around their resonance frequencies. Fortunately, arbitrary-frequency signals can be detected by using the sensor qubit as a quantum frequency mixer, enabling a variety of sensing applications. The technique leverages nonlinear effects in periodically driven (Floquet) quantum systems to achieve quantum frequency mixing of the signal and an applied AC bias field. The frequency-mixed field can be detected using Rabi and CPMG sensing techniques with the bias field. Frequency mixing can distinguish vectorial components of an oscillating signal field, thus enabling arbitrary-frequency vector magnetometry.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: Various technologies relating to wireless sensor networks (WSNs) are disclosed, including, but not limited to, device onboarding and authentication, network association and synchronization, data logging and reporting, asset tracking, and automated flight state detection.

Abstract: Provided herein are exemplary embodiments including a computer-implemented method of using artificial intelligence for automatically collecting and enriching network data for a smart campaign with autopilot features. The method includes, collecting a set of network data relevant to a smart campaign with autopilot features, applying one or more transformations to the collected set of data to create a modified set of data, generating from the modified set of data, enriched network data for a smart campaign with autopilot features, the enriched network data having content, context and event data, and using the enriched data to deploy a personalized campaign by identifying an audience, time, channel, content and goal of the communication.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

Abstract: Disclosed herein include antibodies or fragments thereof having specificity to a sarbecovirus spike protein. Also provided are compositions, methods, and kits for using said antibodies or fragments thereof for preventing or treating, for example a coronavirus infection.

Abstract: An electronic device may be provided with a flexible printed circuit and a rigid printed circuit mounted to the flexible printed circuit using a board-to-board (B2B) connector. The flexible printed circuit may include signal conductors coupled to one or more antennas on the rigid printed circuit through the B2B connector. A given one of the signal conductors may include a phase shifter segment on the flexible printed circuit and/or a thick impedance matching segment on the rigid printed circuit that help to form a smooth impedance transition from the flexible printed circuit to the rigid printed circuit and the antenna(s). The B2B connector may include signal contacts interleaved with a ground contacts. The B2B connector may include ground bars laterally surrounding the signal and ground contacts to maximize the strength of mechanical coupling between the flexible printed circuit and the rigid printed circuit.

Abstract: A method of recommending an unplayed game application to a user includes obtaining a game history associated with a user profile, wherein the game history includes at least one game record of a game application the user profile has been used to play, and evaluating the game history to obtain a plurality of game events associated with a game application of the game history. The method further includes accessing a table of tags associated with the plurality of game events associated with the game application, aggregating a plurality of tags in a tag list in the user profile based at least partially on the table of tags and the plurality of game events, and presenting to the user a recommendation of an unplayed game application based at least partially on the plurality of tags.

Abstract: In some aspects, the described systems and methods provide for validating performance of a model trained on a plurality of annotated pathology images. A pathology image is accessed. Frames are generated using the pathology image. Each frame in the set includes a distinct portion of the pathology image. Reference annotations are received from one or more users. The reference annotations describe at least one of a plurality of tissue or cellular characteristic categories for one or more frames in the set. Each frame in the set is processed using the trained model to generate model predictions. The model predictions describe at least one of the tissue or cellular characteristic categories for the processed frame. Performance of the trained model is validated based on determining a degree of association between the reference annotations and the model predictions for each frame and/or across all frames in the set of frames.

Abstract: Disclosed herein are compositions and methods for increasing the immunocompatibility of donor cells (e.g., HSCs or T-cells) for transplantation to a recipient subject, as well as database schemes for use in the methods. The methods and compositions described herein result in the allele-specific modification of one or more immunogenicity genes (e.g., an HLA gene) of a cell, resulting in cells that are suitable for transplantation into a recipient subject.

Abstract: Methods and systems are provided for communication of one or more campaigns via personalized electronic messaging. An example method includes automatically creating an electronic communication personalized for each of a plurality of individual customers of a client. The automatically creating may include dynamic configuring the electronic communication for each individual customer into a single campaign for the client to optimize both relevancy for each of a plurality of individual customers and one or more desired business outcomes for the client. The dynamic configuring can include decision making using at least a business context. Performance goals of a business can comprise the business context. The decision-making can further use a user context and/or an external context. The electronic communication can be dynamically configured to include personalized recommendations and may further include personalized content and/or a personalized offer.

Abstract: A method for real-time invoice updating and account-to-account payment includes: receiving invoice data based on presentation of an invoice by a distributor to a recipient at a delivery location, modification of the invoice by the recipient, and acceptance of the invoice by the recipient; generating a request for payment (RFP) message based on the invoice data; transmitting the RFP message to a financial institution associated with the recipient via a financial institution of the distributor; receiving, from the financial institution associated with the distributor, a payment confirmation for the invoice based on a real-time payment from the financial institution associated with the recipient; generating reconciliation data based on the payment confirmation and the invoice data; and transmitting the reconciliation data to a computing device of the distributor and a computing device of the recipient.

Abstract: A method for real-time invoice updating and account-to-account payment includes: receiving invoice data based on presentation of an invoice by a distributor to a recipient at a delivery location, modification of the invoice by the recipient, and acceptance of the invoice by the recipient; generating a request for payment (RFP) message based on the invoice data; transmitting the RFP message to a financial institution associated with the recipient via a financial institution of the distributor; receiving, from the financial institution associated with the distributor, a payment confirmation for the invoice based on a real-time payment from the financial institution associated with the recipient; generating reconciliation data based on the payment confirmation and the invoice data; and transmitting the reconciliation data to a computing device of the distributor and a computing device of the recipient.

Abstract: The disclosure relates to methods for producing an adeno-associated virus (AAV) in an E1 complementary producer cell.

Abstract: A method for reducing sequencing by synthesis cycle time using a microfluidic device is provided. The microfluidic device comprises a flow cell having an inlet port, an outlet port, and a flow channel extending between the inlet port and the outlet port, wherein the flow channel receives an analyte of interest and one or more reagents for analyzing and detecting molecules. To aid in the acceleration of the reactions, the microfluidic device comprises a mixing device to increase the rates of diffusion of the reagents from the fluid bulk to an active surface of the flow cell. The mixing device comprises at least one of an electrothermal mixing device, an active mechanical mixing device, and a vibrational mixing device.

Abstract: Methods and systems are provided for communication of one or more campaigns via personalized electronic messaging. An example method includes automatically creating an electronic communication personalized for each of a plurality of individual customers of a client. The automatically creating may include dynamic configuring the electronic communication for each individual customer into a single campaign for the client to optimize both relevancy for each of a plurality of individual customers and one or more desired business outcomes for the client. The dynamic configuring can include decision making using at least a business context. Performance goals of a business can comprise the business context. The decision-making can further use a user context and/or an external context. The electronic communication can be dynamically configured to include personalized recommendations and may further include personalized content and/or a personalized offer.

Abstract: A method for real-time invoice updating and account-to-account payment includes: receiving invoice data based on presentation of an invoice by a distributor to a recipient at a delivery location, modification of the invoice by the recipient, and acceptance of the invoice by the recipient; generating a request for payment (RFP) message based on the invoice data; transmitting the RFP message to a financial institution associated with the recipient via a financial institution of the distributor; receiving, from the financial institution associated with the distributor, a payment confirmation for the invoice based on a real-time payment from the financial institution associated with the recipient; generating reconciliation data based on the payment confirmation and the invoice data; and transmitting the reconciliation data to a computing device of the distributor and a computing device of the recipient.