Abstract: Antibodies that bind to programmed cell death protein 1 (PD-1), compositions comprising such antibodies, and methods of making and using such antibodies are disclosed.

Abstract: Antibodies that bind to programmed cell death protein 1 (PD-1), compositions comprising such antibodies, and methods of making and using such antibodies are disclosed.

Abstract: The invention provides monoclonal antibodies and antigen-binding fragments thereof specific for TNFR2, and methods of using the same to treat cancer or autoimmune disorder, including combination therapy with antagonists of the PD-1/PD-L1 immune checkpoint.

Abstract: Antibodies that bind to programmed cell death protein 1 (PD-1), compositions comprising such antibodies, and methods of making and using such antibodies are disclosed.

Abstract: The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer or inflammatory conditions mediated by autoreactive B cells in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize at least one tumor antigen or B-lineage cell antigen and NKp30 and/or another activating NK receptor. In some aspects, multispecific antigen-binding constructs are provided that recognize at least two tumor antigens or two antigens expressed by B-lineage cells, NKp30, and another activating NK receptor. The multispecific antigen-binding constructs and methods disclosed herein can be used for the treatment of cancer, even a cancer characterized by a CD16 deficient microenvironment and/or characterized by target cells (e.g., cancer cells) having a low level of expression of the tumor antigen.

Abstract: The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer or inflammatory conditions mediated by autoreactive B cells in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize at least one tumor antigen or B-lineage cell antigen and NKp30 and/or another activating NK receptor. In some aspects, multispecific antigen-binding constructs are provided that recognize at least two tumor antigens or two antigens expressed by B-lineage cells, NKp30, and another activating NK receptor. The multispecific antigen-binding constructs and methods disclosed herein can be used for the treatment of cancer, even a cancer characterized by a CD16 deficient microenvironment and/or characterized by target cells (e.g., cancer cells) having a low level of expression of the tumor antigen.

Abstract: Antibodies that bind to programmed cell death protein 1 (PD-1), compositions comprising such antibodies, and methods of making and using such antibodies are disclosed.

Abstract: A device may include a flexible substrate. The device may further include a flexible integrated circuit within the flexible substrate, the integrated circuit having at least one input electrode positioned on a surface of the flexible substrate. The device may also include an aerosol jet printed conductive ink layer disposed on the surface of the flexible substrate, the aerosol-jet printed conductive ink layer having a pattern that includes a first set of fingers interdigitated with a second set of fingers, the aerosol jet printed conductive ink layer in contact with the at least one input electrode.

Abstract: Antibodies that bind to programmed cell death protein 1 (PD-1), compositions comprising such antibodies, and methods of making and using such antibodies are disclosed.

Abstract: A device may include a flexible substrate. The device may further include a flexible integrated circuit within the flexible substrate, the integrated circuit having at least one input electrode positioned on a surface of the flexible substrate. The device may also include an aerosol jet printed conductive ink layer disposed on the surface of the flexible substrate, the aerosol-jet printed conductive ink layer having a pattern that includes a first set of fingers interdigitated with a second set of fingers, the aerosol jet printed conductive ink layer in contact with the at least one input electrode.

Abstract: This invention is a method and system for reserving and controlling access to products and services at a remote location via a communications network. In one or more embodiment, a user uses a client computer to select desired products and services. The system returns a price offer for the packaged products and services. Upon acceptance of the price offer, the selection of products and services is forwarded to an operations center for the building of an event regarding the redemption of the products and services. The system allocates a time frame for the redemption of each of the products and services as well as determining the order of redemption, based on polling a plurality of users desiring the same products and services in an event. The information generated by the operation center is then forwarded to a location for the redemption of the products and services.

Abstract: Antibodies that bind to programmed cell death protein 1 (PD-1), compositions comprising such antibodies, and methods of making and using such antibodies are disclosed.

Abstract: Antibodies that bind to programmed cell death protein 1 (PD-1), compositions comprising such antibodies, and methods of making and using such antibodies are disclosed.

Abstract: This invention is a method and system for reserving and controlling access to products and services at a remote location via a communications network. In one or more embodiment, a user uses a client computer to select desired products and services. The system returns a price offer for the packaged products and services. Upon acceptance of the price offer, the selection of products and services is forwarded to an operations center for the building of an event regarding the redemption of the products and services. The system allocates a time frame for the redemption of each of the products and services as well as determining the order of redemption, based on polling a plurality of users desiring the same products and services in an event. The information generated by the operation center is then forwarded to a location for the redemption of the products and services.

Abstract: This invention is a method and system for reserving and controlling access to products and services at a remote location via a communications network. In one or more embodiment, a user uses a client computer to select desired products and services. The system returns a price offer for the packaged products and services. Upon acceptance of the price offer, the selection of products and services is forwarded to an operations center for the building of an event regarding the redemption of the products and services. The system allocates a time frame for the redemption of each of the products and services as well as determining the order of redemption, based on polling a plurality of users desiring the same products and services in an event. The information generated by the operation center is then forwarded to a location for the redemption of the products and services.